Zobrazeno 1 - 10
of 59
pro vyhledávání: '"T L, Ciardelli"'
Autor:
T L Ciardelli, Fred E. Cohen, Robert A. Nissenson, Gordon J Strewler, M Nilsson, M Ericsson, M.S. Bradley, M Carlquist
Publikováno v:
Journal of Biological Chemistry. 266:1997-2004
Predictive and spectroscopic methods were used to develop a model of the structures of the 1-34 peptides of parathyroid hormone (PTH) and the PTH-related protein (PTHrP). Circular dichroism (CD) studies of bovine PTH-(1-34) and human PTHrP-(1-34)amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ada38362f2357a83bacb349bc41d50
https://doi.org/10.1016/s0021-9258(18)52390-5
https://doi.org/10.1016/s0021-9258(18)52390-5
Autor:
S F, Liparoto, T L, Ciardelli
Publikováno v:
Journal of molecular recognition : JMR. 12(5)
Surface plasmon resonance (SPR) biosensor technology has been a significant addition to the evolution and refinement of methods to study macromolecular interactions. Prior to the advent of SPR, we employed a variety of biochemical and biological tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98091db9b31d0fe6e16ccc453226a87b
https://pubmed.ncbi.nlm.nih.gov/10556880
https://pubmed.ncbi.nlm.nih.gov/10556880
Publikováno v:
Synapse (New York, N.Y.). 27(3)
The chemical interaction that condenses the hyperphosphorylated protein tau in Alzheimer's disease (AD P-tau) into neurofibrillary tangles and cripples synaptic transmission remains unknown. Only beta-sheet, positive ion salt bridges between phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5777bd0b5f5166cd5cdf13799810a866
https://pubmed.ncbi.nlm.nih.gov/9329157
https://pubmed.ncbi.nlm.nih.gov/9329157
Publikováno v:
The Journal of biological chemistry. 271(21)
Site-directed mutagenesis was used to generate point mutations in the diphtheria toxin-related fusion protein, DAB389 interleukin-2 (IL-2). Thr-439, in the IL-2 receptor binding domain of the fusion toxin, was changed to a Pro residue. The resultant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d3b8e97a57c434355d066cfe6d2a32c
https://pubmed.ncbi.nlm.nih.gov/8647806
https://pubmed.ncbi.nlm.nih.gov/8647806
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5dc3a75319b123c3d8032941cc0d2f9f
https://pubmed.ncbi.nlm.nih.gov/8961768
https://pubmed.ncbi.nlm.nih.gov/8961768
Publikováno v:
Molecular pharmacology. 47(1)
Interleukin-2 (IL-2) is an immunoregulatory cytokine whose biological effects are mediated through interaction with specific receptors on the surface of target cells. Due to its presumed role in generating a normal immune response, IL-2 is being eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5842c559269b3d619b3735f659d4dc6
https://pubmed.ncbi.nlm.nih.gov/7838130
https://pubmed.ncbi.nlm.nih.gov/7838130
Autor:
B E, Landgraf, B, Goldstein, D P, Williams, J R, Murphy, T R, Sana, K A, Smith, T L, Ciardelli
Publikováno v:
The Journal of biological chemistry. 267(26)
Interleukin-2 (IL-2) and its receptor complex have become one of the most studied members of a growing family of protein hormones characterized by structural similarities in both ligands and their receptors. Structure-function studies of IL-2 have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d211f2df08677334e4ab038c36c314c4
https://pubmed.ncbi.nlm.nih.gov/1526987
https://pubmed.ncbi.nlm.nih.gov/1526987
Autor:
B, Lee, T L, Ciardelli
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10c7d4ad1a404dc54800babb11e4d8c4
https://pubmed.ncbi.nlm.nih.gov/1475362
https://pubmed.ncbi.nlm.nih.gov/1475362
Publikováno v:
The Journal of biological chemistry. 266(32)
High resolution transmission electron microscopy (TEM) has shown that bovine tau are 2.1 +/- 0.2-nm diameter filaments which are triple-stranded left-hand helical structures composed of three 1.0 +/- 0.2-nm strands. The reported amino acid sequence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f5f29064beb809ff2de4c84143bb66c
https://pubmed.ncbi.nlm.nih.gov/1939223
https://pubmed.ncbi.nlm.nih.gov/1939223
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 310
Studies were conducted in cats to determine whether this species could serve as an animal model for the therapeutic toxicity of recombinant interleukin-2 in humans, and to establish the role of the area postrema in the causation of recombinant interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83ac2006c3eeafbe312243537475fe2a
https://pubmed.ncbi.nlm.nih.gov/1772328
https://pubmed.ncbi.nlm.nih.gov/1772328