Zobrazeno 1 - 5
of 5
pro vyhledávání: '"T M, Beaufort"'
Publikováno v:
Anesthesiology. 94:270-279
Background Hypothermia prolongs the time course of action of nondepolarizing muscle relaxants. It is not known whether this prolongation is caused by a reduced rate of extrahepatic distribution or elimination, liver uptake, metabolic clearance, or bi
Publikováno v:
Drugs. 61:919-942
Rapacuronium bromide (rapacuronium; ORG-9487) is a nondepolarising muscle relaxant (NMBA) with a low potency [90% effective dose (ED90) 1 mg/kg], which to some extent is responsible for its rapid onset of action. Because of the high plasma clearance
Publikováno v:
Anesthesiology. 90:477-483
Background It is not known whether the lungs influence the early pharmacokinetics of muscle relaxants and, if they do, whether differences in pulmonary uptake contribute to the differences in potency and/or onset time among muscle relaxants. Because
Autor:
M. C. Houwertjes, T. M. Beaufort, U. W. Kleef, J. M. K. H. Wierda, K. Kuizenga, Johannes H. Proost
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 27:173-190
In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore, investigators have to extrapolate the plasma concentration to Time 0. Extrapolation, however,
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 27(2)
In pharmacokinetic/pharmacodynamic (PK/PD) modeling the first blood sample is usually taken 1 to 2 min after drug administration (late sampling). Therefore, investigators have to extrapolate the plasma concentration to Time 0. Extrapolation, however,