Zobrazeno 1 - 8 of 8 pro vyhledávání: '"T M, Kubiak"'
1
Use of the HIV-1 protease for excision of growth-hormone-releasing factor from synthetic and recombinant peptide precursors
Autor: A G, Tomasselli, A A, Mildner, D J, Paddock, J S, Wheeler, T M, Kubiak, R A, Martin, W M, Moseley, J E, Mott, M C, White, J W, Leone, R L, Heinrikson
Publikováno v: Biotechnology and applied biochemistry. 26(1)
An autolysis-resistant mutant of the HIV-I protease was employed for removal of metabolically stabilized and highly bioactive analogues of bovine growth-hormone-releasing factor (bGRF) from their larger either synthetic or recombinant precursors. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a2e78d2462d6b4beb9dd43575269389
https://pubmed.ncbi.nlm.nih.gov/9262002
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2
Metabolism of mouse growth hormone-releasing factor, mGRF(1-42)OH, and selected analogs from the bovine GRF series in mouse and bovine plasma in vitro
Autor: T M, Kubiak, R A, Martin, J W, Leone, D L, Cleary
Publikováno v: Peptide research. 7(3)
The presence of Val2 in mGRF(1-42)OH is unique and, as shown in this study, renders this GRF resistant to plasma DPP-IV, the main enzyme responsible for rapid hydrolysis and inactivation of Ala2-containing GRFs from other species via cleavages betwee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba71fd0157e9c64591529bbbc7bbcf35
https://pubmed.ncbi.nlm.nih.gov/7915920
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7
1H NMR analysis and in vitro bioactivity of Leu27-bGRF(1-29)NH2 and its D-Ala2 and des-(Tyr1-Ala2)-analogs
Autor: D A, Kloosterman, T A, Scahill, R M, Hillman, D L, Cleary, T M, Kubiak
Publikováno v: Peptide research. 4(2)
Relative growth hormone-releasing potencies of bovine growth hormone-releasing factor (bGRF) analogs bGRF(1-44)NH2 (I), Leu27-bGRF(1-29)NH2 (II) and D-Ala2, Leu27-bGRF(1-29)NH2 (III) in in vitro bovine anterior pituitary cell cultures were determined
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a119adcd988700b5da2b78e8a1416c85
https://pubmed.ncbi.nlm.nih.gov/1667740
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8
In vitro metabolic degradation of a bovine growth hormone-releasing factor analog Leu27-bGRF(1-29)NH2 in bovine and porcine plasma. Correlation with plasma dipeptidylpeptidase activity
Autor: T M, Kubiak, C R, Kelly, L F, Krabill
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 17(4)
A bovine growth hormone-releasing factor analog, Leu27-bGRF(1-29)NH2, was rapidly hydrolyzed to Leu27-bGRF(3-29)NH2 when incubated at 0.03 mM with porcine and bovine plasma at 37 degrees C in vitro (t1/2 = 8.4 min and 22.1 min, respectively). The sit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00fa8eeed776b9f0e806120118870875
https://pubmed.ncbi.nlm.nih.gov/2571478
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