Zobrazeno 1 - 10
of 40
pro vyhledávání: '"T M Aune"'
Autor:
T M Aune, R A Flavell
Publikováno v:
The Journal of Immunology. 159:36-43
Acquiring the ability to selectively produce IFN-gamma or IL-4 is a fundamental property of the immune system and enables T cell subsets (Th1, Th2) to deliver their effector functions. To create an experimental system to examine regulation of critica
Publikováno v:
The Journal of Immunology. 153:489-498
The serotonin (5HT1A) receptor subtype is one member of the 5HT1 receptor family and is constitutively expressed on Jurkat cells and is elevated on human T lymphocytes after mitogenic activation. Published reports show that human T lymphocytes and mo
Publikováno v:
The Journal of Immunology. 151:6036-6042
Regulation of lymphocyte responses to activation of the CD3/TCR complex by other cell surface proteins expressed on lymphocytes is a well established phenomenon. CD44 is an example of such a cell surface protein. Anti-CD44 mAb have been identified wh
Publikováno v:
The Journal of Immunology. 151:1175-1183
The neurotransmitter, serotonin (5-hydroxytryptamine, 5HT), has been shown to affect function of cells of the immune system. More recently, specific 5HT receptors have been identified and partially characterized on Jurkat cells. Results presented her
Publikováno v:
The Journal of Immunology. 147:2493-2499
The CD44 molecule, also known as Hermes lymphocyte homing receptor, human Pgp-1, and extracellular matrix receptor III, has been shown to play a role in T cell adhesion and activation. Specifically, anti-CD44 mAb block binding of lymphocytes to high
Publikováno v:
The Journal of Immunology. 145:1826-1831
Serotonin (5-hydroxytryptamine) (5HT) a neurotransmitter and vasoactive amine, is a major storage product of platelets that are released at sites of inflammation. Several different subtypes of serotonin receptors have been defined. 5HT receptors have
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 35(12)
Atopic diseases, resulting from hypersensitivity to a wide variety of allergens, affect 10-20% of the population. Immunotherapy is an effective treatment for atopic diseases, but its mechanisms are not fully understood.We studied gene expression prof
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(2)
IFN-gamma is a key regulatory cytokine of the immune system. Reporter transgenic mice expressing the luciferase gene under the control of separate TCR-response elements (TCR-RE) from the IFN-gamma promoter or expressing the green fluorescent protein
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(10)
Although the transcriptional basis for states of unresponsiveness in primary T cells is unclear, tolerant B lymphocytes exhibit inhibition of both c-Jun N-terminal kinase induction and IkappaBalpha (inhibitor of NF-kappaBalpha) degradation, leading t
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(11)
Before they can deliver their effector functions, CD4+ Th cells must differentiate into Th1 or Th2 subsets. We have prepared reporter transgenic mice that express the luciferase gene under the control of proximal (prox.IFN-gamma) and distal (dist.IFN