Andrographis paniculata improves glucose regulation by enhancing insulin sensitivity and upregulating GLUT 4 expression in Wistar rats

Autor: W. A. Saka, O. S. Oyekunle, T. M. Akhigbe, O. O. Oladipo, M. B. Ajayi, A. T. Adekola, A. I. Omole, R. E. Akhigbe

Publikováno v: Frontiers in Nutrition, Vol 11 (2024)

ContextAlthough the hypoglycaemic effect of Andrographis paniculata (Burm.f.) Nees [Acanthaceae] has been documented, reports on its effect in an apparently healthy state are limited.ObjectiveThis study investigated whether or not A. paniculata exert

Externí odkaz: https://doaj.org/article/b6ab32cba90b45ab9df5139331279ec2

Zinc improves sexual and erectile function in HAART-treated rats via the upregulation of erectogenic enzymes and maintenance of redox balance

Autor: R. E. Akhigbe, M. A. Hamed, A. F. Odetayo, T. M. Akhigbe, P. A. Oyedokun

Publikováno v: The Aging Male, Vol 26, Iss 1 (2023)

AbstractPurpose HAART has been shown to impair sexual function and penile erection via perturbation of penile redox balance, while zinc has been established to exert antioxidant activity. Therefore, this study focused on the role and associated molec

Externí odkaz: https://doaj.org/article/d901140a37bc4ec492238bac952f26fb

Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3

Autor: O A. Afolabi, T M. Akhigbe, R E. Akhigbe, B A. Alabi, O T. Gbolagun, M E. Taiwo, O O. Fakeye, E O. Yusuf

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Activation of caspase 3 has been implicated in the pathogenesis of I/R injury in various organs, but there is a paucity of data on its role in IIRI. Also, no reports were found on the beneficial role of methanolic Moringa oleifera leaf ex

Externí odkaz: https://doaj.org/article/b824f07a3eba44a1b34c6c99fcb8396e

Glutamine-mediated Modulation of XO/uric acid/NF-kB Signaling Pathway Ameliorates Intestinal I/R-induced Bacterial Translocation and Cardiorenal Inflammatory Injury.

Autor: Hamed MA; Department of Medical Laboratory Science, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.; The Brainwill Laboratory, Osogbo, Osun State, Nigeria.; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria., Adegboyega OO; Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria., Ojo OI; Department of Medical Microbiology and Parasitology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria., Akhigbe TM; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.; Breeding and Genetics Unit, Department of Agronomy, Osun State University, Ejigbo Campus, Osun State, Nigeria., Fajuyitan FD; The Brainwill Laboratory, Osogbo, Osun State, Nigeria.; Department of Microbiology, Faculty of Sciences, Federal University Oye-Ekiti, Oye-Ekiti, Ekiti State, Nigeria., Adeyemo OC; The Brainwill Laboratory, Osogbo, Osun State, Nigeria.; Department of Microbiology, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Osun State, Nigeria., Odebunmi TF; The Brainwill Laboratory, Osogbo, Osun State, Nigeria.; Department of Microbiology, Faculty of Sciences, Federal University Oye-Ekiti, Oye-Ekiti, Ekiti State, Nigeria., Adeniyi OS; The Brainwill Laboratory, Osogbo, Osun State, Nigeria.; Department of Microbiology, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Osun State, Nigeria., Omole IA; The Brainwill Laboratory, Osogbo, Osun State, Nigeria.; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria., Akhigbe RE; Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria. reakhigbe@lautech.edu.ng.; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria. reakhigbe@lautech.edu.ng.

Publikováno v: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Jun; Vol. 82 (2), pp. 1007-1018. Date of Electronic Publication: 2024 Mar 26.

Proton Pump Dysfunction and Upregulation of Caspase-3 Activity via Oxidative-Sensitive Signaling Mediate Rohypnol-Induced Testicular Toxicity.

Autor: Ajayi, A. F.¹ (AUTHOR), Oluwole, D. T.² (AUTHOR), Akhigbe, R. E.^1,3 (AUTHOR), Hamed, M. A.^3,4,5 (AUTHOR), Ajayi, L. O.⁶ (AUTHOR)

Publikováno v: Andrologia. 4/11/2023, p1-15. 15p.