Zobrazeno 1 - 10
of 179
pro vyhledávání: '"T Kevin, Hitchens"'
Autor:
Lauren Taylor Rosenblum, ReidAnn E. Sever, Ryan Gilbert, David Guerrero, Sarah R. Vincze, Dominic M. Menendez, Peggy A. Birikorang, Mikayla R. Rodgers, Ambika Parmar Jaswal, Alexander C. Vanover, Joseph D. Latoche, Angel G. Cortez, Kathryn E. Day, Lesley M. Foley, Chaim T. Sneiderman, Itay Raphael, T. Kevin Hitchens, Jessie R. Nedrow, Gary Kohanbash, W. Barry Edwards, Marcus M. Malek
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Surgical resection is integral for the treatment of neuroblastoma, the most common extracranial solid malignancy in children. Safely locating and resecting primary tumor and remote deposits of disease remains a significant challen
Externí odkaz:
https://doaj.org/article/46a524a2699743eba0f0f099fc8cbf76
Autor:
Jonathan C. Ho, Erinn M. Grigsby, Arianna Damiani, Lucy Liang, Josep-Maria Balaguer, Sridula Kallakuri, Lilly W. Tang, Jessica Barrios-Martinez, Vahagn Karapetyan, Daryl Fields, Peter C. Gerszten, T. Kevin Hitchens, Theodora Constantine, Gregory M. Adams, Donald J. Crammond, Marco Capogrosso, Jorge A. Gonzalez-Martinez, Elvira Pirondini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Cerebral white matter lesions prevent cortico-spinal descending inputs from effectively activating spinal motoneurons, leading to loss of motor control. However, in most cases, the damage to cortico-spinal axons is incomplete offering a pote
Externí odkaz:
https://doaj.org/article/d4927e0f83af4c0dbcccba5823b0dc73
Autor:
Sarah R. Vincze, Ambika P. Jaswal, Stephen C. Frederico, Michal Nisnboym, Bo Li, Zujian Xiong, ReidAnn E. Sever, Chaim T. Sneiderman, Mikayla Rodgers, Kathryn E. Day, Joseph D. Latoche, Lesley M. Foley, T. Kevin Hitchens, Robin Frederick, Ravi B. Patel, Costas G. Hadjipanayis, Itay Raphael, Jessie R. Nedrow, W. Barry Edwards, Gary Kohanbash
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor. Currently, there are few effective treatment options for GBM beyond surgery and chemo-radiation, and even with these interventions, median patient survival remains poor. Wh
Externí odkaz:
https://doaj.org/article/fc294d0e99e04fd0a3d770a3246088f3
Autor:
Michel Modo, Katherine Sparling, Jacob Novotny, Nikhita Perry, Lesley M. Foley, T. Kevin Hitchens
Publikováno v:
NeuroImage, Vol 282, Iss , Pp 120406- (2023)
The connectivity of the hippocampus is essential to its functions. To gain a whole system view of intrahippocampal connectivity, ex vivo mesoscale (100 μm isotropic resolution) multi-shell diffusion MRI (11.7T) and tractography were performed on ent
Externí odkaz:
https://doaj.org/article/47195800dec848e5b86e4046ef637a04
Autor:
Shanshan Song, Md Nabiul Hasan, Lauren Yu, Satya S. Paruchuri, John P. Bielanin, Shamseldin Metwally, Helena C. M. Oft, Sydney G. Fischer, Victoria M. Fiesler, Tanusree Sen, Rajaneesh K. Gupta, Lesley M. Foley, T. Kevin Hitchens, C. Edward Dixon, Franca Cambi, Nilkantha Sen, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Differential microglial inflammatory responses play a role in regulation of differentiation and maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is altered by traumatic brain injury (TBI) and its impac
Externí odkaz:
https://doaj.org/article/9a5a38ebd5124d2ba4abf05f52c62bee
Autor:
Hongjian Pu, Yangfan Wang, Tuo Yang, Rehana K. Leak, R. Anne Stetler, Fang Yu, Wenting Zhang, Yejie Shi, Xiaoming Hu, Ke-jie Yin, T. Kevin Hitchens, C. Edward Dixon, Michael V.L. Bennett, Jun Chen
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106078- (2023)
Traumatic brain injury (TBI) is commonly followed by intractable psychiatric disorders and long-term changes in affect, such as anxiety. The present study sought to investigate the effect of repetitive intranasal delivery of interleukin-4 (IL-4) nano
Externí odkaz:
https://doaj.org/article/2cc010faead44f79a9f7f797f81fd883
Autor:
Chunling Yuan, Ligen Shi, Zeyu Sun, Fei Xu, Chujun Wang, Jiajing Shan, T. Kevin Hitchens, Lesley M. Foley, Qing Ye, Jun Chen, Dandan Sun, Xiaoming Hu
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106063- (2023)
Recent research highlights the function of regulatory T cells (Tregs) in white matter integrity in CNS diseases. Approaches that expand the number of Tregs have been utilized to improve stroke recovery. However, it remains unclear if Treg augmentatio
Externí odkaz:
https://doaj.org/article/922a68ebcaf044a1a06d40a16b2bac7b
Autor:
Tetsuichi Saito, T. Kevin Hitchens, Lesley M. Foley, Nishant Singh, Shinsuke Mizoguchi, Masahiro Kurobe, Daisuke Gotoh, Teruyuki Ogawa, Tomonori Minagawa, Osamu Ishizuka, Christopher Chermansky, Jonathan Kaufman, Naoki Yoshimura, Pradeep Tyagi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract To quantify the urinary bladder wall T1 relaxation time (T1) before and after the instillation contrast mixture in rats previously subjected to water avoidance stress (WAS) and/or acute exposure to protamine sulfate (PS). Female Wistar rats
Externí odkaz:
https://doaj.org/article/4760258bb244492d84bb423083d095b7
Autor:
Qian Liu, Mohammad Iqbal H. Bhuiyan, Ruijia Liu, Shanshan Song, Gulnaz Begum, Cullen B. Young, Lesley M. Foley, Fenghua Chen, T. Kevin Hitchens, Guodong Cao, Ansuman Chattopadhyay, Li He, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-21 (2021)
Abstract Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na+/H+ exchanger-1
Externí odkaz:
https://doaj.org/article/0b7b9c35d6e04796b892cecb0d5468ea
Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice
Autor:
Wei Cai, Ligen Shi, Jingyan Zhao, Fei Xu, Connor Dufort, Qing Ye, Tuo Yang, Xuejiao Dai, Junxuan Lyu, Chenghao Jin, Hongjian Pu, Fang Yu, Sulaiman Hassan, Zeyu Sun, Wenting Zhang, T. Kevin Hitchens, Yejie Shi, Angus W. Thomson, Rehana K. Leak, Xiaoming Hu, Jun Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Immunomodulation holds therapeutic promise against brain injuries, but leveraging this approach requires a precise understanding of mechanisms. We report that CD8+CD122+CD49dlo T regulatory-like cells (CD8+ TRLs) are among the earliest lymphocytes to
Externí odkaz:
https://doaj.org/article/6faa48ac6514477ea85a1c9ae8ac6563