Zobrazeno 1 - 10 of 19 pro vyhledávání: '"T N Wells"'
1
IL-8-induced signal transduction in T lymphocytes involves receptor-mediated activation of phospholipases C and D
Autor: K B Bacon, L Flores-Romo, P F Life, D D Taub, B A Premack, S J Arkinstall, T N Wells, T J Schall, C A Power
Publikováno v: The Journal of Immunology. 154:3654-3666
We have characterized the IL-8-induced signal transduction processes in T lymphocytes. A basal level of IL-8 receptor expression was shown on mixed PBL, as identified by using phycoerythrin (PE)-coupled IL-8, and this expression was increased followi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::732bd9b2635fdfa055d61fea16eae409
https://doi.org/10.4049/jimmunol.154.8.3654
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2
Chemokine receptors--the next therapeutic target for HIV?
Autor: M, Schwarz, T N, Wells, A E, Proudfoot
Publikováno v: Receptorschannels. 7(6)
To date, the available therapies for the treatment of HIV infection are targeted against proteins encoded by the virus itself. Thus, combination drug therapies for HIV with reverse transciptase and protease inhibitors have resulted in spectacular red
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b71501d69deab0f2e8f724f0ca6feb11
https://pubmed.ncbi.nlm.nih.gov/11918344
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3
Bilinexin, a snake C-type lectin from Agkistrodon bilineatus venom agglutinates platelets via GPIb and alpha2beta1
Autor: X Y, Du, A, Navdaev, J M, Clemetson, E, Magnenat, T N, Wells, K J, Clemetson
Publikováno v: Thrombosis and haemostasis. 86(5)
A new snake protein, named bilinexin, has been purified from Agkistrodon bilineatus venom by ion-exchange chromatography and gel filtration chromatography. Under non-reducing conditions it has a mass of 110 kDa protein on SDS-PAGE. On reduction, it c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a5a37b582d248db80054047a578c7c
https://pubmed.ncbi.nlm.nih.gov/11816718
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4
The strategy of blocking the chemokine system to combat disease
Autor: A E, Proudfoot, C A, Power, T N, Wells
Publikováno v: Immunological reviews. 177
One of the key characteristics of inflammation is the recruitment of leukocytes to the site of inflammation. Most anti-inflammatory strategies act intracellularly on the target cells, but after the cells have migrated to the site. We therefore propos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c3ffbd7239bccd2012958c9bdc4e411
https://pubmed.ncbi.nlm.nih.gov/11138781
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5
Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets
Autor: K J, Clemetson, J M, Clemetson, A E, Proudfoot, C A, Power, M, Baggiolini, T N, Wells
Publikováno v: Blood. 96(13)
Platelets are known to contain platelet factor 4 and beta-thromboglobulin, alpha-chemokines containing the CXC motif, but recent studies extended the range to the beta-family characterized by the CC motif, including RANTES and Gro-alpha. There is als
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e653b8d59817fc3c64a45ac3dbe11e1
https://pubmed.ncbi.nlm.nih.gov/11110672
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7
[Reduction of acute kidney transplantation rejection by the chemokine receptor antagonist Met-RANTES]
Autor: H J, Gröne, C, Weber, K S, Weber, E F, Gröne, C M, Klier, T N, Wells, A E, Proudfoot, D, Schlöndorff, P J, Nelson
Publikováno v: Verhandlungen der Deutschen Gesellschaft fur Pathologie. 83
Chemokines contribute to the mononuclear cell infiltrate in vessels and interstitium which is characteristic of renal transplant rejection. By employing the chemokine receptor blocker Met-RANTES it was shown that recruitment of inflammatory cells int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::72b66d76e05a5ae2a7eaff1301da9834
https://pubmed.ncbi.nlm.nih.gov/10714211
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9
Chemokine receptors--future therapeutic targets for HIV?
Autor: A E, Proudfoot, T N, Wells, P R, Clapham
Publikováno v: Biochemical pharmacology. 57(5)
To date, triple drug therapies for HIV have resulted in spectacular reductions in the number of virus particles and often remarkable recovery from disease in infected people. There is still, however, a great need for improved therapies. A battery of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::618697107073cdf941e929897ab9dadd
https://pubmed.ncbi.nlm.nih.gov/9952309
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10
Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils
Autor: R, Bonecchi, N, Polentarutti, W, Luini, A, Borsatti, S, Bernasconi, M, Locati, C, Power, A, Proudfoot, T N, Wells, C, Mackay, A, Mantovani, S, Sozzani
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(1)
Human neutrophils (polymorphonuclear leukocytes; PMN) respond to some CXC chemokines but do not migrate to CC chemokines. Recent work has shown that chemokine receptors can be modulated by inflammatory cytokines. In this study, the effect of IFN-gamm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9e91b93e1ba3037981538f76617d568
https://pubmed.ncbi.nlm.nih.gov/9886422
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