Výsledky vyhledávání

Zidovudine, didanosine, and zalcitabine in the treatment of HIV infection: meta-analyses of the randomised e vidence

Autor: A Gringeri, P Hartigan, R D'Aquila, J Yeo, L Dee, A Maeland, F Rousseau, J Darbyshire, M Flepp, T Merigan, H Chang, J Chodakewitz, C Farthing, K Stanley, G Van Weverling, L Mathiesen, R DeMasi, P Slade, H Melander, C Pettinelli, A Poppa, C Carbon, D Smith, M Seligmann, G Stingl, C Tierney, M Hughes, I Chalmers, M Foulkes, D Katzenstein, B Gazzard, L Struthers, Soriano, K Henry, J Veenstra, I Weller, S Danner, M Sande, L Deyton, E Sandstrom, M Fischl, A Phillips, D Richman, C Katlama, M Gartland, J Neaton, E King, A Collier, P Gotzsche, P Stoffels, G Rutherford, R Van der Broeck, D Allan, R Peto, J Rooney, J Ioannidis, W Duncan, F Antunes, S Schnittman, N Clendenin, J Lange, D Dixon, SK de Loes, A Babiker, E Cooper, D Hall, J Killen, P Volberding, A Hill, H McDade, A Meibohn, G Savidge, L Saravolatz, J Bruun, W Cameron, L Perrin, A Pinching, N Clumeck, M Simberkoff, P Mannucci, J Gatell, T Peto, M Heath-Chiozzi, M Salgo, G Skowron, R Van Leeuven, L Power, S Vella, J Phair, P Reiss, J Kahn, DeGruttola, D Winslow, M Myers, R Schooley, B Hirschel, S Hammer, R Leavitt, S Walker, G Collins, R Collins, J Leonard, RP Smith, D Abrams, J Mulder, J Hamilton, M Thompson, M Nessling, S Kravcik, Hiv Trialists' Collaborative Grp, D Cooper, A Breckenridge, F Goebel, J Dormont, J Weber, P Yeni, J Feinberg

Publikováno v: The Lancet. 353:2014-2025

Summary Background To assess the effects of zidovudine, didanosine, and zalcitabine on HIV disease progression and survival, we undertook meta-analyses of individual patient data and tabular data from all randomised trials that compared these agents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9973fab0ba3628e3974bd59a2556e5f1
https://doi.org/10.1016/s0140-6736(98)12263-8

Zobrazit plný text záznamu

Individualization of therapy using viral markers

Autor: T, Merigan

Publikováno v: Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 10

Early intervention with a combination of drugs is generally accepted as the way forward in the management of HIV infection. In general, combination therapy should include agents that demonstrate additive or synergistic activity, do not have similar s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ccba5d24f754ec93ad5ef56d25d7f69
https://pubmed.ncbi.nlm.nih.gov/8595507

Zobrazit plný text záznamu

Zidovudine and dideoxycytidine differ in their effects on human immunodeficiency virus-induced pathologic activation of the immune system. AIDS Clinical Trial Research Group 047

Autor: M, Liu, J L, Fahey, N, Aziz, W G, Cumberland, G, Skowron, T, Merigan

Publikováno v: The Journal of infectious diseases. 170(5)

When zidovudine and dideoxycytidine (ddC) were given on schedules of 1 week on drug and 1 week off, results differed substantially in effects on HIV (human immunodeficiency virus type 1)-induced immune activation. Zidovudine (200 mg every 4 h) caused

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9185adc03711bd988735ff19adaae483
https://pubmed.ncbi.nlm.nih.gov/7963709

Zobrazit plný text záznamu

Pharmacokinetics of zidovudine alone and in combination with oxazepam in the HIV infected patient

Autor: L, Mole, D, Israelski, J, Bubp, P, O'Hanley, T, Merigan, T, Blaschke

Publikováno v: Journal of acquired immune deficiency syndromes. 6(1)

This three-phase study was designed to determine if a pharmacokinetic drug-drug interaction exists between zidovudine and oxazepam. Six individuals infected with human immunodeficiency virus (HIV) and receiving zidovudine at 500 mg daily, with normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e2fc693b22d35dbcfa9a8dda84b04ee8
https://pubmed.ncbi.nlm.nih.gov/8417175

Zobrazit plný text záznamu

Clinical trials of combination therapies for HIV infection. Discussion

Autor: J, McGowan, T, Merigan, S, Sherwin

Publikováno v: Journal of acquired immune deficiency syndromes. 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1815129e5ed546409b63bebe983a0969
https://pubmed.ncbi.nlm.nih.gov/2172505

Zobrazit plný text záznamu

Phase I evaluation of a synthetic mutant of beta-interferon

Autor: M, Hawkins, S, Horning, M, Konrad, S, Anderson, K, Sielaff, S, Rosno, J, Schiesel, T, Davis, D, DeMets, T, Merigan

Publikováno v: Cancer research. 45(11 Pt 2)

A synthetic mutant of beta-interferon, produced by recombinant DNA technology, was prepared with serine substituted for the naturally occurring cysteine at amino acid 17. This molecule, after purification to homogeneity, was evaluated in 23 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec715ef56866a36a9b8e754f83f85ca2
https://pubmed.ncbi.nlm.nih.gov/4053062

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání