Zobrazeno 1 - 10
of 166
pro vyhledávání: '"T K, Das Gupta"'
Autor:
Jon M. Richards, T. K. Das Gupta, L Rae Bressler, D. Mehta, Scott Kennedy, Taketo Yamada, Dibyen Majumdar, Craig W. Beattie, Michael A. Warso, Konstantin Christov, C. M. Schaeffer
Publikováno v:
British Journal of Cancer
Background: This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tolerability, pharmacokinetics and preliminary activity of p28 in patients with p53+ metastatic so
Publikováno v:
Acta Pathologica Microbiologica Scandinavica Section A Pathology. :203-207
The innervation of ileal mucosa of normal, unanaesthetized male Wistar rats was investigated electronmicroscopically. The presence of RBC inside intestinocytes was a secondary, but frequent observation in 4 of 20 rats. No sign of hemorrhage or trauma
Autor:
A W Chow, A. W. Boddie, RB van Breemen, Rajendra G. Mehta, Chongwoo Yu, John M. Pezzuto, T. K. Das Gupta, Genoveva Murillo
Publikováno v:
European Journal of Cancer Prevention. 14:351-356
Rhabdomysarcoma is the most common soft tissue tumour in children under the age of 15. Although the introduction of multimodal treatment programmes, including chemotherapy, radiation therapy and excision have increased the overall survival, the chemo
Autor:
Masatoshi Goto, John H. Horner, Tohru Yamada, Kazuhide Kimbara, A. M. Chakrabarty, Martin Newcomb, T. K. Das Gupta
Publikováno v:
Molecular Microbiology. 47:549-559
Azurin is a copper-containing protein involved in electron transfer during denitrification. We reported recently that purified azurin demonstrates cytotoxicity to macrophages by forming a complex with the tumour-suppressor protein p53, thereby stabil
Autor:
Anissa Agadir, Robert M. Moriarty, M Poria, Xiao-kun Zhang, W Qing, T. K. Das Gupta, Gianluca Lazzaro, Rajendra G. Mehta, Rajeshwari R. Mehta
Publikováno v:
European Journal of Cancer. 36:780-786
The role of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), in cell differentiation is well established. However, its use as a differentiating agent in a clinical setting is precluded due to its hypercalcaemic activi
Autor:
Ludwine Messiaen, Rogier Versteeg, I. Bar-Am, J.M. Naeyaert, M.L. Geerts, Franki Speleman, Salve G. Ronan, Elisabeth Blennow, J H Leonard, M. Van Gele, J Vandesompele, P van der Drift, T. K. Das Gupta, N. Van Roy
Publikováno v:
Genes, chromosomes & cancer, 23(1), 67-71. Wiley-Liss Inc.
Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin. Only little information is available on the genetic alterations occurring in this tumor. Cytogenetic studies thus far have not shown recurrent chromosomal changes, alt
Autor:
T J Hieken, Rajeshwari R. Mehta, Minu Patel, Linda Wild, K C Marler, T. K. Das Gupta, J H McDermott
Publikováno v:
Journal of Clinical Oncology. 16:2409-2416
PURPOSE To determine the significance of plasma c-erbB-2 levels to assess the extent of disease spread and to predict the response to chemotherapy in node-positive breast cancer patients. METHODS We determined plasma levels of c-erbB-2 in 79 stages I
Publikováno v:
British Journal of Cancer
Xenografts originated from human tumours offer the most appropriate research material for in vivo experimental research. However, primary human breast carcinomas are difficult to grow when transplanted in athymic mice: tumour take is less than 15%. R
Autor:
Holzmayer Tatyana, Edward A. Levine, R Mera, T. K. Das Gupta, C Bolliger, E Mechetner, S Bacus, Igor B. Roninson
Publikováno v:
Scopus-Elsevier
PURPOSE In addition to tumor size, grade, location, and the presence of metastases, other factors may be useful in prognostication for adults with soft tissue sarcoma (STS). This study examines the relationship of MDR-1 mRNA, p-glycoprotein (P-gp), K
Publikováno v:
British Journal of Cancer
We established a panel of 17 xenografts from primary human breast carcinomas. We examined which characteristics of the original tumours and the xenografts facilitate growth in animals. Tumours expressing medium or strong immunoreactivity for p53 prot