Výsledky vyhledávání

A monoclonal antibody discriminating between subsets of T and B cells

Autor: J Bruce, F W Symington, T J McKearn, J Sprent

Publikováno v: The Journal of Immunology. 127:2496-2501

A description is given of a rat anti-mouse hybridoma antibody, JIId, which reacts with erythrocytes, neutrophils, greater than 90% of thymus cells, and most B cells. JIId does not have detectable activity for mature T cells, pluripotential stem cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36c5a51852a07ced7f5cc6569a1598ac
https://doi.org/10.4049/jimmunol.127.6.2496

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Class I major histocompatibility gene products of the brown Norway rat display two major antigenic regions

Autor: D M Klinman, D E Smilek, T J McKearn

Publikováno v: The Journal of Immunology. 129:1204-1208

Sixteen Lewis anti-Brown Norway monoclonal antibodies and sera from alloimmunized Lewis rats were used to study the topographic relationships of antigenic determinants on class I major histocompatibility gene products. Only two independent antigenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcc76dd475261578579a8c08e923d2e9
https://doi.org/10.4049/jimmunol.129.3.1204

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Anti-Idiotypic Antibody in Rat Transplantation Immunity

Autor: T. J. McKearn, F. P. Stuart, F. W. Fitch

Publikováno v: The Journal of Immunology. 113:1876-1882

Lewis × Brown Norway (LBN) F1 antiserum to an idiotype of Lewis anti-BN alloantibody (referred to as the Id-1 idiotype) was used to test a variety of Lewis alloimmune sera for the presence of Id-1. Several such Lewis sera raised by BN antigen inject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dde2f72fdeb8a1a23fd9c6c6bde9971
https://doi.org/10.4049/jimmunol.113.6.1876

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Inhibition of mannosidase in hybridomas yields monoclonal antibodies with greater capacity for carbohydrate labeling

Autor: Cynthia Long, R W Gillette, T J McKearn, R B Simonson, J D Rodwell, M E Ultee

Publikováno v: Clinical Chemistry. 34:1713-1716

Labeling an antibody site specifically through its carbohydrate residues preserves more of its antigen-binding activity than does labeling through protein moieties. To boost the amount of immunoglobulin G carbohydrate capable of being labeled, we tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d55a4f14ff6ed66b01d7b0b4b87fdfd
https://doi.org/10.1093/clinchem/34.9.1709

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Immunohistochemical application of monoclonal antibodies against myelin basic protein and neurofilament triple protein subunits: advantages over antisera and technical limitations

Autor: William F. Hickey, Nicholas K. Gonatas, Virginia M.-Y. Lee, John Q. Trojanowski, T. J. McKearn, L. J. McMillan, Jacqueline O. Gonatas

Publikováno v: Journal of Histochemistry & Cytochemistry. 31:1126-1135

Four monoclonal antibodies against guinea pig myelin basic protein (MBP), and four against subunits of bovine neurofilament triplet proteins (NF) were produced and their activity determined by enzyme-linked immunosorbant assay. The specificity and cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c4cbd89c77bdb30d6ce7f24b13ddf4
https://doi.org/10.1177/31.9.6193166

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Monoclonal antibody directed to a B-cell antigen present in rats, mice, and humans

Autor: D L Gasser, T J McKearn, R H Kennett, B A Winters, J B Haas

Publikováno v: Proceedings of the National Academy of Sciences. 76:4636-4640

Spleen cells from a LEW.AVN rat immunized with cells from an MNR rat were fused with mouse myeloma cells to produce hybrid cell lines. One of these hybridomas produced a monoclonal antibody that was cytotoxic for bone marrow-derived (B) but not thymu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb39ecc32c74124e19b6ba23230ffeef
https://doi.org/10.1073/pnas.76.9.4636

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