Zobrazeno 1 - 10
of 77
pro vyhledávání: '"T L Rothstein"'
Publikováno v:
The Journal of Immunology. 159:4834-4839
Primary murine splenic B cells are rendered sensitive or resistant to Fas-mediated apoptosis in a receptor-specific fashion. B cells stimulated though CD40 are Fas sensitive unless they also receive a signal though surface Ig that produces a state of
Publikováno v:
The Journal of Immunology. 159:4350-4355
Cross-linking CD40 mediates B lymphocyte growth and differentiation and regulates cell death pathways by an unknown mechanism. Previous reports have suggested that protein tyrosine kinase activity is critical for CD40-mediated biologic responses. We
Autor:
L Huo, T L Rothstein
Publikováno v:
The Journal of Immunology. 157:3812-3818
The murine fra-1 gene, encoding Fos-related Ag 1, was isolated from a splenic cDNA library and sequenced. Murine fra-1 was highly homologous to rat and human fra-1. Oligonucleotide primers based on the murine sequence were used to construct a quantit
Publikováno v:
The Journal of Immunology. 157:2749-2753
Activated B cells express Fas (CD95) and are targets for apoptosis induced by CD4+ Th1 effector cells that kill in a Fas-dependent fashion. We report here that IL-4 reverses the susceptibility to Fas-mediated apoptosis that characterizes CD40-stimula
Publikováno v:
The Journal of Immunology. 157:2299-2309
The regulation of the STAT1 alpha transcription factor was assessed during B cell activation induced by cross-linking the surface IgM Ag receptor. Surface Ig ligation or pharmacologic stimulation with PMA and ionomycin resulted in the delayed (2-3 h
Autor:
L C Foote, T J Schneider, G M Fischer, J K Wang, B Rasmussen, K A Campbell, D H Lynch, S T Ju, A Marshak-Rothstein, T L Rothstein
Publikováno v:
The Journal of Immunology. 157:1878-1885
CD40 ligand-activated B cells are sensitive targets for CD4+ Th1 effector cells that kill in a Fas-dependent fashion. Susceptibility to apoptosis is counteracted by Ag receptor binding that produces a state of resistance to Fas engagement in otherwis
Publikováno v:
The Journal of Immunology. 157:39-47
The signal transducer and activator of transcription (STAT) family of transcription factors is triggered by cytokine and growth factor receptors in a number of cell types, and binds to a consensus sequence defined in part by the IFN-gamma activation
Publikováno v:
The Journal of Immunology. 157:81-86
Engagement of surface IgM (sIgM) on WEHI 231 murine B lymphoma cells leads to abortive activation and apoptosis, suggesting that this cell line may represent a model for tolerance. Loss of viability in these cells is preceded by an early increase in
Publikováno v:
The Journal of Immunology. 155:3722-3725
CD40L, a membrane protein of activated T cells, interacts with the B cell receptor CD40. This interaction has been implicated in the rescue of germinal center B cells from apoptosis and in the rescue of WEHI-231 B lymphoma cells from sIg-induced apop
Autor:
L Huo, T L Rothstein
Publikováno v:
The Journal of Immunology. 154:3300-3309
The inducible nuclear transcription factor complex, AP-1, typically consists of heterodimers between Jun and Fos proteins. Although components are drawn from families of related molecules, little is known about the physiologic regulation of jun- and