FOUND Trial: randomised controlled trial study protocol for case finding of obstructive sleep apnoea in primary care using a novel device

Autor: Jeremy Dale, Emma Scott, A Smith, Francesco P Cappuccio, Anne Smith, Ly-Mee Yu, R Harrison, A Ali, Michelle A Miller, J Harris, C Carr, A Hare, Peter Auguste, M Miller, J Dale, N Siriwardena, E Scott, C Rogers, L-M Yu, P S Sever, S Prakash, T J Peters, A Grove, T M MacDonald, K Hope, Asad Ali, C Taggart, T Quinnell, F P Cappuccio, J Guest, Jenna Grabey, Milensu Shanyinde, Patricia Apenteng, Kath Hope, I Mcleod, P Auguste, P Apenteng, O Dessi, O Llion, J Rahman, E Buckingham, J Chalk, J Grabey, M Shanyinde, L Costello, S Elwell

Publikováno v: BMJ Open, Vol 14, Iss 7 (2024)

Introduction Obstructive sleep apnoea (OSA) is a common, but underdiagnosed, sleep disorder. If untreated, it leads to poor health outcomes, including Alzheimer’s disease, cancer, cardiovascular disease and all-cause mortality. Our aim is to determ

Externí odkaz: https://doaj.org/article/f8216baa35374a3e8415630d0fa6f0a3

Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): A large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia

Autor: T. M. MacDonald, I. Ford, G. Nuki, I. S. Mackenzie, R. De Caterina, E. Findlay, J. Hallas, C. J. Hawkey, S. Ralston, M. Walters, J. Webster, J. McMurray, F. Perez Ruiz, C. G. Jennings, T. MacDonald, I. Mackenzie, C. Hawkey, F. Perez-Ruiz, A. Maseri, G. Murray, H. Bird, M. Petrie, M. MacDonald, P. Jhund, W. Saywood, R. Flynn, S. Kean

Publikováno v: Europe PubMed Central
MacDonald, T M, Ford, I, Nuki, G, Mackenzie, I S, De Caterina, R, Findlay, E, Hallas, J, Hawkey, C J, Ralston, S, Walters, M, Webster, J, McMurray, J, Perez Ruiz, F & Jennings, C G 2014, ' Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST) : a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia ', BMJ Open, vol. 4, no. 7, pp. e005354 . https://doi.org/10.1136/bmjopen-2014-005354
MacDonald, T M, Ford, I, Nuki, G, Mackenzie, I S, De Caterina, R, Findlay, E, Hallas, J, Hawkey, C J, Ralston, S, Walters, M, Webster, J, McMurray, J, Ruiz, F P & Jennings, C G 2014, ' Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia ', B M J Open, vol. 4, no. 7, e005354 . https://doi.org/10.1136/bmjopen-2014-005354
BMJ Open

Introduction: Gout affects 2.5% of the UK's adult population and is now the most common type of inflammatory arthritis. The long-term management of gout requires reduction of serum urate levels and this is most often achieved with use of xanthine oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8da2d78b142b7212c01e8f5196c18fe
https://acuresearchbank.acu.edu.au/item/8708y/protocol-of-the-febuxostat-versus-allopurinol-streamlined-trial-fast-a-large-prospective-randomised-open-blinded-endpoint-study-comparing-the-cardiovascular-safety-of-allopurinol-and-febuxostat-in

Antiplatelet drug interactions

Autor: I S, Mackenzie, M W H, Coughtrie, T M, MacDonald, L, Wei

Publikováno v: Journal of internal medicine. 268(6)

Both laboratory studies in healthy volunteers and clinical studies have suggested adverse interactions between antiplatelet drugs and other commonly used medications. Interactions described include those between aspirin and ibuprofen, aspirin and oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92afe70e3ee76fcf333ac875181c754e
https://pubmed.ncbi.nlm.nih.gov/21073556

The association between coeliac disease and cardiovascular disease

Autor: L, Wei, E, Spiers, N, Reynolds, S, Walsh, T, Fahey, T M, MacDonald

Publikováno v: Alimentary pharmacologytherapeutics. 27(6)

Coeliac disease is more prevalent than was previously thought. The association between coeliac disease and cardiovascular outcome is not clear.To investigate whether coeliac disease patients have an increased risk of cardiovascular events.A community

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6bf68422d61f82b4cd6fef5b6c9f92bd
https://pubmed.ncbi.nlm.nih.gov/18162081

Drug exposure risk windows and unexposed comparator groups for cohort studies in pharmacoepidemiology

Autor: A D, McMahon, J M, Evans, M M, McGilchrist, D G, McDevitt, T M, MacDonald

Publikováno v: Pharmacoepidemiology and drug safety. 7(4)

To determine the appropriate size of risk windows in both exposed and unexposed sub-cohorts.Data was taken from a previous study of upper gastrointestinal haemorrhage and perforation. The length of each prescription for NSAIDs was estimated. The risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63ba003a81f987b8580e3ad099841352
https://pubmed.ncbi.nlm.nih.gov/15073990