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Autor: Kim R. Bridle, Gregory J. Anderson, Darrell H. G. Crawford, Claudia Popa, Linda M. Fletcher, T. L. Murphy

Publikováno v: Hepatology. 46:822A-901A

Introduction: Co-toxicity is an important factor in determining the pathogenesis of progressive liver disease. The mRNA expression of the hepatic iron sensor peptide hepcidin, is decreased in human subjects and in animal models of HFE-related hemochr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a48527af63c32ac35bd99497ad85e42d
https://doi.org/10.1002/hep.22022

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AASLD Abstract (pp. 162A–266A)

Autor: Margaret M. Walters, Linda M. Fletcher, T. L. Murphy, Kim R. Bridle, Darrell H. G. Crawford

Publikováno v: Hepatology. 40:676A-735A

Introduction: Oxidative stress plays a pivotal role in the pathogenesis of alcoholic liver disease (ALD). Iron homeostasis has been reported to be altered in ALD and available free iron may catalyse reactions generating reactive oxygen species (ROS).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a394669775c6a9006deab33211438f21
https://doi.org/10.1002/hep.1840400508

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A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption

Autor: Gregory J. Anderson, Andrew T. McKie, David M. Frazer, T. L. Murphy, Chris D. Vulpe, Sarah J. Wilkins, E. M. Becker

Publikováno v: Gut. 52:340-346

Background: A large oral dose of iron will reduce the absorption of a subsequent smaller dose of iron in a phenomenon known as mucosal block. Molecular analysis of this process may provide insights into the regulation of intestinal iron absorption. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697fd5266d48f89762d44b670edbe602
https://doi.org/10.1136/gut.52.3.340

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[Untitled]

Autor: Herman H. Shugart, A. S. Isaev, T. L. Murphy, Anthony C. Janetos, B. E. Orlick, Dmitry Ershov, Eric S. Kasischke, Sergey Bartalev, Nancy H. F. French, G. N. Korovin

Publikováno v: Climatic Change. 55:235-249

Russian boreal forests are subject to frequent wildfires. The resulting combustion of large amounts of biomass not only transforms forest vegetation, but it also creates significant carbon emissions that total, according to some authors, from 35–94

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6aef99da01a335ddcb0e7d8710a550b7
https://doi.org/10.1023/a:1020221123884

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Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

Autor: T. L. Murphy, Natasha Libina, Gregory J. Anderson, Jane Gitschier, Yien-Ming Kuo, L. Cowley, Candice C. Askwith, Chris D. Vulpe

Publikováno v: Nature Genetics. 21:195-199

Iron is essential for many cellular functions; consequently, disturbances of iron homeostasis, leading to either iron deficiency or iron overload, can have significant clinical consequences. Despite the clinical prevalence of these disorders, the mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f03f259836bb9deac56f5827d4a3bc
https://doi.org/10.1038/5979

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Mapping the Gene for Sex-Linked Anemia: An Inherited Defect of Intestinal Iron Absorption in the Mouse

Autor: Gordon D. McLaren, T. L. Murphy, June W. Halliday, Gregory J. Anderson, L. Cowley, Betty A. Evans

Publikováno v: Genomics. 48:34-39

The sex-linked anemic (sla) mouse carries an anemia that results from an inherited defect of intestinal iron absorption and provides an ideal model with which to investigate this poorly understood yet clinically important process. We have precisely m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59299523f4d83f92043e900b0a13ac44
https://doi.org/10.1006/geno.1997.5138

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A Corn Oil-Based Diet Protects Against Combined Ethanol and Iron-Induced Liver Injury in a Mouse Model of Hemochromatosis

Autor: Darrell H. G. Crawford, Gregory J. Anderson, V. Nathan Subramaniam, N. Santrampurwala, Lesley Jaskowski, Denis I. Crane, Andrew D. Clouston, T. L. Murphy, Terrence C. H. Tan, Linda M. Fletcher

Publikováno v: Alcoholism: Clinical and Experimental Research.

Combined iron overload and alcohol may promote synergistic chronic liver injury and toxicity. The role of specific dietary fats in influencing the development of co-toxic alcoholic liver disease needs further evaluation and is investigated in this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587db064545e7dc1ac50f74f7ce6ab5e
https://doi.org/10.1111/acer.12155

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Carbohydrate-deficient transferrin in alcoholics with liver disease

Autor: Kenneth Sosnowski, Patricia L. Featherston, June W. Halliday, Linda M. Fletcher, Stephen H. Caldwell, Mark Kulaga, T. L. Murphy, Xuiming Li, Phillip K. Kiyasu, Rolland C. Dickson

Publikováno v: Journal of Gastroenterology and Hepatology. 10:174-178

To assess the relationship between carbohydrate-deficient transferrin (CDT) and alcoholic liver disease, we measured the ratio of carbohydrate-deficient transferrin to total transferrin (rCDT) in 32 male alcoholics with liver disease (Child-Pugh clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e367e5b5c2e69379d7afa6ca94aa27a
https://doi.org/10.1111/j.1440-1746.1995.tb01074.x

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Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption

Autor: T. L. Murphy, Sarah J. Wilkins, Gregory J. Anderson, Andrew T. McKie, K N Millard, E. M. Becker, David M. Frazer, Chris D. Vulpe

Publikováno v: Biochemical Society Transactions. 30:724-726

Hepcidin is an anti-microbial peptide predicted to be involved in the regulation of intestinal iron absorption. We have examined the relationship between the expression of hepcidin in the liver and the expression of the iron-transport molecules dival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38c49dd49d455dfab229e1db10db9f8
https://doi.org/10.1042/bst0300724

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Identification of cis-Acting Regulatory Elements Controlling Interleukin-4 Gene Expression in T Cells: Roles for NF-Y and NF-ATc

Autor: S J, Szabo, J S, Gold, T L, Murphy, K M, Murphy

Publikováno v: Molecular and Cellular Biology. 13:4793-4805

Activity of the murine interleukin-4 (IL-4) promoter was localized to several cis-acting elements present within the first 300 bp from the transcriptional initiation site. Five repeated elements, P0 to P4, that share the common consensus ATTTTCCNNT w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe167fcbf744a2abb6e8152d59d6daef
https://doi.org/10.1128/mcb.13.8.4793-4805.1993

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