Zobrazeno 1 - 9
of 9
pro vyhledávání: '"T K, Machu"'
Publikováno v:
The FASEB Journal. 9:1454-1462
Molecular cloning of cDNAs coding for ligand-gated ion channel subunits makes it possible to study the pharmacology of recombinant receptors with defined subunit compositions. Many laboratories have used these techniques recently to study actions of
Autor:
T K, Machu, M E, Hamilton, T F, Frye, C L, Shanklin, M C, Harris, H, Sun, T E, Tenner, F S, Soti, W R, Kem
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(3)
The nicotinic receptor drug candidate, 3-(2,4-dimethoxybenzylidene)-anabaseine (also known as GTS-21; DMXBA), its hydroxy metabolites, and some related analogs were evaluated with the two-electrode voltage-clamp technique in mouse 5-hydroxytryptamine
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
The widely used calcium channel antagonist 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester (TMB-8) has been identified as a noncompetitive antagonist (NCA) and open-channel blocker of both muscle- and neuronal-type nicotinic acetylcholine re
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
We examined the effects of several protein kinase C (PKC) inhibitors on the murine 5-hydroxytryptamine3 (5-HT3) receptor to determine whether they acted directly on the receptor. The 5-HT-evoked currents in Xenopus laevis oocytes expressing the recom
Publikováno v:
Alcoholism, clinical and experimental research. 23(1)
The function of the 5-hydroxytryptamine3 (5-HT3) receptor is enhanced by ethanol, but the amino acid residue(s) that confers sensitivity to ethanol remains to be identified. Phosphorylation of the related GABA(A) receptor has been implicated in confe
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(1)
Cytoclean a commercially available detergent, has selective actions on ligand-gated ion channels. Cytoclean (0.0005-0.01% v/v) potentiated 50 microM glycine responses in oocytes expressing alpha-2 glycine receptors by 23 +/- 7% to 342 +/- 43%. Cytocl
Autor:
T K, Machu, R A, Harris
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 271(2)
One subunit of the 5-hydroxytryptamine3 (5-HT3) receptor has been cloned, and expression of cDNA coding for this protein in Xenopus oocytes results in the formation of homomeric ion channels. In the present study, this system was used to define the s
Publikováno v:
Alcohol and alcoholism (Oxford, Oxfordshire). 28(4)
Phosphorylation of pure cytochrome P4502E1 (CYP2E1) was achieved in vitro using Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). The stoichiometry and time-course of phosphor
Publikováno v:
Journal of neurochemistry. 57(2)
The effect of cyclic AMP (cAMP)-dependent protein phosphorylation on gamma-aminobutyric acidA (GABAA) receptor function was examined using isolated brain membrane vesicles (microsacs). Muscimol-stimulated 36Cl- uptake was studied in mouse brain micro