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Akademický článek

Biomarkers of cardiovascular risk across phenotypes of osteoarthritis

Autor: S. A. Provan, S. Rollefstad, E. Ikdahl, A. Mathiessen, I. J. Berg, I. Eeg, I. B. Wilkinson, C. M. McEniery, T. K. Kvien, H. B. Hammer, N. Østerås, I. K. Haugen, A. G. Semb

Publikováno v: BMC Rheumatology, Vol 3, Iss 1, Pp 1-9 (2019)

Abstract Background The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to compare the levels of ar

Externí odkaz: https://doaj.org/article/a2e09d2b88644a6bb198aa0372c3f6a0

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Akademický článek

Secukinumab provides sustained PASDAS-defined remission in psoriatic arthritis and improves health-related quality of life in patients achieving remission: 2-year results from the phase III FUTURE 2 study

Autor: L. C. Coates, D. D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, T. K. Kvien, L. Gossec, V. Strand, L. Rasouliyan, L. Pricop, K. Ding, S. M. Jugl, C. Gaillez, on behalf of the FUTURE 2 study group

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)

Abstract Background Secukinumab has demonstrated sustained improvement in the signs and symptoms of psoriatic arthritis (PsA) over 2 years in the FUTURE 2 study (NCT01752634). This post hoc analysis assessed the ability of secukinumab to achieve Psor

Externí odkaz: https://doaj.org/article/0dd60651da2b4233be2757c232a6e70f

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Fluctuation and change of serum urate levels and flares in gout: results from the NOR-Gout study

Autor: T. Uhlig, L. F. Karoliussen, J. Sexton, T. K. Kvien, E. A. Haavardsholm, F. Perez-Ruiz, H. B. Hammer

Abstract A gout attack may evolve after a purine-rich diet or alcohol and after starting urate-lowering therapy (ULT). The relationships between fluctuation and change in serum urate (SU) with the occurrence of flares were investigated in this study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c073d32f356990a60f8518ab9b78906
http://hdl.handle.net/10852/97909

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OP0176 THE PERSISTENCE OF ANTI-SPIKE ANTIBODIES FOLLOWING TWO SARS-CoV-2 VACCINES IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASES USING IMMUNOSUPPRESSIVE THERAPY, COMPARED TO HEALTHY CONTROLS

Autor: I. Egeland Christensen, I. Jyssum, A. T. Tveter, J. Sexton, T. T. Tran, S. Mjaaland, G. B. Kro, T. K. Kvien, D. Worren, J. Jahnsen, L. A. Munthe, E. Haavardsholm, J. T. Vaage, G. Grodeland, F. Lund-Johansen, K. K. Jørgensen, S. W. Syversen, G. L. Goll, S. Aarrestad Provan

Publikováno v: Annals of the Rheumatic Diseases. 81:116-117

BackgroundLimited data is available regarding long-term effectiveness of SARS-CoV-2 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy. Whether the persistence of vaccine-induced humoral immunity agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c27f5be5eca635a6c6c553dbe8c63234
https://doi.org/10.1136/annrheumdis-2022-eular.2054

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POS0174 PAIN SEVERITY ACROSS HAND OA PHENOTYPES BASED ON A BIOPSYCHOSOCIAL APPROACH

Autor: E. Mulrooney, T. Neogi, H. Solveig Dagfinrud, H. B. Hammer, P. Steen Pettersen, T. K. Kvien, K. Magnusson, I. K. Haugen

Publikováno v: Annals of the Rheumatic Diseases. 81:317-317

BackgroundHand osteoarthritis (OA) pain is heterogeneous and multifactorial, involving biological, psychological and social aspects extending beyond the OA disease process. Different phenotypes may differ in prognosis and treatments requirements, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::314addc3e2f3e1110841e547613800a5
https://doi.org/10.1136/annrheumdis-2022-eular.537

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POS0281 FLUCTUATIONS IN SERUM URATE ARE RELATED TO GOUT FLARES IN THE NOR-Gout STUDY

Autor: T. Uhlig, L. Karoliussen, J. Sexton, T. K. Kvien, E. A. Haavardsholm, F. Perez-Ruiz, H. B. Hammer

Publikováno v: Annals of the Rheumatic Diseases. 81:384.1-385

BackgroundUrate lowering therapy (ULT) is expected to prevent new gout flares, but flares still do occur during the first year, and could be related to fluctuations in serum urate (SUA), being a result of proinflammatory signals. Knowledge on the rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::746e0d8d2f48ec26becf8f994dc96ecf
https://doi.org/10.1136/annrheumdis-2022-eular.1135

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POS0007 HLA-DQ2 IS ASSOCIATED WITH ANTI-DRUG ANTIBODY FORMATION TO INFLIXIMAB ACROSS IMMUNE-MEDIATED INFLAMMATORY DISEASES

Autor: M. K. Brun, K. H. Bjørlykke, M. K. Viken, B. Stenvik, R. A. Klaasen, J. Gehin, D. J. Warren, J. Sexton, Ø. Sandanger, C. Mørk, T. K. Kvien, E. A. Haavardsholm, J. Jahnsen, G. L. Goll, B. A. Lie, K. K. Jørgensen, N. Bolstad, S. W. Syversen

Publikováno v: Annals of the Rheumatic Diseases. 81:216.2-217

BackgroundImmunogenicity is a leading cause of treatment failure to TNF inhibitors, and also affects drug safety. Variations in HLA class II genes have been suggested to predispose to anti-drug antibody formation (ADA), but characterisation of biolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8fbdc3fa93a62d8cf10b85c30383228
https://doi.org/10.1136/annrheumdis-2022-eular.5020

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OP0192 SEROLOGICAL RESPONSE AND SAFETY OF A THREE-DOSE SARS-CoV-2 VACCINATION STRATEGY IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASES ON IMMUNOSUPPRESSIVE THERAPY

Publikováno v: Annals of the Rheumatic Diseases. 81:127.1-128

BackgroundPatients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy have an inadequate serologic response following two-dose SARS-CoV-2 vaccination, and a standard vaccination strategy of three doses for this patient gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e4685e941b749bd57aafa06cbb68608
https://doi.org/10.1136/annrheumdis-2022-eular.1230

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OP09 Proactive Therapeutic Drug Monitoring is superior to standard treatment during maintenance therapy with infliximab; results from a 52-week multicentre randomised trial of 450 patients; the NOR-DRUM B study

Autor: K K Jørgensen, S W Syversen, G L Goll, K H Bjørlykke, Ø Sandanger, J Sexton, M K Brun, G Noraberg, C M Ystrøm, K A Seeberg, I M Blomgren, R Torp, C Mørk, T K Kvien, N Bolstad, E A Haavardsholm, J Jahnsen

Publikováno v: Journal of Crohn's and Colitis. 16:i010-i010

Background Proactive therapeutic drug monitoring (TDM), individualized treatment based on scheduled assessments of serum drug levels, has been proposed to optimize efficacy and safety of infliximab and other biologic drugs. However, it is unclear whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dca2b0ab458eff7502c3c1a97841be6
https://doi.org/10.1093/ecco-jcc/jjab232.008

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