Zobrazeno 1 - 10
of 18
pro vyhledávání: '"T K, Hart"'
Autor:
T. K. Hart, W. D. Kerns, C. J. Fish, C. M. Johnson, C. C. Gowan, L. M. Posobiec, H. M. Solomon, P. J. Wier, B. E. Maleeff
Publikováno v:
Teratology. 55:185-194
Alterations of the cardiac membranous ventricular septum were studied using macrodissection, scanning electron and light microscopy of fetal, weanling, and adult Sprague-Dawley rats. Membranous ventricular septal defects (VSDs) were observed in 2.0%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d736ba377b4a5681c3b8f73ff66b4c67
https://doi.org/10.1002/(sici)1096-9926(199703)55:3<185::aid-tera3>3.0.co
https://doi.org/10.1002/(sici)1096-9926(199703)55:3<185::aid-tera3>3.0.co
Autor:
P J Vance, Beth S. Haggarty, Celia C. LaBranche, T K Hart, M M Sauter, P J Bugelski, J Romano, Mark Marsh, James A. Hoxie
Publikováno v:
Journal of Virology. 69:5217-5227
We have described a virus termed CP-MAC, derived from the BK28 molecular clone of simian immunodeficiency virus, that was remarkable for its ability to infect Sup-T1 cells with rapid kinetics, cell fusion, and CD4 down-modulation (C. C. LaBranche, M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6953150cad9394d3e27c21446bae0c7d
https://doi.org/10.1128/jvi.69.9.5217-5227.1995
https://doi.org/10.1128/jvi.69.9.5217-5227.1995
Publikováno v:
Humanexperimental toxicology. 21(9-10)
Keliximab is a human-cynomolgus monkey chimeric (Primatized) monoclonal antibody with specificity for human and chimpanzee CD4. As the preclinical safety assessment of biopharmaceuticals requires evaluation in pharmacologically responsive species, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952e24828245d9f43fdc9cd821aec404
https://pubmed.ncbi.nlm.nih.gov/12458908
https://pubmed.ncbi.nlm.nih.gov/12458908
Autor:
T W, Hepburn, T K, Hart, V L, Horton, T S, Sellers, L P, Tobia, J J, Urbanski, W, Shi, C B, Davis
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(3)
The pharmacokinetics and tissue distribution of SB-251353, a novel truncated form of the human CXC chemokine growth-related gene product beta, were studied after intravenous administration to the mouse (0.1--250 mg/kg). At the lowest dose, the cleara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4262e59d1daff7fd725328190d74f86
https://pubmed.ncbi.nlm.nih.gov/11504781
https://pubmed.ncbi.nlm.nih.gov/11504781
Autor:
N A Gillett, K Hastings, J L Bussiere, A Dayan, J A Cavagnaro, U Liminga, P Bouchard, T K Hart, J Rener, T Inoue, D Latta, D M Essayan, P T Thomas, R V House, G Treacy, D Wierda, L E Black, J D Green, P Spindler
Publikováno v:
Humanexperimental toxicology. 19(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3af19a6fadeb9336094b03a971f1b1
https://pubmed.ncbi.nlm.nih.gov/10918508
https://pubmed.ncbi.nlm.nih.gov/10918508
Autor:
P J Bugelski, D M Williams, T K Hart, Danuta J. Herzyk, S Rehm, Richard A. Macia, Allen G. Harmsen, A. Truneh, D G Morgan, E V Gore, A M Badger, B E Maleeff, Patrick J. Wier, S R O'Brien
Publikováno v:
Humanexperimental toxicology. 19(4)
The preclinical safety assessment of biopharmaceuticals necessitates that studies be conducted in species in which the products are pharmacologically active. Monoclonal anti-bodies are a promising class ofbiopharmaceuticals for many disease indicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90da81dcf18ff3742a8a0ebf5ef0b14
https://pubmed.ncbi.nlm.nih.gov/10918514
https://pubmed.ncbi.nlm.nih.gov/10918514
Autor:
P, Zia-Amirhosseini, E, Minthorn, L J, Benincosa, T K, Hart, C S, Hottenstein, L A, Tobia, C B, Davis
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(3)
The pharmacokinetics (PK) of SB-240563 have been investigated after i.v. and s.c. administration to cynomolgus monkeys. Approximately linear PK was observed following i.v. administration over a 6000-fold dose range (0.05-300 mg/kg). After i.v. dosing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a163252683d5c103bfd16a829d1d0c1f
https://pubmed.ncbi.nlm.nih.gov/10565825
https://pubmed.ncbi.nlm.nih.gov/10565825
Autor:
T L, Yue, J, Ni, A M, Romanic, J L, Gu, P, Keller, C, Wang, S, Kumar, G L, Yu, T K, Hart, X, Wang, Z, Xia, W E, DeWolf, G Z, Feuerstein
Publikováno v:
The Journal of biological chemistry. 274(3)
TL1 is a recently discovered novel member of the tumor necrosis factor (TNF) cytokine family. TL1 is abundantly expressed in endothelial cells, but its function is not known. The present study was undertaken to explore whether TL1 induces apoptosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0278ad7949796551c8ed78453e2d8414
https://pubmed.ncbi.nlm.nih.gov/9880523
https://pubmed.ncbi.nlm.nih.gov/9880523
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783540659273
Respiratory syncytial virus (RSV) is a major and highly contagious respiratory pathogen that most people are exposed to within the first year or two of life. It is the dominant cause of severe lower respiratory-tract disease (bronchiolitis and pneumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f1c41336af1a6fd523439d704dd652
https://doi.org/10.1007/978-3-642-59990-3_6
https://doi.org/10.1007/978-3-642-59990-3_6
Autor:
H M, Solomon, P J, Wier, C J, Fish, T K, Hart, C M, Johnson, L M, Posobiec, C C, Gowan, B E, Maleeff, W D, Kerns
Publikováno v:
Teratology. 55(3)
Alterations of the cardiac membranous ventricular septum were studied using macrodissection, scanning electron and light microscopy of fetal, weanling, and adult Sprague-Dawley rats. Membranous ventricular septal defects (VSDs) were observed in 2.0%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c791eae85c8b22be381611634e38e01b
https://pubmed.ncbi.nlm.nih.gov/9181672
https://pubmed.ncbi.nlm.nih.gov/9181672