Zobrazeno 1 - 10
of 44
pro vyhledávání: '"T Jakubik"'
Autor:
Dejan Juric, Jeffrey A. Engelman, Cyril H. Benes, Hiromichi Ebi, Aditya Bardia, Leif W. Ellisen, Nicholas J. Dyson, James R. Stone, Mari Mino-Kenudson, Christopher J. Pinto, Ioannis Sanidas, Daria Timonina, Leah J. Damon, Laura E. Henderson, Charles T. Jakubik, Shogo Yanase, Rachel Peterson, Christopher Healy, Tiffany Huynh, Charlotte S. Walmsley, Ellen Murchie, Yasuyuki Hosono, Amy Ly, Ye Wang, Carlotta Costa
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b723650133405abfb9014d897936b55
https://doi.org/10.1158/2159-8290.22529202
https://doi.org/10.1158/2159-8290.22529202
Autor:
Charles T. Jakubik, Claire C. Weckerly, Gerald R.V. Hammond, Anne R. Bresnick, Jonathan M. Backer
Publikováno v:
FEBS Lett
PI3Kβ is required for invadopodia-mediated matrix degradation by breast cancer cells. Invadopodia maturation requires GPCR activation of PI3Kβ and its coupling to SHIP2 to produce PI(3,4)P(2). We now test whether selectivity for PI3Kβ is preserved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b996939d39e27dac7cd209a47d9a74
https://doi.org/10.1002/1873-3468.14273
https://doi.org/10.1002/1873-3468.14273
Autor:
Sheeba Jacob, Tia H Turner, Jinyang Cai, Konstantinos V Floros, Ann K Yu, Colin M Coon, Rishabh Khatri, Mohammad A Alzubi, Charles T Jakubik, Ynes M Bouck, Madhavi Puchalapalli, Mayuri Shende, Mikhail G Dozmorov, Sosipatros A Boikos, Bin Hu, J Chuck Harrell, Cyril H Benes, Jennifer E Koblinski, Carlotta Costa, Anthony C Faber
Publikováno v:
PNAS Nexus. 1
Triple negative breast cancer (TNBC) accounts for over 30% of all breast cancer (BC)-related deaths, despite accounting for only 10% to 15% of total BC cases. Targeted therapy development has largely stalled in TNBC, underlined by a lack of tradition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ebdd1723650544a3719525301f2b58c
https://doi.org/10.1093/pnasnexus/pgac232
https://doi.org/10.1093/pnasnexus/pgac232
Autor:
Sheeba Jacob, Tia H. Turner, Jinyang Cai, Konstantinos V. Floros, Ann K. Yu, Colin M. Coon, Rishabh Khatri, Mohammad A. Alzubi, Charles T. Jakubik, Ynes M. Bouck, Madhavi Puchalapalli, Mayuri Shende, Mikhail G. Dozmorov, Sosipatros A. Boikos, Bin Hu, J. Chuck Harrell, Cyril H. Benes, Jennifer E. Koblinski, Carlotta Costa, Anthony C. Faber
Triple negative breast cancer (TNBC) accounts for over 30% of all breast cancer-related deaths, despite accounting for only 10%–15% of total breast cancer cases. Targeted therapy development has largely stalled in TNBC, underlined by a lack of trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::168504c73550089d39cd6033d0f5ee36
https://doi.org/10.1101/2022.05.17.491908
https://doi.org/10.1101/2022.05.17.491908
Autor:
Mohammad A. Alzubi, Carlotta Costa, Sosipatros A. Boikos, Tia H. Turner, Sheeba Jacob, Cyril H. Benes, Ynes M Bouck, Joshua C. Harrell, Anthony C. Faber, Charles T. Jakubik, Ann K. Yu, Colin M. Coon, Mikhail G. Dozmorov, Jennifer E. Koblinski
Publikováno v:
Cancer Research. 80:P1-19
Triple negative breast cancer (TNBC) confers the poorest prognosis of the major subtypes of breast cancers, and often inflicts young, African-American and Hispanic women. Steadily improving survival in other subsets of breast cancers are attributed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3bd7d19d26014672bacbd51154580f4
https://doi.org/10.1158/1538-7445.sabcs19-p1-19-28
https://doi.org/10.1158/1538-7445.sabcs19-p1-19-28
Autor:
Gilbert Salloum, Zahra Erami, Jonathan M. Backer, Samantha D. Heitz, Charles T. Jakubik, Anne R. Bresnick
Publikováno v:
J Cell Sci
Macropinocytosis is an actin-dependent but clathrin-independent endocytic process by which cells nonselectively take up large aliquots of extracellular material. Macropinocytosis is used for immune surveillance by dendritic cells, as a route of infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b335fdead6d538c4c0cfa879b40f9c7
https://doi.org/10.1242/jcs.231639
https://doi.org/10.1242/jcs.231639
Autor:
Charles T. Jakubik, Ultan McDermott, Neha U. Patel, Carlotta Costa, Anahita Dastur, Justin T. Ferrell, Aaron N. Hata, Kateryna Krytska, Timothy L. Lochmann, Mikhail G. Dozmorov, Shirley M. Taylor, Ryan J. March, Molly L. Bristol, Konstantinos V. Floros, Jungoh Ham, Wataru Nakajima, Erin M. Sennott, Anthony C. Faber, Mathew J. Garnett, Renata Sano, Mark T. Hughes, Daniel A. R. Heisey, Iain M. Morgan, Jeffrey A. Engelman, Cyril H. Benes, Maria Gomez-Caraballo, Brad Windle, Yael P. Mosse, Hisashi Harada, Craig Yates, Madhu Gowda, Mark A. Hicks
Publikováno v:
Cancer Cell
Summary Fewer than half of children with high-risk neuroblastoma survive. Many of these tumors harbor high-level amplification of MYCN, which correlates with poor disease outcome. Using data from our large drug screen we predicted, and subsequently d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee17cc301bd05410146adb2e97177c3d
https://doi.org/10.1016/j.ccell.2016.01.002
https://doi.org/10.1016/j.ccell.2016.01.002
Autor:
Christopher J. Pinto, Carlotta Costa, Charles T. Jakubik, Leah J. Damon, Daria Timonina, Cyril H. Benes, Yasuyuki Hosono, Nicholas J. Dyson, Rachel Peterson, Leif W. Ellisen, Amy Ly, Hiromichi Ebi, Ioannis Sanidas, Jeffrey A. Engelman, Tiffany Huynh, James R. Stone, Christopher Healy, Ye Wang, Mari Mino-Kenudson, Ellen Murchie, Dejan Juric, Shogo Yanase, Aditya Bardia, L. Henderson, Charlotte S. Walmsley
Publikováno v:
Cancer Research. 80:1903-1903
The combination of CDK4/6 inhibitors with anti-estrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3906aadafbc0a893298169fcc1313cd
https://doi.org/10.1158/1538-7445.am2020-1903
https://doi.org/10.1158/1538-7445.am2020-1903
Autor:
Yasuyuki Hosono, Christopher Healy, Christopher J. Pinto, Carlotta Costa, Ioannis Sanidas, Ye Wang, Rachel Peterson, Leah J. Damon, Jeffrey A. Engelman, Daria Timonina, James R. Stone, Aditya Bardia, Hiromichi Ebi, Tiffany Huynh, Amy Ly, Charlotte S. Walmsley, Nicholas J. Dyson, Mari Mino-Kenudson, Charles T. Jakubik, Dejan Juric, Ellen Murchie, L. Henderson, Shogo Yanase, Cyril H. Benes, Leif W. Ellisen
Publikováno v:
Cancer discovery. 10(1)
The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617d3962449b68467c84acd4ffdac644
https://pubmed.ncbi.nlm.nih.gov/31594766
https://pubmed.ncbi.nlm.nih.gov/31594766
Autor:
Carlotta Costa, Charles T. Jakubik, Cyril H. Benes, Ye Wang, Wilhelm Haas, Jeffrey A. Engelman, Rachel Peterson
Publikováno v:
Cancer Research. 78:5502-5502
Endometrial cancer is the most common gynecologic malignancy in the developed world. These cancers harbor the highest rates of PI3K pathway alterations reported, with PTEN being the most frequently altered gene. Differently from other cancer types, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::392175f0d8110ff610c8a90885c0dedf
https://doi.org/10.1158/1538-7445.am2018-5502
https://doi.org/10.1158/1538-7445.am2018-5502