Výsledky vyhledávání - "T L, VandeGiessen"

Pharmacokinetics of the individual enantiomers of cis-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzamide monohydrochloride (U-54494A) in the dog

Autor: W Z, Zhong, M G, Williams, M R, Schuette, T L, Vandegiessen, B W, Jones

Publikováno v: Enantiomer. 1(2)

U-54494A, a racemic mixture of two enantiomers, is being developed in racemic form as an anticonvulsant drug candidate. A comparative pharmacokinetic study with intravenous and oral administration of the two individual enantiomers to the dog was cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52b2772833d398e45bdcf227870e8fe9
https://pubmed.ncbi.nlm.nih.gov/9676281

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First-pass effect of cis-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)- cyclohexyl)-benzamide (U-54494) in rats--a model with multiple cannulas for investigation of gastrointestinal and hepatic metabolism

Autor: W Z, Zhong, M G, Williams, K J, Cook, T L, VandeGiessen, B W, Jones, K E, Rousch

Publikováno v: Pharmaceutical research. 11(11)

A multiple cannulated rat model was utilized to investigate the relative contribution of the gut and liver as sites of first-pass metabolism of orally administered U-54494A, an anticonvulsant drug candidate. Each rat received a dose of U-54494A by or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fff965ea2de774d3b04812d25c4678a4
https://pubmed.ncbi.nlm.nih.gov/7870665

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