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Autor: W R Shehee, T M Townes, J B Whitney rd, A Leder, Jada Lewis, R A Popp, C Paszty, Oliver Smithies, E M Rubin

Publikováno v: Biochemical Genetics. 36:65-77

The hematology of the laboratory mouse has been well characterized. Normal genetic differences at the alpha- and beta-globin gene loci serve as useful markers for a wide variety of types of experimental studies. There are a number of naturally occurr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35a2c86dc6fe79d84008e3b55b9913f9
https://doi.org/10.1023/a:1018752219810

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Activation of delta-globin gene expression by erythroid Krupple-like factor: a potential approach for gene therapy of sickle cell disease

Autor: D, Donze, P H, Jeancake, T M, Townes

Publikováno v: Blood. 88(10)

Hemoglobin A2 (HbA2; alpha 2 delta 2) is a powerful inhibitor of HbS (alpha 2 beta 2(3)) polymerization. However, HbA2 levels are normally low in sickle cell patients. We show that a major reason for low delta-globin gene expression is the defective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3747d9c4de19b3d659a7f3ae946535ce
https://pubmed.ncbi.nlm.nih.gov/8916973

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Stable transduction of recombinant adeno-associated virus into hematopoietic stem cells from normal and sickle cell patients

Autor: M, Lubovy, S, McCune, J Y, Dong, J F, Prchal, T M, Townes, J T, Prchal

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2(1)

Stable introduction of genes into human hematopoietic stem cells with self-renewing potential is a necessary requirement for gene therapy strategies. We have developed an adeno-associated virus (AAV) vector and a partial packaging cell line that prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee180f0689beb93e916c341930a1ff9f
https://pubmed.ncbi.nlm.nih.gov/9078351

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Preparation of recombinant hemoglobin in transgenic mice

Autor: M P, Reilly, S L, McCune, T M, Ryan, T M, Townes, M, Katsumata, T, Asakura

Publikováno v: Methods in enzymology. 231

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::077ffb090786e1c688046aed95d5a946
https://pubmed.ncbi.nlm.nih.gov/8041266

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DNA content, kinetic complexity, and the ploidy question in Candida albicans

Autor: J W Wills, T M Townes, L J Torres-Bauza, W S Riggsby

Publikováno v: Molecular and Cellular Biology. 2:853-862

Candida albicans is a dimorphic fungus that is pathogenic for humans. No sexual cycle has been reported for this fungus, and earlier reports have differed on whether typical strains of C. albicans are haploid or diploid. Previous estimates of the DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a6987fa70c728d652bdf90c104e5d3
https://doi.org/10.1128/mcb.2.7.853

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Structural organization of the alpha and beta globin loci of the goat

Autor: J B, Lingrel, T M, Townes, S G, Shapiro, S M, Wernke, P A, Liberator, A G, Menon

Publikováno v: Progress in clinical and biological research. 191

Goats switch their hemoglobins during development in a manner similar to humans and thus provide a useful model system for studying the control of hemoglobin synthesis. Initially, goats synthesize embryonic hemoglobin, zeta 2 epsilon 2, which is repl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89e1a547a03ff8d6b44e5ea8f55a33d5
https://pubmed.ncbi.nlm.nih.gov/3901040

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Duplication of a four-gene set during the evolution of the goat beta-globin locus produced genes now expressed differentially in development

Autor: T M, Townes, S G, Shapiro, S M, Wernke, J B, Lingrel

Publikováno v: The Journal of biological chemistry. 259(3)

Genomic clones which link the goat preadult (beta C) and adult (beta A) beta-globin genes have been isolated. These overlapping clones contain a previously unidentified embryonic like globin gene (epsilon III) and establish the following linkage map

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https://pubmed.ncbi.nlm.nih.gov/6693438

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Sequence and linkage of the goat epsilon I and epsilon II beta-globin genes

Autor: S G, Shapiro, E A, Schon, T M, Townes, J B, Lingrel

Publikováno v: Journal of molecular biology. 169(1)

Overlapping clones containing beta-globin genes have been isolated from a goat genomic library which establish the linkage arrangement 5'-epsilon I-epsilon II-psi beta X-beta C-3'. The complete nucleotide sequence of the epsilon I and epsilon II gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e70cb10416977208e6488577720d3d82
https://pubmed.ncbi.nlm.nih.gov/6312053

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