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Spectrum of cdk-9 inhibitor activity against HIV-1 replication among various models of chronic and latent infection

Autor: T L, Pisell, O, Ho, G, Lee, S T, Butera

Publikováno v: Antiviral chemistrychemotherapy. 12

The cellular transcription elongation factor, P-TEFb, and its kinase component, cdk-9, have been implicated in the regulation of HIV-1 transactivation and transcription. We tested a panel of demonstrated cdk-9 kinase inhibitors for the ability to blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f17075bed37b811ef71f869ca8b38e06
https://pubmed.ncbi.nlm.nih.gov/11594686

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The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function

Autor: C M, Pariante, B D, Pearce, T L, Pisell, C I, Sanchez, C, Po, C, Su, A H, Miller

Publikováno v: Endocrinology. 140(9)

Proinflammatory cytokines have been shown to influence the expression and function of the glucocorticoid receptor (GR). Specifically, several studies have found that cytokines induce a decrease in GR function, as evidenced by reduced sensitivity to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8471c1ee779ddb442e12e451771980ae
https://pubmed.ncbi.nlm.nih.gov/10465310

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1996 Curt P. Richter Award. Effects of viral infection on corticosterone secretion and glucocorticoid receptor binding in immune tissues

Autor: A H, Miller, R L, Spencer, B D, Pearce, T L, Pisell, P, Tanapat, J J, Leung, F S, Dhabhar, B S, McEwen, C A, Biron

Publikováno v: Psychoneuroendocrinology. 22(6)

During an immune challenge it has been suggested that responding cells secrete cytokines which then stimulate the release of glucocorticoids. Glucocorticoids, in turn, are believed to bind to their receptors in target immune tissues and provide feedb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd3dfe75a96f40a86941aa2b750f3f95
https://pubmed.ncbi.nlm.nih.gov/9364623

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