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Akademický článek

Isolating Crucial Steps in Induction of Infective Endocarditis With Preclinical Modeling of Host Pathogen Interaction

Autor: Christian Schwarz, Verena Hoerr, Yasemin Töre, Vanessa Hösker, Uwe Hansen, Hélène Van de Vyver, Silke Niemann, Michael T. Kuhlmann, Astrid Jeibmann, Moritz Wildgruber, Cornelius Faber

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Animal models of Staphylococcus aureus infective endocarditis (IE), especially in rodents, are commonly used to investigate the underlying pathogenesis, disease progression, potential diagnostic approaches, and therapeutic treatment. All these models

Externí odkaz: https://doaj.org/article/868c8e406246455da16c847f6910094f

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Akademický článek

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Data from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Autor: Andreas H. Jacobs, Alexandra Winkeler, Michael Schäfers, Sven Hermann, Michael T. Kuhlmann, Cornelius Faber, Andreas Faust, Stefan Wagner, Katrin Schwegmann, Lisa Honold, Sonja Schelhaas, Inga B. Fricke, Lydia Wachsmuth, Thomas Viel, Benoit Thézé, Hayet Pigeon, Bastian Zinnhardt

The tumor microenvironment is highly heterogeneous. For gliomas, the tumor-associated inflammatory response is pivotal to support growth and invasion. Factors of glioma growth, inflammation, and invasion, such as the translocator protein (TSPO) and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ed0385b1ef2e3a703be5c3caddd1b4
https://doi.org/10.1158/0008-5472.c.6509840

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Suppl. Fig. 1: Experimental design. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Gli36dEGFR cells were implanted. Thereafter, two imaging sequences were conducted: In sequence 1, T2w MRI and PET with [18F]DPA-714 was performed, while [18F]BR-351 PET and [18F]FET PET were conducted at day 13 and 14, respectively. In imaging sequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0216f18421d6c4898467c85050d36071
https://doi.org/10.1158/0008-5472.22417415

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Suppl. Fig. 2: Workflow of imaging data co-registration. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

PET and CT images were co-registered using three CT-detectable, molecular sieve spheres (# 1-3) rinsed in radiotracer solution. After segmentation of spheres in the CT image (arrows), PET and CT images were superimposed by using the automated "Landma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ede5696d579d7e0079bf8e5fc54a84
https://doi.org/10.1158/0008-5472.22417412

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Suppl. Fig. 4: Influence of imaging sequence. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

(A) T/B ratios, (B-D) tracer volumes, (E-J) areas of unique tracer uptake and overlapping regions. No significant effect on volumetric data was observed based on the order of imaging experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843dfe71ebb02507a4270e4ee203449
https://doi.org/10.1158/0008-5472.22417406.v1

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Supplementary Figure Legends from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

Supplementary Figure Legends 1-5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2d05a1603fc780b960d8a5daa99d1b
https://doi.org/10.1158/0008-5472.22417400

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Suppl. Fig. 3: Illustration of the applied thresholding. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

(A) An elliptical VOI (yellow) was drawn in the striatum. (B) Another elliptical VOI (green) was placed over the affected hemisphere. (C) After application of a thresholding based on the control VOI. The same original VOIs (left and middle) were used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2777e1bbef7baae06da639c6fe614b
https://doi.org/10.1158/0008-5472.22417409

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Suppl. Fig. 5: Assessment of intra-rater reproducibility of the volumetric relation of [18F]DPA-714 and [18F]FET. from Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake

An exemplary subset of n=6 mice were randomly assessed for intra-rater reproducibility. (A-E) [18F]DPA-714 and [18F]FET images were on two consecutive days repeatedly co-registered. Volumetry was performed twice (coreg 2 and coreg 3) and compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35529d260d0160b3b767f7d08b412e69
https://doi.org/10.1158/0008-5472.22417403

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Akademický článek

Monitoring Endothelin-A Receptor Expression during the Progression of Atherosclerosis

Autor: Miriam Stölting, Christiane Geyer, Anne Helfen, Anke Hahnenkamp, Marco V. Usai, Eva Wardelmann, Michael T. Kuhlmann, Moritz Wildgruber, Carsten Höltke

Publikováno v: Biomedicines, Vol 8, Iss 12, p 538 (2020)

Cardiovascular disease remains the most frequent cause of death worldwide. Atherosclerosis, an underlying cause of cardiovascular disease, is an inflammatory disorder associated with endothelial dysfunction. The endothelin system plays a crucial role

Externí odkaz: https://doaj.org/article/6e88b731bccb451da072d36fb6d1f9f4

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