Zobrazeno 1 - 4
of 4
pro vyhledávání: '"T M, Harter"'
Publikováno v:
Advances in experimental medicine and biology. 463
Publikováno v:
Advances in experimental medicine and biology. 414
Publikováno v:
The Journal of biological chemistry. 267(34)
Aldose reductase is an NADPH-dependent oxidoreductase that catalyzes the reduction of a broad range of aldehydes, including glucose. Since aldose reductase has been strongly implicated in the development of the chronic complications of diabetes melli
Publikováno v:
The Journal of biological chemistry. 267(34)
In order to study the potential role of cysteinyl residues in catalysis and inhibition of human aldose reductase, mutants containing cysteine to serine substitution at positions 80 (ALR2:C80S), 298 (ALR2:C298S), and 303 (ALR2:C303S) were constructed.