Zobrazeno 1 - 10
of 525
pro vyhledávání: '"T Jake, Liang"'
Autor:
Seung Bum Park, Mohsin Khan, Sai Chaitanya Chiliveri, Xin Hu, Parker Irvin, Madeleine Leek, Ailis Grieshaber, Zongyi Hu, Eun Sun Jang, Ad Bax, T. Jake Liang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Since the emergence of the Omicron variants at the end of 2021, they quickly became the dominant variants globally. The Omicron variants may be more easily transmitted compared to the earlier Wuhan and the other variants. In this study, we a
Externí odkaz:
https://doaj.org/article/91540e85d7364d0480d15dc87697cdce
Publikováno v:
Viruses, Vol 16, Iss 4, p 528 (2024)
The post-transcriptional regulatory element (PRE) is present in all HBV mRNAs and plays a major role in their stability, nuclear export, and enhancement of viral gene expression. Understanding PRE’s structure, function, and mode of action is essent
Externí odkaz:
https://doaj.org/article/3dacf905a66041d0bf911ac306039d3e
Autor:
Takeshi Chida, Yuji Ishida, Sho Morioka, Go Sugahara, Christine Han, Bill Lam, Chihiro Yamasaki, Remi Sugahara, Meng Li, Yasuhito Tanaka, T. Jake Liang, Chise Tateno, Takeshi Saito
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Hepatitis delta virus (HDV), a satellite virus of HBV, is regarded as the most severe type of hepatitis virus because of the substantial morbidity and mortality. The IFN system is the first line of defense against viral infections and an essential el
Externí odkaz:
https://doaj.org/article/608b3b9284e2485ab23afc6503eddeab
Autor:
Seung Bum Park, Takuro Uchida, Samantha Tilson, Zongyi Hu, Christopher D. Ma, Madeleine Leek, Michael Eichner, So Gun Hong, T. Jake Liang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 656-669 (2022)
The CRISPR-Cas9 system has emerged as a powerful and efficient tool for genome editing. An important drawback of the CRISPR-Cas9 system is the constitutive endonuclease activity when Cas9 endonuclease and its sgRNA are co-expressed. This constitutive
Externí odkaz:
https://doaj.org/article/00a6b3d2302c442a9d0074954e895b9b
Autor:
Takuro Uchida, Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn N. Allen, Kazuaki Chayama, T. Jake Liang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 597-605 (2021)
The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression. The NTCP-S267F variant displays diminished function in medi
Externí odkaz:
https://doaj.org/article/6da94754d7634c86bd34d99931061100
Autor:
Naveen Gara, Michele M. Tana, Meera Kattapuram, Sungyoung Auh, Lauren Sullivan, Nancy Fryzek, Mary Walter, Regina Umarova, Xiongce Zhao, Gavin Cloherty, Edward Doo, Theo Heller, T. Jake Liang, Marc G. Ghany
Publikováno v:
Hepatology Communications, Vol 5, Iss 11, Pp 1888-1900 (2021)
Nucleoside analogue (NA) therapy for chronic hepatitis B (CHB) is associated with improved clinical outcomes, but usually requires long‐term use. Whether treatment can be safely withdrawn and the factors associated with post‐withdrawal outcome ar
Externí odkaz:
https://doaj.org/article/1aa19527091a4b5298d59a09cd9fcedb
Publikováno v:
Viruses, Vol 15, Iss 7, p 1530 (2023)
Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication. Thi
Externí odkaz:
https://doaj.org/article/c45bb62675864f52a52f1788309bb231
Autor:
Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao
Publikováno v:
Journal of the Formosan Medical Association, Vol 119, Iss 9, Pp 1382-1395 (2020)
Background: Patients with different hepatitis C virus (HCV) genotype infections are associated with varying metabolic disorders. Although alteration of lipid metabolism has been confirmed as a virus-induced metabolic derangement in chronic hepatitis
Externí odkaz:
https://doaj.org/article/7664b93fea174a54ac172da0de9634da
Autor:
Seung Bum Park, Parker Irvin, Zongyi Hu, Mohsin Khan, Xin Hu, Qiru Zeng, Catherine Chen, Miao Xu, Madeleine Leek, Ruochen Zang, James Brett Case, Wei Zheng, Siyuan Ding, T. Jake Liang
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a serious threat to global public health, underscoring the urgency of developing effective therapies. Therapeutics and, m
Externí odkaz:
https://doaj.org/article/515b14c4834f43dcb95a0c60017d099a
Autor:
Jaime Guardia
Publikováno v:
New England Journal of Medicine. 343:1899-1900
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc958a85ea623701b1259893c71c92e5
https://doi.org/10.1056/nejm200012213432517
https://doi.org/10.1056/nejm200012213432517