Zobrazeno 1 - 10
of 228
pro vyhledávání: '"T Kendall Harden"'
Autor:
Nicole Hajicek, Nicholas C Keith, Edhriz Siraliev-Perez, Brenda RS Temple, Weigang Huang, Qisheng Zhang, T Kendall Harden, John Sondek
Publikováno v:
eLife, Vol 8 (2019)
Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological processes, including chemotaxis, platelet aggregation, and adaptive immunity. In turn, aberrant
Externí odkaz:
https://doaj.org/article/1d56ad94b75749b5a9664ffba654d969
Autor:
David S. Paul, Tasha N. Blatt, Wyatt J. Schug, Emily G. Clark, Tomohiro Kawano, Nigel Mackman, Sebastian Murcia, Kathryn O. Poe, Jean Marie N. Mwiza, T. Kendall Harden, Wolfgang Bergmeier, Robert A. Nicholas
Publikováno v:
Journal of Thrombosis and Haemostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6dc571c9232539e5c6838563096da4
https://doi.org/10.1016/j.jtha.2023.03.013
https://doi.org/10.1016/j.jtha.2023.03.013
Autor:
Lijun Song, Martijn D. P. Risseeuw, Izet Karalic, Matthew O. Barrett, Kyle A. Brown, T. Kendall Harden, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 19, Iss 4, Pp 4313-4325 (2014)
In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties wit
Externí odkaz:
https://doaj.org/article/90bc235eefcf4629b2b6b8d027b90751
Publikováno v:
Journal of Lipid Research, Vol 50, Iss , Pp S243-S248 (2009)
The physiological effects of many extracellular stimuli are initiated through receptor-promoted activation of phospholipase C and inositol lipid signaling pathways. The historical view that phospholipase C-promoted signaling primarily occurs through
Externí odkaz:
https://doaj.org/article/e85c2b7e91f5435a9339d5131fdca0fa
Autor:
Jarod Waybright, John Sondek, Stuart Endo-Streeter, T. Kendall Harden, Qisheng Zhang, Nicole Hajicek, Xiaoyang Wang, Christian Wohlfeld, Weigang Huang, Matthew O. Barrett
Publikováno v:
The Journal of biological chemistry. 293(5)
A diverse group of cell-surface receptors, including many G protein-coupled receptors and receptor tyrosine kinases, activate phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ef464d3df5f4d016a40a4de360038f
https://pubmed.ncbi.nlm.nih.gov/29263090
https://pubmed.ncbi.nlm.nih.gov/29263090
Autor:
Silvia Paoletta, Clarissa D. Weitzer, Vsevolod Katritch, Kenneth A. Jacobson, T. Kendall Harden, Evgeny Kiselev, Qiang Zhao, Kyle A. Brown, Andrew L. Yin, Raymond C. Stevens, Matthew O. Barrett, Eva Hammes
Publikováno v:
ACS Chemical Biology
The P2Y14 receptor (P2Y14R), one of eight P2Y G protein-coupled receptors (GPCR), is involved in inflammatory, endocrine, and hypoxic processes and is an attractive pharmaceutical target. The goal of this research is to develop high-affinity P2Y14R f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b91b3bd614cf3b09eefefc56e61e6f
https://doi.org/10.1021/cb500614p
https://doi.org/10.1021/cb500614p
Publikováno v:
Biochemistry. 52:4810-4819
Multiple extracellular stimuli, such as growth factors and antigens, initiate signaling cascades through tyrosine phosphorylation and activation of phospholipase C-γ (PLC-γ) isozymes. Like most other PLCs, PLC-γ1 is basally autoinhibited by its X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba0874db2dbe1c246250b11ae8c7713
https://doi.org/10.1021/bi400433b
https://doi.org/10.1021/bi400433b
Autor:
John Sondek, Qisheng Zhang, Matthew O. Barrett, T. Kendall Harden, Stephanie N. Hicks, Weigang Huang, Nicole Hajicek
Publikováno v:
Journal of Biological Chemistry. 288:5840-5848
Phospholipase C (PLC) isozymes are important signaling molecules, but few small molecule modulators are available to pharmacologically regulate their function. With the goal of developing a general approach for identification of novel PLC inhibitors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d848ee22740eb6f2b22b3971215b93dd
https://doi.org/10.1074/jbc.m112.422501
https://doi.org/10.1074/jbc.m112.422501
Autor:
Antonella Ciancetta, Leah Birdwell, Anna Junker, Ramachandran Balasubramanian, Kevin Trujillo, Chiara Martiriggiano, Kenneth A. Jacobson, T. Kendall Harden, Evgeny Kiselev, Giorgi Mtchedlidze, Elisa Uliassi, Kyle A. Brown
Publikováno v:
Journal of Medicinal Chemistry
UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y14R antagonist (3, PPTN) using do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2cf0a4089084710e4a04583c35b50b
http://hdl.handle.net/11585/579988
http://hdl.handle.net/11585/579988
