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pro vyhledávání: '"T Kolasa"'
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Autor:
C. Zhong, G Z Zheng, O El-Kouhen, Gerard B. Fox, R Chang, Prisca Honore, Mario Mezler, A O Stewart, Robert B. Moreland, Pramila Bhatia, S J Baker, T Kolasa, N M Rodell, Michael W. Decker, L N Miller, Jorge D. Brioni, E A Cronin, Katharine L. Chu, M E Uchic, M Patel, J. B. Pan, PR Hollingsworth, Steve McGaraughty, S G Lehto, Joseph P. Mikusa
Publikováno v:
British Journal of Pharmacology. 149:761-774
Background and purpose: To further assess the clinical potential of the blockade of metabotropic glutamate receptors (mGluR1) for the treatment of pain. Experimental approach: We characterized the effects of A-841720, a novel, potent and non-competit
Autor:
M A Terranova, J D Brioni, R Chang, G C Hsieh, T Kolasa, Robert B. Moreland, M Nakane, L N Miller
Publikováno v:
International Journal of Impotence Research. 14:121-127
Nitric oxide (NO) activates corpus cavernosum smooth muscle soluble guanylate cyclase (sGC) and increases the synthesis of cGMP that results in smooth muscle relaxation and ultimately, penile erection. To characterize sGC and define the potential syn
Publikováno v:
International Journal of Impotence Research. 13:240-246
The potential of ATP-sensitive potassium channel openers (KCOs) for the treatment of male erectile dysfunction has recently been suggested based on positive clinical outcomes following intra-cavernosal administration of pinacidil. Agents that increas
Autor:
O, El-Kouhen, S G, Lehto, J B, Pan, R, Chang, S J, Baker, C, Zhong, P R, Hollingsworth, J P, Mikusa, E A, Cronin, K L, Chu, S P, McGaraughty, M E, Uchic, L N, Miller, N M, Rodell, M, Patel, P, Bhatia, M, Mezler, T, Kolasa, G Z, Zheng, G B, Fox, A O, Stewart, M W, Decker, R B, Moreland, J D, Brioni, P, Honore
Publikováno v:
British journal of pharmacology. 149(6)
To further assess the clinical potential of the blockade of metabotropic glutamate receptors (mGluR1) for the treatment of pain.We characterized the effects of A-841720, a novel, potent and non-competitive mGluR1 antagonist in models of pain and of m
Publikováno v:
International Symposium for Testing and Failure Analysis.
In this paper, we will present our solution to the problem of test based fault localization in the failure analysis laboratory environment. The test system described herein is currently used for a number of high power mixed signal application specifi
Publikováno v:
International journal of impotence research. 14(1)
Soluble guanylate cyclase (sGC) is an important enzyme in corpus cavernosum smooth muscle cells as it is one of the regulators of the synthesis of cGMP. The efficacy of sildenafil (Viagra) in the treatment of male erectile dysfunction indicates the i
Publikováno v:
Neurologia i neurochirurgia polska. 30(1)
Our investigations concerned the blood-brain barrier (b.b.b.) in patients with acute bacterial purulent meningitis. For that purpose concentrations of proteins, which are synthesized beyond the central nervous system and in normal cerebrospinal fluid
Autor:
C D, Brooks, A O, Stewart, A, Basha, P, Bhatia, J D, Ratajczyk, J G, Martin, R A, Craig, T, Kolasa, J B, Bouska, C, Lanni
Publikováno v:
Journal of medicinal chemistry. 38(24)
Structure-activity optimization of inhibitory potency and duration of action of N-hydroxyurea containing 5-lipoxygenase inhibitors was conducted. The lipophilic heteroaryl template and the link group connecting the template to the N-hydroxyurea pharm
Publikováno v:
Neurologia i neurochirurgia polska. 29(5)
CRP level was determined in the cerebrospinal fluid in 40 cases of bacterial meningitis. Similar determination in serum was done in 32 of these patients. Aetiological verification was possible in 90% of cases. Meningitis caused by Str. pneumonia and