Výsledky vyhledávání

Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2',2'-difluoro-2'-deoxycytidine (Gemcitabine)

Autor: T S, Lawrence, E Y, Chang, T M, Hahn, D S, Shewach

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(5)

We have shown that 2',2'-difluoro-2'-deoxycytidine (dFdCyd; Gemcitabine), a deoxycytidine analogue, is a potent radiation sensitizer when cells are exposed to it continuously for16 h in low concentrations (in the range of 10 nM). However, the most co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f926093f4cd1f8738ee160c7cd6746a
https://pubmed.ncbi.nlm.nih.gov/9815749

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Metabolism of 2',2'-difluoro-2'-deoxycytidine and radiation sensitization of human colon carcinoma cells

Autor: D S, Shewach, T M, Hahn, E, Chang, L W, Hertel, T S, Lawrence

Publikováno v: Cancer research. 54(12)

Difluorodeoxycytidine (dFdCyd) is a new antimetabolite with clinical activity in patients with solid tumors but not leukemias. We have studied the metabolism, cytotoxicity, and radiosensitizing properties of dFdCyd in HT-29 human colon carcinoma cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dda5962e6a8c9c9f9891f6e447d5e116
https://pubmed.ncbi.nlm.nih.gov/8205542

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Functional characterization of a unique liver gene promoter

Autor: Y, Wang, T M, Hahn, S Y, Tsai, S L, Woo

Publikováno v: The Journal of biological chemistry. 269(12)

Human phenylalanine hydroxylase (PAH) is specifically expressed in the liver to convert L-phenylalanine to L-tyrosine. Deficiency of the PAH enzyme causes classic phenylketonuria, a common genetic disorder. The human PAH gene has a TATA-less promoter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ef2cd9d6f0cc9d5c2882fed100d2547
https://pubmed.ncbi.nlm.nih.gov/8132651

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Tissue- and development-specific expression of the human phenylalanine hydroxylase/chloramphenicol acetyltransferase fusion gene in transgenic mice

Autor: Y, Wang, J L, DeMayo, T M, Hahn, M J, Finegold, D S, Konecki, U, Lichter-Konecki, S L, Woo

Publikováno v: The Journal of biological chemistry. 267(21)

Human phenylalanine hydroxylase (PAH) catalyzes the conversion of L-phenylalanine to L-tyrosine. Deficiency of this enzyme results in phenylketonuria, a common genetic disorder of amino acid metabolism that causes severe mental retardation. In primat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91c6a6bb840ab208d72a20b63e1234f8
https://pubmed.ncbi.nlm.nih.gov/1321825

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