Zobrazeno 1 - 7
of 7
pro vyhledávání: '"T J Goletz"'
Autor:
Sabina Buntich, Amber Umble-Romero, Wei-Jian Pan, L Som, Jason M. Gow, C D Krill, Yu Sun, Samantha P. Prokop, Kathleen Köck, Alexander Colbert, Yu Zhang, Wayne Tsuji, Jennifer E. Towne, T J Goletz, M W Trimble, William A. Rees, John P. Gibbs, Michelle Horner, J C O'Neill, Kathryn J. Newhall
Publikováno v:
British Journal of Pharmacology. 172:159-172
Background and Purpose AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2df1ca4f60b9725b1651875f7c7b2d
https://doi.org/10.1111/bph.12904
https://doi.org/10.1111/bph.12904
Autor:
K, Köck, W J, Pan, J M, Gow, M J, Horner, J P, Gibbs, A, Colbert, T J, Goletz, K J, Newhall, W A, Rees, Y, Sun, Y, Zhang, J C, O'Neill, A N, Umble-Romero, S P, Prokop, C D, Krill, L, Som, S A, Buntich, M W, Trimble, W H, Tsuji, J E, Towne
Publikováno v:
British journal of pharmacology. 172(1)
AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to determine the pharmacology,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d0f52f37c3b39236e9095f107f806db
https://pubmed.ncbi.nlm.nih.gov/25205227
https://pubmed.ncbi.nlm.nih.gov/25205227
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology. 59:59-66
Cellular senescence is an inability of cells to synthesize DNA and divide, which results in a terminal loss of proliferation despite the maintenance of basic metabolic processes. Senescence has been proposed as a model for the study of aging at the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df404f749c1ba39d959017918f1ebfc6
https://doi.org/10.1101/sqb.1994.059.01.009
https://doi.org/10.1101/sqb.1994.059.01.009
Autor:
B S, Worley, L T, van den Broeke, T J, Goletz, C D, Pendleton, E M, Daschbach, E K, Thomas, F M, Marincola, L J, Helman, J A, Berzofsky
Publikováno v:
Cancer research. 61(18)
Synovial sarcoma (SS), clear cell sarcoma (CCS), and desmoplastic small round cell tumor (DSRCT) are soft-tissue malignancies occurring primarily in adolescents and young adults. These tumors contain specific chromosomal translocations that fuse the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8889b05038a5565436c2bae03420d180
https://pubmed.ncbi.nlm.nih.gov/11559563
https://pubmed.ncbi.nlm.nih.gov/11559563
Autor:
E Y, Woo, C S, Chu, T J, Goletz, K, Schlienger, H, Yeh, G, Coukos, S C, Rubin, L R, Kaiser, C H, June
Publikováno v:
Cancer research. 61(12)
Immunosuppression may contribute to the progression of cancer. In this study we assessed the structural and functional status of T cells from tumor specimens obtained from patients with early stage non-small cell lung cancer and late-stage ovarian ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db4b4025a13d77e0eea851c59a4154c7
https://pubmed.ncbi.nlm.nih.gov/11406550
https://pubmed.ncbi.nlm.nih.gov/11406550
Autor:
J F, McDyer, M, Dybul, T J, Goletz, A L, Kinter, E K, Thomas, J A, Berzofsky, A S, Fauci, R A, Seder
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(6)
The role of exogenous stimulation of CD40 by CD40 ligand (CD40L) in dendritic cell (DC) maturation, CC-chemokine production, and CCR5 receptor expression was examined using a soluble trimeric CD40L agonist protein (CD40LT). Stimulation of monocyte-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7520a0c0c1874d01a5d76f839615da1
https://pubmed.ncbi.nlm.nih.gov/10092834
https://pubmed.ncbi.nlm.nih.gov/10092834
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(4)
CD40 ligand (CD40L)/CD40 costimulation is an important regulator of Th1 responses. Two mechanisms by which CD40L/CD40 stimulation may enhance IFN-gamma are via direct induction of IL-12 and augmentation of the expression of costimulatory molecules su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d3990a01dbd9703f3bb995877f1b2db
https://pubmed.ncbi.nlm.nih.gov/9469427
https://pubmed.ncbi.nlm.nih.gov/9469427