Výsledky vyhledávání - "T L Innerarity"

Akademický článek

Association of genetic variations in apolipoprotein B with hypercholesterolemia, coronary artery disease, and receptor binding of low density lipoproteins

Autor: E H Ludwig, P N Hopkins, A Allen, L L Wu, R R Williams, J L Anderson, R H Ward, J M Lalouel, T L Innerarity

Publikováno v: Journal of Lipid Research, Vol 38, Iss 7, Pp 1361-1373 (1997)

To search for unique mutations in the apolipoprotein B (apoB) gene that disrupt the binding of LDL to its receptor and cause hypercholesterolemia, we examined more than 800 patients with high LDL cholesterol levels and/or coronary artery disease (CAD

Externí odkaz: https://doaj.org/article/67689e897eaf42f4a73acc830168b206

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Akademický článek

Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

Autor: K S Arnold, M E Balestra, R M Krauss, L K Curtiss, S G Young, T L Innerarity

Publikováno v: Journal of Lipid Research, Vol 35, Iss 8, Pp 1469-1476 (1994)

Familial defective apolipoprotein B-100 (FDB) is a genetic disorder apparently caused by a single amino acid substitution (Arg3500–>Gln) that disrupts the binding of low density lipoproteins (LDL) to the LDL receptor. The plasma of FDB heterozygote

Externí odkaz: https://doaj.org/article/b80692fa64d2496c8a5b1a82a01aefe9

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Akademický článek

Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species

Autor: R W Mahley, T L Innerarity, M S Brown, Y K Ho, J L Goldstein

Publikováno v: Journal of Lipid Research, Vol 21, Iss 8, Pp 970-980 (1980)

Animals fed cholesterol accumulate several types of cholesterol-rich lipoproteins in their plasma and ultimately develop cholesteryl ester deposition in tissue macrophages. Previous studies in the cholesterol-fed dog have shown that one class of chol

Externí odkaz: https://doaj.org/article/bf4c9179cdf44d02acad4d4ce982f548

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Akademický článek

Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.

Autor: M Fainaru, R W Mahley, R L Hamilton, T L Innerarity

Publikováno v: Journal of Lipid Research, Vol 23, Iss 5, Pp 702-714 (1982)

Cholesteryl ester-rich beta-very low density lipoproteins (beta-VLDL) are beta-migrating lipoproteins that accumulate in the d < 1.006 g/ml fraction of plasma from cholesterol-fed animals and from patients with Type III hyperlipoproteinemia. They can

Externí odkaz: https://doaj.org/article/1a2a421d095b4c5ca2f680589109e653

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Akademický článek

Plasma lipoproteins: apolipoprotein structure and function.

Autor: R W Mahley, T L Innerarity, S C Rall, Jr, K H Weisgraber

Publikováno v: Journal of Lipid Research, Vol 25, Iss 12, Pp 1277-1294 (1984)

Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III. Sp

Externí odkaz: https://doaj.org/article/6315e32536c04f099b26da86afa923fb

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Akademický článek

A potential complication in the use of monoclonal antibodies: inhibition of apoB-mediated receptor binding by an anti-apoE antibody.

Autor: R Maurice, Y L Marcel, T L Innerarity, R W Milne

Publikováno v: Journal of Lipid Research, Vol 30, Iss 4, Pp 587-596 (1989)

Monoclonal antibody (Mab) 1D7 is specific for human apolipoprotein (apo) E and blocks binding of lipid-associated apoE to the low density lipoprotein (LDL) receptor. We report here that 1D7 can also block the binding of apoE-free LDL to the LDL recep

Externí odkaz: https://doaj.org/article/74d967de0bc2468c991f13a4c987354d

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Akademický článek

Receptor binding activity of lipid recombinants of apolipoprotein B-100 thrombolytic fragments.

Autor: A Corsini, C H Spilman, T L Innerarity, K S Arnold, S C Rall, Jr, J K Boyles, R W Mahley

Publikováno v: Journal of Lipid Research, Vol 28, Iss 12, Pp 1410-1423 (1987)

Apolipoprotein (apo) B-100, the protein constituent of low density lipoproteins (LDL), is the determinant responsible for LDL binding to the apoB,E(LDL) receptor on cells. The current study was designed to identify the region(s) of apoB-100 that inte

Externí odkaz: https://doaj.org/article/87c96d93b6d6489493836c1589be0789

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Akademický článek

Characterization of lipoprotein receptors on rat Fu5AH hepatoma cells.

Autor: G Friedman, M E Wernette-Hammond, D Y Hui, R W Mahley, T L Innerarity

Publikováno v: Journal of Lipid Research, Vol 28, Iss 12, Pp 1482-1494 (1987)

The rat hepatoma cell line Fu5AH has the unusual property of accumulating massive amounts of cholesteryl ester upon incubation with hypercholesterolemic serum, and especially when incubated with beta-very low density lipoproteins (beta-VLDL) from cho

Externí odkaz: https://doaj.org/article/9c1888809180419c9fbf0476ccc277a5

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Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding

Autor: T L Innerarity, Alan Chait, I Lee, Katherine L. Olin, J Borén, Thomas N. Wight

Publikováno v: Journal of Clinical Investigation. 101:2658-2664

The subendothelial retention of LDLs through their interaction with proteoglycans has been proposed to be a key process in the pathogenesis of atherosclerosis. In vitro studies have identified eight clusters of basic amino acids in delipidated apo-B1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a2efa89255b280bf80e87cbe449cf0
https://doi.org/10.1172/jci2265

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Association of genetic variations in apolipoprotein B with hypercholesterolemia, coronary artery disease, and receptor binding of low density lipoproteins

Autor: R. H. Ward, J L Anderson, E. H. Ludwig, Roger R. Williams, A Allen, T L Innerarity, Lily L. Wu, Paul N. Hopkins, Jean-Marc Lalouel

Publikováno v: Journal of Lipid Research, Vol 38, Iss 7, Pp 1361-1373 (1997)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d4178fdcab7a574c8604b98733226
https://doi.org/10.1016/s0022-2275(20)37419-8

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