Zobrazeno 1 - 10
of 16
pro vyhledávání: '"T N, Akopian"'
Publikováno v:
The Journal of biological chemistry. 274(6)
Knowledge about the sizes of peptides generated by proteasomes during protein degradation is essential to fully understand their degradative mechanisms and the subsequent steps in protein turnover and generation of major histocompatibility complex cl
Publikováno v:
Biological chemistry. 378(3-4)
Recent studies of the 20S proteasome from Thermoplasma acidophilum have uncovered some fundamental new properties of its catalytic mechanism. Unlike conventional proteases, 20S and 26S proteasomes degrade protein substrates in a highly processive fas
Publikováno v:
Molecular biology reports. 24(1-2)
Publikováno v:
Voprosy meditsinskoi khimii. 39(6)
A procedure, developed for quantitative estimation of peptides in protein free blood serum, involved registration of products formed after reaction of peptide amino groups with o-phthalic aldehyde. The procedure developed was 50-100-fold more sensiti
Publikováno v:
Voprosy meditsinskoi khimii. 39(1)
Proteolytic activity and activity of endogenous inhibitors of endopeptidases (using chymotrypsin and papain) were studied in the myocardium of rats with experimental ischemia during an acute phase (60 min) and within 5 days after ligation of the left
Publikováno v:
Bioorganicheskaia khimiia. 17(12)
Proteolytic conversions of some neuropeptides possessing neurotransmitter and neuromodulator properties were studied on the synaptosomal plasma membrane level. The main goal was to describe the peptide bonds being primarily hydrolysed by membrane pep
Publikováno v:
Voprosy meditsinskoi khimii. 36(3)
Cardioactive drugs--beta-adrenoblocking agents (propranolol, trasicor and cordanum) and Ca2(+)-antagonists (nifedipine and phenoptine)--exhibited both activating and inhibitory effects on proteolytic activity in rat heart tissue extract. The beta-adr
[Glutathione disulfide inhibits degradation of substance P induced by synaptosomal plasma membranes]
Publikováno v:
Biokhimiia (Moscow, Russia). 54(12)
The effects of phosphorylation, ribosylation of proteins and formation of protein-mixed disulfides on substance P degradation under the action of synaptosomal plasma membranes were studied. It was found that only the formation of mixed disulfides bet
Publikováno v:
Ukrainskii biokhimicheskii zhurnal (1. 53(6)
Six peaks of the endopeptidase activity at pH 3.2 were obtained after isoelectric focusing of soluble fractions of cortex and hypothalamus of the human brain. The molecular weight of these endopeptidases are approximately 50000. All obtained endopept
Publikováno v:
Ukrainskii biokhimicheskii zhurnal (1. 60(2)
Protein substrates for proteinases with double fluorescent fluorophors are synthesized. Pyridoxal-5'-phosphate, dansyl chloride and fluorescein isothiocyanate were used as fluorescent sounds for modification of globin. Phosphoyridoxyl fluorophor was