Výsledky vyhledávání - "T L Delovitch"

Beta 2-microglobulin induces a conformational change in an MHC class I H chain that occurs intracellularly and is maintained at the cell surface

Autor: U G Danliczyk, T L Delovitch

Publikováno v: The Journal of Immunology. 153:3533-3542

beta 2-microglobulin (beta 2-m) can regulate the cell surface conformation and expression of a class I MHC H chain. To further determine how the intracellular association of beta 2-m with a class I H chain influences the subsequent cell surface confo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78c5e08ddd95d802f6ecd260bee28f66
https://doi.org/10.4049/jimmunol.153.8.3533

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p21ras and protein kinase C function in distinct and interdependent signaling pathways in C3H 10T1/2 fibroblasts

Autor: A. Krook, Tina Haliotis, S K Anderson, Yu Chun Zhou, T. L. Delovitch, D. T. Denhardt, M. J. Rapoport, Hugh F. Pross

Publikováno v: Molecular and Cellular Biology. 13:1471-1479

Both p21ras and protein kinase C (PKC) are believed to function downstream of plasma membrane-associated tyrosine kinases in cellular signal transduction pathways. However, it has remained controversial whether they function in the same pathway and,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69d26473f3c4607bed66ac561e3400e6
https://doi.org/10.1128/mcb.13.3.1471

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Persistence of serum antibodies to 64,000-Mr islet cell protein after onset of type I diabetes

Autor: M. R. Christie, D. Daneman, P. Champagne, T. L. Delovitch

Publikováno v: Diabetes. 39:653-656

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4542f19b51096460403e3cda0999631
https://doi.org/10.2337/diabetes.39.6.653

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Antigen-induced Ca2+ signaling and desensitization in B cells

Autor: A H Lazarus, G B Mills, T L Delovitch

Publikováno v: The Journal of Immunology. 144:4147-4155

Cross-linking of B cell surface Ig (sIg) by anti-Ig results in transmembrane signaling. However, the capacity of a thymus-dependent (TD) Ag to mediate B cell signal transduction has been less well documented. Therefore, we examined Ag-induced intrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bbe81c6eb28cbc131c15bc120e3f158
https://doi.org/10.4049/jimmunol.144.11.4147

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Standardizing Experiments with NOD Mice

Autor: Alberto Signore, T. L. Delovitch, P. E. Beales, Paolo Pozzilli

Publikováno v: Autoimmunity. 24:127-129

We would like to provoke discussion on the standardization of experiments involving NOD mice, with a possible view to an international workshop on the subject at a future date.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa6b516a90803adc935491d5609fea2
https://doi.org/10.3109/08916939609001954

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Cytokines and chemokines in the pathogenesis of murine type 1 diabetes

Autor: C, Meagher, S, Sharif, S, Hussain, M J, Cameron, G A, Arreaza, T L, Delovitch

Publikováno v: Advances in experimental medicine and biology. 520

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7b8df9cb59572bfd4b40f1c39f323d3
https://pubmed.ncbi.nlm.nih.gov/12613577

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Regulation of immune responses by natural killer T cells

Autor: S, Sharif, T L, Delovitch

Publikováno v: Archivum immunologiae et therapiae experimentalis. 49

Natural killer T (NKT) cells, which comprise a minor population of T cells in primary and secondary lymphoid organs, possess phenotypic characteristics of both NK and T cells. NKT cells respond to various external stimuli by an early burst of cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2710150602cfc6f17050141dff8a9b4e
https://pubmed.ncbi.nlm.nih.gov/11603866

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TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway

Autor: K V, Salojin, J, Zhang, T L, Delovitch

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(2)

CD28 costimulation amplifies TCR-dependent signaling in activated T cells, however, the biochemical mechanism(s) by which this occurs is not precisely understood. The small GTPase Rac-1 controls the catalytic activity of the mitogen-activated protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0194fbe37a120126ff3e5e0a7685a1db
https://pubmed.ncbi.nlm.nih.gov/10395678

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p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells

Autor: J, Zhang, K V, Salojin, J X, Gao, M J, Cameron, I, Bergerot, T L, Delovitch

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(7)

Optimal T cell activation requires two signals, one generated by TCR and another by the CD28 costimulatory receptor. In this study, we investigated the regulation of costimulation-induced mitogen-activated protein kinase (MAPK) activation in primary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a6df83903695a04776cd8e23793e55e
https://pubmed.ncbi.nlm.nih.gov/10201899

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