Zobrazeno 1 - 10
of 17
pro vyhledávání: '"T K, Blackwell"'
Publikováno v:
Oncogene. 19:1657-1664
The immediate early protein tristetraprolin (TTP) is required to prevent inappropriate production of the cytokine TNF-alpha, and is a member of a zinc finger protein family that is associated with RNA binding. TTP expression is induced by TNF-alpha,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e45f9fb07f71d3a10644dc23db63362
https://doi.org/10.1038/sj.onc.1203474
https://doi.org/10.1038/sj.onc.1203474
Publikováno v:
International Immunology. 3:751-760
The immunoglobulin light chain V kappa 1 gene family is polymorphic in murine inbred strains and this family has been subdivided into five sub-groups (V kappa 1A-E). The V kappa 1A sub-group contributes to approximately 2% of the total serum immunogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4c30f05c047d760d8092b60904f77c
https://doi.org/10.1093/intimm/3.8.751
https://doi.org/10.1093/intimm/3.8.751
Autor:
Heikyung Suh, Pierre Ferrier, T K Blackwell, Frederick W. Alt, Barbara A. Malynn, Lori R. Covey, Shaoguang Li, Maureen A. Morrow
Publikováno v:
The Journal of Experimental Medicine
To further analyze the VDJ recombination defect in lymphoid pre-B cells from mice with severe combined immune deficiency (scid mice), we have assayed the ability of Abelson murine leukemia virus (A-MuLV) transformed pre-B cells from scid mice to rear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e5cca1fe73a3b56b41321e7ba018c1
https://doi.org/10.1084/jem.171.6.1909
https://doi.org/10.1084/jem.171.6.1909
Autor:
F. Costantini, Wendy D. Cook, Pierre Ferrier, B. Krippl, Andrew J.W. Furley, Heikyung Suh, Frederick W. Alt, T K Blackwell, Astar Winoto, L. Hood
Publikováno v:
Europe PubMed Central
We describe transgenic mice that carry an antigen receptor gene minilocus comprised of germline T cell receptor (TCR) beta variable gene elements (V, D and J) linked to an immunoglobulin (Ig) C mu constant region gene with or without a DNA segment co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbff7328e629c10959cd372240a2f2e
https://doi.org/10.1002/j.1460-2075.1990.tb08087.x
https://doi.org/10.1002/j.1460-2075.1990.tb08087.x
Autor:
T. K. Blackwell
Basic-helix-loop-helix (bHLH) transcription factor proteins are involved in cell growth and differentiation, and the bHLH protein c-Myc has been implicated in breast cancer. We have determined that the sequence preference and specificity with which p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aedfbc4a8249a65e3a30c83918173df
https://doi.org/10.21236/ada371161
https://doi.org/10.21236/ada371161
Autor:
T K, Blackwell
Publikováno v:
Methods in enzymology. 254
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03031e673b36165d2f8ea2fdc7a774e0
https://pubmed.ncbi.nlm.nih.gov/8531718
https://pubmed.ncbi.nlm.nih.gov/8531718
Autor:
Erik Selsing, Mark W. Moore, T K Blackwell, George D. Yancopoulos, Frederick W. Alt, Heikyung Suh, Stuart Lutzker
Publikováno v:
Nature. 324:585-589
Immunoglobulin (Ig) variable (V) region genes are assembled in precursor B (pre-B) lymphocytes from multiple germline segments. The heavy-chain V-region gene is composed of variable (VH), diversity (D) and joining (JH) segments; kappa (K) and lambda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8bc2e10aa25d789ec17da7de4edc07
https://doi.org/10.1038/324585a0
https://doi.org/10.1038/324585a0
Publikováno v:
Science. 238:1079-1087
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139a6b9e4719a68fbbed460a83038e98
https://doi.org/10.1126/science.3317825
https://doi.org/10.1126/science.3317825
Autor:
Pierre Ferrier, Lori R. Covey, George D. Yancopoulos, G. M. Fulop, Roberta R. Pollock, Frederick W. Alt, Robert A. Phillips, T K Blackwell, Barbara A. Malynn
Publikováno v:
The EMBO Journal. 8:735-742
Consistent with an ordered immunoglobulin (Ig) gene assembly process during precursor (pre-) B cell differentiation, we find that most Abelson murine leukemia virus (A-MuLV)-transformed pre-B cells derived from scid (severe combined immune deficient)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4ea3b99fed18f10a3eb9a00e8a9e87
https://doi.org/10.1002/j.1460-2075.1989.tb03433.x
https://doi.org/10.1002/j.1460-2075.1989.tb03433.x
Autor:
Frederick W. Alt, T K Blackwell
Publikováno v:
Annual Review of Genetics. 23:605-636
Both variable region gene assembly and HC class switching seem to be regulated processes. The mechanisms that control these events appear to be intimately related to the progression of B-lymphocyte differentiation. In this review we describe current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff215bde43b382ac0a80a7624447086b
https://doi.org/10.1146/annurev.ge.23.120189.003133
https://doi.org/10.1146/annurev.ge.23.120189.003133