Výsledky vyhledávání - "T N, Tulenko"

Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions

Autor: Bonita Falkner, H Kushner, A.E. Sumner, T N Tulenko, Katherine Sherif, J B Marsh

Publikováno v: Diabetes Care. 22:71-77

OBJECTIVE: The purpose of this study was to determine if there are sex differences in African-Americans regarding the effect of obesity on sensitivity to insulin as a glucoregulatory and antilipolytic hormone. RESEARCH DESIGN AND METHODS: Data from s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36474401c2d24d88c583aaba7635f8bc
https://doi.org/10.2337/diacare.22.1.71

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Altered contractile and ion channel function in rabbit portal vein with dietary atherosclerosis

Autor: T. N. Tulenko, Robert H. Cox

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 268:H2522-H2530

This study was performed to determine the effects of dietary atherosclerosis on the pharmacology and ion channel properties of rabbit portal vein (PV). New Zealand White rabbits were fed normal rabbit chow +/- 2% cholesterol for 10 wk. Contractions t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98805681135cc4038a03f5742736e277
https://doi.org/10.1152/ajpheart.1995.268.6.h2522

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Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells

Autor: Wilson S. Colucci, T N Tulenko, Nicholas J. Izzo

Publikováno v: Journal of Biological Chemistry. 269:1705-1710

The mechanism by which norepinephrine (NE) down-regulates alpha 1B-adrenergic receptor (alpha-AR) mRNA was studied in rabbit aortic smooth muscle cells. NE, phorbol esters, and bradykinin each decreased alpha-AR mRNA levels by 70-80%. The protein kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27562c54298a121183e47e029c2e2fb6
https://doi.org/10.1016/s0021-9258(17)42085-0

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Acute exposure to cholesterol increases arterial nitroprusside- and endothelium-mediated relaxation

Autor: T. N. Tulenko, R. A. Bialecki

Publikováno v: American Journal of Physiology-Cell Physiology. 264:C32-C39

The effect of cholesterol enrichment on arterial relaxation was studied by evaluating sodium nitroprusside (SNP)- and endothelium-mediated relaxation of isolated rabbit carotid artery. Arterial segments were perfused in vitro (4 h) with cholesterol-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382a645c175d28fe4776e9d201717c49
https://doi.org/10.1152/ajpcell.1993.264.1.c32

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Atheroprotection with amlodipine: cells to lesions and the PREVENT trial. Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial

Autor: T N, Tulenko, J, Brown, L, Laury-Kleintop, M, Khan, M F, Walter, R P, Mason

Publikováno v: Journal of cardiovascular pharmacology. 33

Oxidized lipid and calcium regulatory abnormalities appear to play important roles in early atherogenesis secondary to cholesterol enrichment of the cell membrane in endothelial and arterial smooth muscle cells (SMCs). However, the link between the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0133767a5b960c2b4d0729779b12a25f
https://pubmed.ncbi.nlm.nih.gov/10071259

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Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis

Autor: T N, Tulenko, M, Chen, P E, Mason, R P, Mason

Publikováno v: Journal of lipid research. 39(5)

Small angle X-ray diffraction was used to examine arterial smooth muscle cell (SMC) plasma membranes isolated from control and cholesterol-fed (2%) atherosclerotic rabbits. A microsomal membrane enriched with plasma membrane obtained from animals fed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd1990e48c04c806af0af5d3626d6e19
https://pubmed.ncbi.nlm.nih.gov/9610760

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The molecular basis for lacidipine's unique pharmacokinetics: optimal hydrophobicity results in membrane interactions that may facilitate the treatment of atherosclerosis

Autor: L G, Herbette, P E, Mason, G, Gaviraghi, T N, Tulenko, R P, Mason

Publikováno v: Journal of cardiovascular pharmacology. 23

Membrane-active drugs can be characterized by direct measurements of their membrane partition coefficients, washout rates from membranes, and washin rates into membranes. There appears to be a correlation between the duration of action of such membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80ca29fd59c4b29e6889913a0ff0f2f1
https://pubmed.ncbi.nlm.nih.gov/7609501

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Case conference. Case 2--1993. Cardiopulmonary bypass in a patient with connective tissue disease (Ehlers-Danlos syndrome) and multiple, small arteriovenous fistulae

Autor: M E, Comunale, M, Moens, P, Furlong, E, Ehrl, J, Pawlowski, T N, Tulenko, R F, Tuma

Publikováno v: Journal of cardiothoracic and vascular anesthesia. 7(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9f7656f775a725d2dde2b2df2900518
https://pubmed.ncbi.nlm.nih.gov/8518385

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Excess membrane cholesterol alters calcium movements, cytosolic calcium levels, and membrane fluidity in arterial smooth muscle cells

Autor: M S Medow, T N Tulenko, M M Gleason

Publikováno v: Circulation research. 69(1)

The relations between membrane cholesterol content, basal (unstimulated) transmembrane 45Ca2+ movements, cytosolic calcium levels, and membrane fluidity were investigated in cultured rabbit aortic smooth muscle cells (SMCs) and isolated SMC plasma me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b7091236cae3f9b8e7db4bdb30b69f
https://pubmed.ncbi.nlm.nih.gov/2054935

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