Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(II) catalyst

Autor: Fengzhi Zhang, Stephen J. Walsh, Moni K. Gupta, Gonçalo J. L. Bernardes, Martin Welch, Elizabeth C. Frye, Terence T.-L. Kwan, Omar Boutureira, Hannah F. Sore, Jason W. Chin, Yuteng Wu, David R. Spring, Stephen Wallace, Warren R. J. D. Galloway

Publikováno v: Kwan, T T-L, Boutureira, O, Frye, E C, Walsh, S J, Gupta, M K, Wallace, S, Wu, Y, Zhang, F, Sore, H F, Galloway, W R J D, Chin, J W, Welch, M, Bernardes, G J L & Spring, D R 2017, ' Protein Modification via Alkyne Hydrosilylation Using A Substoichiometric Amount of Ruthenium(II) Catalyst ', Chemical Science, vol. 8, no. 5, pp. 3871-3878 . https://doi.org/10.1039/C6SC05313K
Chemical Science

Transition metal catalysis has emerged as a powerful strategy to expand synthetic flexibility of protein modification. Herein, we report a cationic Ru(II) system that enables the first example of alkyne hydrosilylation between dimethylarylsilanes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08066b1b85dbf3c024d2a842b59975fd
https://www.repository.cam.ac.uk/handle/1810/264391

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Autor: Matthias G J, Baud, Enrique, Lin-Shiao, Teresa, Cardote, Cynthia, Tallant, Annica, Pschibul, Kwok-Ho, Chan, Michael, Zengerle, Jordi R, Garcia, Terence T-L, Kwan, Fleur M, Ferguson, Alessio, Ciulli

Publikováno v: Science (New York, N.Y.). 346(6209)

Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::623610fe88eae7c2364454f76f831f01
https://pubmed.ncbi.nlm.nih.gov/25699317

Population-based information on emergency colorectal surgery and evaluation on effect of operative volume on mortality

Autor: E. Shung, Wai Lun Law, T. L. Kwan, A. Wai, Y. C. Siu, W. C. Yuen, C. M. Lam, F. Lai

Publikováno v: World journal of surgery. 32(9)

Introduction Population-based information on emergency surgery for colorectal conditions was limited. The present study was designed to review comprehensively the outcomes of emergency colectomy in Hong Kong population and evaluate the effect of case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a11fdf04f8647be87b31aade8a0303b
https://pubmed.ncbi.nlm.nih.gov/18560933

Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors

Autor: T L Kwan, C K Ng, F Y Y Ng, T S To, J W M Chan, T Y W Mok, Yiong Huak Chan

Publikováno v: Thorax

Background: The long term physiological and radiological outcomes of SARS survivors and their possible determinants are uncertain. Methods: SARS survivors in a follow up clinic in a regional hospital underwent high resolution computed tomography (HRC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0cfc4872699e5e5d3419059986e8fe
https://pubmed.ncbi.nlm.nih.gov/15454656

Authors' reply: Evaluation of various POSSUM models for predicting mortality in patients undergoing elective oesophagectomy for carcinoma (Br J Surg2007; 94: 1172–1178)

Autor: T. L. Kwan

Publikováno v: British Journal of Surgery. 95:127-127

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bee284ac283bce71b91d34c21339bdb8
https://doi.org/10.1002/bjs.6121