Zobrazeno 1 - 10
of 846
pro vyhledávání: '"T MCMANUS"'
Autor:
Michael J. Podolsky, Benjamin Kheyfets, Monika Pandey, Afaq H. Beigh, Christopher D. Yang, Carlos O. Lizama, Ritwik Datta, Liangguang L. Lin, Zhihong Wang, Paul J. Wolters, Michael T. McManus, Ling Qi, Kamran Atabai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Accumulating evidence has implicated impaired extracellular matrix (ECM) clearance as a key factor in fibrotic disease. Despite decades of research elucidating the effectors of ECM clearance, relatively little is understood regarding the ups
Externí odkaz:
https://doaj.org/article/f4c1e0221b354d99b77f1b6eea76ff85
Autor:
Hannah N. Gruner, Yaohuan Zhang, Kaavian Shariati, Nicholas Yiv, Zicheng Hu, Yuhao Wang, J. Fielding Hejtmancik, Michael T. McManus, Kevin Tharp, Gregory Ku
Publikováno v:
PeerJ, Vol 11, p e15077 (2023)
Understanding the interactions between SARS-CoV-2 and host cell machinery may reveal new targets to treat COVID-19. We focused on an interaction between the SARS-CoV-2 ORF3A accessory protein and the CLIC-like chloride channel-1 (CLCC1). We found tha
Externí odkaz:
https://doaj.org/article/590d8f46a4d94c51be4e8a3c2851636b
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010296 (2022)
After endocytosis, transmembrane cargo is differentially sorted into degradative or recycling pathways. This process is facilitated by recruitment into physically distinct degradative or recycling microdomains on the limiting membrane of individual e
Externí odkaz:
https://doaj.org/article/f8ce1d14bc934d50bc5b1b78d31f48be
Autor:
Ihsan Ullah, Helal A. Ansari, Isabelle M. Verry, Syed Wajid Hussain, Nick W. Ellison, Michael T. McManus, Warren M. Williams
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
White clover (Trifolium repens) is an allotetraploid pasture legume widely used in moist temperate climates, but its vulnerability to drought, grazing pressure and pests has restricted its wider use. A related species, Caucasian clover (Trifolium amb
Externí odkaz:
https://doaj.org/article/746cf3978a78493e8caa29ef039c9e10
Autor:
Michael Boettcher, Sergio Covarrubias, Anne Biton, James Blau, Haopeng Wang, Noah Zaitlen, Michael T. McManus
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background While pooled loss- and gain-of-function CRISPR screening approaches have become increasingly popular to systematically investigate mammalian gene function, the large majority of them have thus far not investigated the influence of
Externí odkaz:
https://doaj.org/article/36504d473df9495196bf6eb1d48e243e
Autor:
Eric W Martin, Alessandra Rodriguez y Baena, Roman E Reggiardo, Atesh K Worthington, Connor S Mattingly, Donna M Poscablo, Jana Krietsch, Michael T McManus, Susan Carpenter, Daniel H Kim, E Camilla Forsberg
Publikováno v:
Stem Cells. 41:520-539
Epigenetic mechanisms regulate the multilineage differentiation capacity of hematopoietic stem cells (HSCs) into a variety of blood and immune cells. Mapping the chromatin dynamics of functionally defined cell populations will shed mechanistic insigh
Autor:
Marcus J. Hines, Maryaline Coffre, Tenny Mudianto, Marisella Panduro, Eric J. Wigton, Cosmin Tegla, Victoria Osorio-Vasquez, Robin Kageyama, David Benhamou, Oriana Perez, Sofia Bajwa, Michael T. McManus, K. Mark Ansel, Doron Melamed, Sergei B. Koralov
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108436- (2020)
Summary: The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and te
Externí odkaz:
https://doaj.org/article/a347eca3ff184d66badee443d3b201b8
Autor:
Laura Bouchareychas, Phat Duong, Sergio Covarrubias, Eric Alsop, Tuan Anh Phu, Allen Chung, Michael Gomes, David Wong, Bessie Meechoovet, Allyson Capili, Ryo Yamamoto, Hiromitsu Nakauchi, Michael T. McManus, Susan Carpenter, Kendall Van Keuren-Jensen, Robert L. Raffai
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107881- (2020)
Summary: Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes produced by naive bone marrow-derived macrophages (BMDM-exo) contain anti-infla
Externí odkaz:
https://doaj.org/article/8eec14d6e9314bcca6dc8d52b7f5c412
Autor:
Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn T. Kissick, William H. Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James L. Ross, Se Jin Im, Junghwa Lee, Jian-Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jorg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed
Publikováno v:
Nature. 610:173-181
Autor:
Daphne J. Osborne, Michael T. McManus
Meristematic cells in plants become the many different types of cells found in a mature plant. This is achieved by a selective response to chemical signals both from neighbouring cells and distant tissues. It is these responses that shape the plant,