Zobrazeno 1 - 10 of 20 pro vyhledávání: '"T M, Haqqi"'
1
BUB/BnJ (H-2q) is a TCR deletion mutant mouse strain (TCR V beta a, KJ16-) that is susceptible to type II collagen-induced arthritis
Autor: R A Ortman, D Holderbaum, X M Qu, S Banerjee, T M Haqqi
Publikováno v: The Journal of Immunology. 152:4175-4182
Type II collagen-induced arthritis (CIA) in mice is an animal model of autoimmune inflammatory arthritis. Arthritis is induced in susceptible strains of mice (H-2q and H-2r) after immunization with heterologous or autologous type II collagen in CFA.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b250c3abd5efee46d777640b4deb0e8f
https://doi.org/10.4049/jimmunol.152.8.4175
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2
Immunization with TCR Vbeta10 peptide reduces the frequency of type-II collagen-specific Th1 type T cells in BUB/BnJ (H-2q) mice
Autor: D D, Anthony, P S, Heeger, T M, Haqqi
Publikováno v: Clinical and experimental rheumatology. 19(4)
Collagen induced arthritis (CIA) in mice is mediated by synergistic T cell and humoral immune responses specific for type II collagen (CII). We have previously shown that in arthritic joints of BUB mice (TCR Vbetaa, H-2q) the TCR repertoire is enrich
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea30ceb145b059cc2710009a4ea70a72
https://pubmed.ncbi.nlm.nih.gov/11491493
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5
Experimental autoimmune myasthenia gravis in B10.BV8S2 transgenic mice: preferential usage of TCRAV1 gene by lymphocytes responding to acetylcholine receptor
Autor: R, Kaul, B, Wu, E, Goluszko, C, Deng, V, Dedhia, G H, Nabozny, C S, David, I J, Rimm, M, Shenoy, T M, Haqqi, P, Christadoss
Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(12)
Multiple TCRBV genes have been implicated in experimental autoimmune myasthenia gravis (EAMG) pathogenesis in susceptible H-2(b) strains of mice. We studied the contribution of specific TCRBV and AV genes in EAMG pathogenesis using B10.BV8S2 transgen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6013387adbce08134d7bdc82cdf2bf6
https://pubmed.ncbi.nlm.nih.gov/9190955
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6
OP0123 In Human Chondrocytes DNMT-1 Plays a Key Role in the Expression of Several Genes Associated with the Pathogenesis of Osteoarthritis
Autor: T. M. Haqqi, N. Akhtar
Publikováno v: Annals of the Rheumatic Diseases. 72:A93.1-A93
Background Recent evidence points to chromatin remodeling as a key event in the expression of several genes associated with OA pathogenesis. IL-1β is the principal cytokine involved in cartilage catabolism in OA but whether it induces chromatin remo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77c7402dd302ceecf54ab3934ca22ef3
https://doi.org/10.1136/annrheumdis-2013-eular.328
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7
FRI0041 Pro-inflammatory cytokines IL-1β and tnf-α regulate the genomic 5-hydroxymethylcytosine levels by modulating the expression and activity of tet-1 and idhs in human oa chondrocytes
Autor: A. Haseeb, T. M. Haqqi
Publikováno v: Annals of the Rheumatic Diseases. 72:A381.3-A382
Background 5-hydroxymethyl cytosine (5-hmC) was recently discovered as a new epigenetic mark widely distributed in all types of tissues with varying degrees of abundance. 5-hmC is formed by the oxidation of 5-mC by ten-eleven translocation (TET) fami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45a9d8cdd7f94e8e28583170be6955d0
https://doi.org/10.1136/annrheumdis-2013-eular.1169
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8
Hereditary osteoarthritis with mild spondyloepiphyseal dysplasia--are there 'hot spots' on COL2A1?
Autor: J F, Bleasel, D, Holderbaum, V, Mallock, T M, Haqqi, H J, Williams, R W, Moskowitz
Publikováno v: The Journal of rheumatology. 23(9)
To define the genetic basis of a family with an autosomal, dominantly inherited form of spondyloepiphyseal dysplasia (SED) associated with tall stature.A 6 generation family with early onset osteoarthritis (OA) associated with mild SED was studied. 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53498d67cb72acadb10c57dd6586b2d8
https://pubmed.ncbi.nlm.nih.gov/8877930
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9
Type II procollagen gene (COL2A1) mutation in exon 11 associated with spondyloepiphyseal dysplasia, tall stature and precocious osteoarthritis
Autor: J F, Bleasel, A, Bisagni-Faure, D, Holderbaum, M C, Vacher-Lavenu, T M, Haqqi, R W, Moskowitz, C J, Menkes
Publikováno v: The Journal of rheumatology. 22(2)
To define the clinical, pathological and molecular genetic characteristics of a family with mild spondyloepiphyseal dysplasia (SED) and precocious osteoarthritis.The proband was a 46-year-old man with precocious generalized OA, tall stature, mild cho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6c99d5916b8b6ab8036d927e718ace3
https://pubmed.ncbi.nlm.nih.gov/7738948
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10
Clinical correlations of osteoarthritis associated with single base mutations in the type II procollagen gene
Autor: J F, Bleasel, D, Holderbaum, T M, Haqqi, R W, Moskowitz
Publikováno v: The Journal of rheumatology. Supplement. 43
There are increasing numbers of mutations described in the gene for type II collagen (COL2A1). Recently, COL2A1 mutations were shown to be associated with milder forms of chondrodysplasia, which may present with precocious generalized osteoarthritis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85dda35eaff32362a597c61631a26922
https://pubmed.ncbi.nlm.nih.gov/7752131
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