Výsledky vyhledávání - "T M, Coffman"

Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse

Autor: C, Nataraj, D W, Thomas, S L, Tilley, M T, Nguyen, R, Mannon, B H, Koller, T M, Coffman

Publikováno v: The Journal of clinical investigation. 108(8)

Production of prostaglandin E(2) (PGE(2)) is enhanced during inflammation, and this lipid mediator can dramatically modulate immune responses. There are four receptors for PGE(2) (EP1-EP4) with unique patterns of expression and different coupling to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c73bb675f8cd1b2dd85505405d110c9
https://pubmed.ncbi.nlm.nih.gov/11602631

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Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts

Autor: R B, Mannon, C, Doyle, R, Griffiths, M, Bustos, J L, Platt, T M, Coffman

Publikováno v: Transplantation. 69(10)

During renal allograft rejection, expression of MHC class II antigens is up-regulated on the parenchymal cells of the kidney. This up-regulation of MHC class II proteins may stimulate the intragraft alloimmune response by promoting their recognition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac8c9ec33c9b9ad3dece1bd2036ec427
https://pubmed.ncbi.nlm.nih.gov/10852613

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Vasoconstrictor responses in thromboxane receptor knockout mice: tubuloglomerular feedback and ureteral obstruction

Autor: J, Schnermann, T, Traynor, H, Pohl, D W, Thomas, T M, Coffman, J P, Briggs

Publikováno v: Acta physiologica Scandinavica. 168(1)

The role of thromboxane (TP) in the vasoconstriction induced by tubuloglomerular feedback or 18-h ureteral obstruction was studied in wild type mice (TP +/+), and in heterozygous (TP +/-) and homozygous TP receptor knockout mice (TPR -/-). TGF functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::53c67128ea3036ccc46912ba18d53872
https://pubmed.ncbi.nlm.nih.gov/10691801

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The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology

Autor: J F, Neylan, M H, Sayegh, T M, Coffman, G M, Danovitch, A M, Krensky, T B, Strom, L A, Turka, W E, Harmon

Publikováno v: Journal of the American Society of Nephrology : JASN. 10(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52d37e3d66b5c9a97d7321c5df25664d
https://pubmed.ncbi.nlm.nih.gov/10505702

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Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice

Autor: J L, Goulet, R C, Griffiths, P, Ruiz, R F, Spurney, D S, Pisetsky, B H, Koller, T M, Coffman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(1)

Leukotrienes, the 5-lipoxygenase (5LO) products of arachidonic acid metabolism, have many proinflammatory actions that have been implicated in the pathogenesis of a variety of inflammatory diseases. To investigate the role of LTs in autoimmune diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b7a56783103c72df38a676f4ac86004
https://pubmed.ncbi.nlm.nih.gov/10384136

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Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice

Autor: X, Ruan, K E, Purdy, M I, Oliverio, T M, Coffman, W J, Arendshorst

Publikováno v: Journal of the American Society of Nephrology : JASN. 10

This study determined the inhibitory effect of the angiotensin II (AngII) type I (AT1) receptor blocker candesartan on renal vascular reactivity in vivo. Reactivity to AngII before and during candesartan administration was assessed by measuring (by e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::432075678800181b0c29c940c2ee45ea
https://pubmed.ncbi.nlm.nih.gov/9892164

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The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line

Autor: R F, Spurney, T M, Coffman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 283(1)

To investigate regulatory domains of the thromboxane A2 (TxA2) receptor, we constructed a truncated form of the mouse TxA2 receptor and expressed it in a mesangial cell line. The mutant receptor lacked 22 amino acids in the C-terminus including four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8278eb2750dcee1a5b52becd7e928d6
https://pubmed.ncbi.nlm.nih.gov/9336326

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A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor

Autor: T M, Coffman

Publikováno v: Seminars in nephrology. 17(5)

The ability to create targeted mutations in the mouse genome using homologous recombination in embryonic stem cells (gene targeting) has proved to be an extremely useful experimental approach. Recently, mouse lines have been produced with targeted di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::054a21f8c01253c66ce9892385edfb77
https://pubmed.ncbi.nlm.nih.gov/9316208

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The intragraft CD8+ T cell response in renal allograft rejection in the mouse

Autor: R B, Mannon, B L, Kotzin, E, Roper, C, Nataraj, R J, Kurlander, T M, Coffman

Publikováno v: Transplantation. 62(1)

To identify the role of donor class I alloantigens in regulating the CD8+ T cell response to a kidney allograft, we analyzed and compared the CD8+ infiltrate in kidney transplants from MHC class I-deficient (class I-) mouse donors and class I+ contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa6a41bbcebaec323c3747f6471b52e1
https://pubmed.ncbi.nlm.nih.gov/8693553

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