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pro vyhledávání: '"T Mark Treherne"'
Autor:
Eugene O'Hare, David Spanswick, Kelly Norwood, David I.C. Scopes, Eun-Mee Kim, T Mark Treherne
Publikováno v:
Behavioural Brain Research. 210:32-37
Clinically accessible compounds that arrest or reverse the effects of amyloid-beta (A beta) on progressively developing behavioural symptomatology and neuropathology in Alzheimer's disease (AD) have yet to become available. However, a viable strategy
Autor:
Bridgeen McMahon, Philip Palmer, Andrew D. Whyment, Edmund Nerou, T Mark Treherne, Ross Jeggo, David I.C. Scopes, Hozefa Amijee, Martyn Jones, Eugene O'Hare, Eun-Mee Kim, David Spanswick
Publikováno v:
O'Hare, E, Scopes, D I C, Kim, E-M, Palmer, P, Jones, M, Whyment, A D, Spanswick, D, Amijee, H, Nerou, E, McMahon, B, Treherne, J M & Jeggo, R 2013, ' Orally bioavailable small molecule drug protects memory in Alzheimer's disease models ', Neurobiology of Aging, vol. 34, no. 4, pp. 1116-1125 . https://doi.org/10.1016/j.neurobiolaging.2012.10.016
Oligomers of beta-amyloid (Aß) are implicated in the early memory impairment seen in Alzheimer's disease before to the onset of discernable neurodegeneration. Here, the capacity of a novel orally bioavailable, central nervous system-penetrating smal