Zobrazeno 1 - 10 of 47 pro vyhledávání: '"T K Aliev"'
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Akademický článek
Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines
Autor: V. A. Toporova, V. V. Argentova, T. K. Aliev, A. A. Panina, D. A. Dolgikh, M. P. Kirpichnikov
Publikováno v: Journal of Genetic Engineering and Biotechnology, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for the production of recombinant monoclonal antibodies. Various metabolic engineering
Externí odkaz: https://doaj.org/article/5e688550cea44f9d97a87acd76137fe4
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3
Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris
Autor: D. A. Dolgikh, E. N. Larina, Dmitry Deryabin, Alexey A. Kubanov, T. V. Bobik, A E Karamova, T. K. Aliev, Mikhail P. Kirpichnikov, A. G. Gabibov, A. A. Nikonorov, Ivan V. Smirnov, M. V. Shpilevaya
Publikováno v: Bulletin of Experimental Biology and Medicine. 171:475-479
A method for the analysis of the epitope specificity of auto-reactive antibodies to desmoglein 3 (Dsg3) using competitive ELISA has been developed. It is based on a two-stage solid-phase ELISA with initial “depletion” of auto-reactive antibodies
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d76e05b51621349e42459540f9c8129
https://doi.org/10.1007/s10517-021-05254-9
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4
Monoclonal Antibodies to PRAME Protein Slow the Development of PRAME-Expressing Tumor
Autor: M. V. Larina, N. A. Lyzhko, L. A. Kesaeva, T. K. Aliev, NN Kasatkina, V. A. Misyurin, Mikhail P. Kirpichnikov, A. V. Misyurin, O. N. Solopova, A. A. Turba, Yu. P. Finashutina
Publikováno v: Doklady Biochemistry and Biophysics. 498:199-202
Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cf122ed562a8a5d3569ab71e94a96a6
https://doi.org/10.1134/s1607672921030091
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5
Recombinant Fragment of the Extracellular Domain of Human Desmoglein 3 Fused with the Fc-Fragment of Human IgG1 Selectively Adsorbs Autoreactive Antibodies from the Sera of Pemphigus Patients
Autor: M. V. Shpilevaya, S M Staroverov, A A Kubanov, E. N. Larina, T. V. Bobik, T. K. Aliev, A. G. Gabibov, V S Karasev, O P Bochkova, Mikhail P. Kirpichnikov, A E Karamova, Ivan V. Smirnov, Dmitry Deryabin, D. S. Balabashin
Publikováno v: Doklady Biochemistry and Biophysics. 498:180-183
Using the recombinant second fragment of the extracellular domain (EC2) of human desmoglein type 3 (Dsg3) as an affinity ligand, an immunosorbent was obtained that selectively binds autoreactive antibodies to this domain from the immune sera of patie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7e4a34e66441515558e7d91564a42a0
https://doi.org/10.1134/s1607672921030054
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6
Effects of Fibroblast Growth Factor-2 and Other Microsupplements on the Productivity of IgG- and IgA-Producing Cell Lines
Autor: M. E. Gasparyan, Mikhail P. Kirpichnikov, D. A. Dolgikh, T. K. Aliev, V. V. Argentova
Publikováno v: Applied Biochemistry and Microbiology. 56:902-908
Several serum-free media have been developed and are successfully used at present for the cultivation of various recombinant eukaryotic cell lines. Therapeutic recombinant IgA antibodies have recently been increasingly used along with numerous IgG1 i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e42b713e9cdffcb7e450c2e282c0b13
https://doi.org/10.1134/s0003683820090021
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Development of a Serum-Free Media Based on the Optimal Combination of Recombinant Protein Additives and Hydrolysates of Non-animal Origin to Produce Immunoglobulins
Autor: E. N. Kaliberda, D. S. Balabashin, Mikhail P. Kirpichnikov, Yuliana A. Mokrushina, T. V. Bobik, Ivan V. Smirnov, Dmitry A. Dolgikh, T. K. Aliev
Publikováno v: Applied Biochemistry and Microbiology. 56:595-603
The potential ability to cultivate a recombinant immunoglobulin (IgG1)-producer line in Iscove’s Modified Dulbecco Medium (IMDM) as the base cultivation medium with the introduction of recombinant proteins and hydrolysates of non-animal origin was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a868ec666782fad993846b3f24aae134
https://doi.org/10.1134/s0003683820050038
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8
Generation and Characterization of Human Interferon-beta Neutralizing Humanized Antibody
Autor: D. S. Balabashin, D. A. Dolgikh, A. A. Panina, P. G. Sveshnikov, N. V. Novoseletsky, S. A. Yakimov, V. S. Rybchenko, T. K. Aliev, O. N. Solopova, Mikhail P. Kirpichnikov
Publikováno v: Russian Journal of Bioorganic Chemistry. 46:778-786
Humanization of antibodies for the development of novel therapeutic agents with low immunogenicity remains a topical problem in modern science. In the present work we describe the humanization of murine antibody B16 which binds and neutralizes human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bcc68827f249905714b3ba2182b7c5a
https://doi.org/10.1134/s1068162020050209
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9
Recombinant Bispecific Antibodies to the Human ErbB2 Receptor and Interferon-Beta
Autor: A. A. Panina, V. S. Rybchenko, O. N. Solopova, D. S. Balabashin, S. A. Yakimov, T. K. Aliev, D. A. Dolgikh, P. G. Sveshnikov, M. P. Kirpichnikov
Publikováno v: Acta Naturae. 12:95-104
The development of and research into new therapies that can selectively and effectively destroy tumor cells that overexpress the ErbB2 receptor is apressing task. Recently, research into the use of type I interferons in the treatment of cancer has in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a73be408728343d2a7b8738579d3270a
https://doi.org/10.32607/actanaturae.11156
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10
Development of the Bispecific Antibody in Fab-scFv Format Based on an Antibody to Human Interferon Beta-1 and Antibody to HER2 Receptor
Autor: D. S. Balabashin, V. A. Toporova, P. G. Sveshnikov, T. K. Aliev, A. A. Panina, Mikhail P. Kirpichnikov, V. V. Argentova, O. N. Solopova, V. S. Rybchenko, D. A. Dolgikh, S. A. Yakimov
Publikováno v: Russian Journal of Bioorganic Chemistry. 46:572-581
The development of new therapies for malignant tumors is an urgent task. Currently, the humanized antibody trastuzumab is considered the “gold standard” in the complex treatment of breast tumors with overexpression of HER2, human epidermal growth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e28ceefcc0b9f462a2bfb183be475c5e
https://doi.org/10.1134/s1068162020040159
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