Zobrazeno 1 - 10
of 185
pro vyhledávání: '"T Keith, Blackwell"'
Autor:
Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.
Externí odkaz:
https://doaj.org/article/0b2d369bb38048e0accd70b4ceb4ae16
Autor:
Jin Meng, Ling Fu, Keke Liu, Caiping Tian, Ziyun Wu, Youngeun Jung, Renan B. Ferreira, Kate S. Carroll, T. Keith Blackwell, Jing Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Reversible cysteine oxidative modifications have emerged as important mechanisms that alter protein function. Here the authors globally assess the cysteine reactivity and an array of cysteine oxidative modifications in C. elegans, providing insights
Externí odkaz:
https://doaj.org/article/4eb29991d93a4c36bb272348ea5b3ccc
Autor:
Nikolaos Tataridas-Pallas, Maximillian A Thompson, Alexander Howard, Ian Brown, Marina Ezcurra, Ziyun Wu, Isabel Goncalves Silva, Christopher D Saunter, Timo Kuerten, David Weinkove, T Keith Blackwell, Jennifer M A Tullet
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009358 (2021)
The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense foo
Externí odkaz:
https://doaj.org/article/0bb85b752bff472e9c3efefb74bab50c
Autor:
Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell, Jeremy M. Van Raamsdonk
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-19 (2018)
Abstract Background The mitochondrial unfolded protein response (mitoUPR) is a stress response pathway activated by disruption of proteostasis in the mitochondria. This pathway has been proposed to influence lifespan, with studies suggesting that mit
Externí odkaz:
https://doaj.org/article/3e24ff41be6c49c6bf436862a3ead19b
Autor:
Jorge Iván Castillo-Quan, Michael J. Steinbaugh, Laura Paulette Fernández-Cárdenas, Nancy K. Pohl, Ziyun Wu, Feimei Zhu, Natalie Moroz, Veronica Teixeira, Monet S. Bland, Nicolas J. Lehrbach, Lorenza Moronetti, Magdalena Teufl, T. Keith Blackwell
Publikováno v:
Science advances. 9(1)
Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA), promotes health and longevity. Here, we show that OA benefits Caenorha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac7c045de3aa939844e8477db008f84
https://pubmed.ncbi.nlm.nih.gov/36598980
https://pubmed.ncbi.nlm.nih.gov/36598980
Autor:
Juliane Cruz Campos, Luiz Henrique Marchesi Bozi, Barbara Krum, Luiz Roberto Grassmann Bechara, Nikolas Dresch Ferreira, Gabriel Santos Arini, Rudá Prestes Albuquerque, Annika Traa, Takafumi Ogawa, Alexander M. van der Bliek, Afshin Beheshti, Edward T. Chouchani, Jeremy M. Van Raamsdonk, T. Keith Blackwell, Julio Cesar Batista Ferreira
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(2)
Exercise is a nonpharmacological intervention that improves health during aging and a valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently alters mitochondrial functionality and metabolism. Mitochondrial fission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cace1ea33525fb25929659d0065a6e1c
https://pubmed.ncbi.nlm.nih.gov/36595699
https://pubmed.ncbi.nlm.nih.gov/36595699
Autor:
Collin Yvès Ewald, John M Hourihan, Monet S Bland, Carolin Obieglo, Iskra Katic, Lorenza E Moronetti Mazzeo, Joy Alcedo, T Keith Blackwell, Nancy E Hynes
Publikováno v:
eLife, Vol 6 (2017)
Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, a
Externí odkaz:
https://doaj.org/article/c1ca8a9498f44db89692e81e2c75f37a
Autor:
Jing Yang, T. Keith Blackwell, Renan B. Ferreira, Youngeun Jung, Ling Fu, Ziyun Wu, Jin Meng, Caiping Tian, Keke Liu, Kate S. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Post-translational changes in the redox state of cysteine residues can rapidly and reversibly alter protein functions, thereby modulating biological processes. The nematode C. elegans is an ideal model organism for studying cysteine-mediated redox si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec495804e0cd676c0ae00240764d05f9
https://doaj.org/article/4eb29991d93a4c36bb272348ea5b3ccc
https://doaj.org/article/4eb29991d93a4c36bb272348ea5b3ccc
Autor:
Juliane Cruz Campos, Luiz Henrique Marchesi Bozi, Annika Traa, Alexander M van der Bliek, Jeremy M. Van Raamsdonk, T. Keith Blackwell, Julio Cesar Batista Ferreira
Exercise is a nonpharmacological intervention that improves health during aging, and a valuable tool in the diagnostics of aging-related diseases. In muscle, exercise transiently alters mitochondrial functionality and metabolism. Mitochondrial fissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a7944e46a7f9636fbc263eef13c821
https://doi.org/10.1101/2022.06.20.496837
https://doi.org/10.1101/2022.06.20.496837
Autor:
Jorge Iván Castillo-Quan, Michael J. Steinbaugh, L. Paulette Fernández-Cárdenas, Nancy K. Pohl, Ziyun Wu, Feimei Zhu, Natalie Moroz, Veronica Teixeira, Monet S. Bland, Nicolas J. Lehrbach, Lorenza E. Moronetti Mazzeo, Magdalena Teufl, T. Keith Blackwell
Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty acid (FA), promotes health and longevity. Here we show that OA benefits C. elegan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc24efea0147a96863409f7428d5d0cc
https://doi.org/10.1101/2022.06.15.496302
https://doi.org/10.1101/2022.06.15.496302