Výsledky vyhledávání

Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta

Autor: R, Cazzolli, D L, Craig, T J, Biden, C, Schmitz-Peiffer

Publikováno v: American journal of physiology. Endocrinology and metabolism. 282(6)

We have previously shown that glycogen synthesis is reduced in lipid-treated C(2)C(12) skeletal muscle myotubes and that this is independent of changes in glucose uptake. Here, we tested whether mitochondrial metabolism of these lipids is necessary f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::528999794ba8dff6e279fb47a18a67ca
https://pubmed.ncbi.nlm.nih.gov/12006349

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Regulation by membrane potential of phosphatidylinositol hydrolysis in pancreatic islets

Autor: T J, Biden, A G, Davison, M L, Prugue

Publikováno v: The Journal of biological chemistry. 268(15)

In pancreatic islets stimulated with carbamylcholine (carbachol), hydrolysis of both phosphatidylinositol (PtdIns) and phosphatidylinositol bisphosphate (Ptd-InsP2) occurs and can be measured as the inositol monophosphates Ins(1)P1, or Ins(4)P1, resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48cb4675d8ebfde296eb97532f8df472
https://pubmed.ncbi.nlm.nih.gov/8496168

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Effects of glucose and d-3-hydroxybutyrate on human pancreatic islet cell function

Autor: P. D. Reynolds, T J Biden, C. J. Rhodes, T. M. Szopa, I. L. Campbell, O. N. Fernando, K. W. Taylor

Publikováno v: Clinical Science. 68:567-572

1. β-Cell function in human islets derived from a number of kidney donors was investigated by using various types of islet preparations. 2. With fresh islets, both insulin release and biosynthesis were increased by raising glucose concentrations, al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f1d7679a8a40d7ad86ec71bbafa118
https://doi.org/10.1042/cs0680567

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Effects of ketone bodies on insulin release and islet-cell metabolism in the rat

Autor: K. W. Taylor, T J Biden

Publikováno v: Biochemical Journal. 212:371-377

Ketone bodies promote insulin secretion from isolated rat pancreatic islets in the presence of 5 mM-glucose, but are ineffective in its absence. At concentrations of 10 mM or less, the relative abilities of the ketone bodies to potentiate release are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d58fa5113197c185c4e11c6f1532d70
https://doi.org/10.1042/bj2120371

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The role of cytosolic free calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL-60 cells. Differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels

Autor: Francis Waldvogel, P D Lew, T J Biden, Werner Schlegel, Karl-Heinz Krause, Antoinette Monod

Publikováno v: Journal of Biological Chemistry, Vol. 261, No 28 (1986) pp. 13121-13127

The generation of the two inositol trisphosphate (IP3) isomers, 1,4,5-IP3 and 1,3,4-IP3, and its relation to changes in the cytosolic free calcium concentration, [Ca2+]i, in response to the chemotactic peptide fMet-Leu-Phe was studied in the human pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fd5ad3726c162141837c2b5baef8b2
https://doi.org/10.1016/s0021-9258(18)69279-8

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Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells

Autor: T J Biden, Claes B. Wollheim, Jos A. Cox, Michelle Comte

Publikováno v: Journal of Biological Chemistry. 262:9437-9440

In a cytosolic fraction derived from insulin-secreting RINm5F cells, the rate of conversion of inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) to inositol 1,3,4,5-tetrakisphosphate (Ins-1,3,4,5-P4) was half-maximally stimulated by 0.8 microM Ca2+ (Biden,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d301f061e47d4867b39e06b41ca2803
https://doi.org/10.1016/s0021-9258(18)47951-3

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Signal Transduction in Insulin Secretion

Autor: Claes B. Wollheim, T J Biden

Publikováno v: Annals of the New York Academy of Sciences. 488:317-333

The initial events in signal transduction in insulin-secreting cells are summarized in FIGURE 8. Both nutrient stimuli, such as glucose and amino acids and the muscarinic agonist carbachol (carbamylcholine) raise [Ca2+]i. Although the rise in [Ca2+]i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811f3170e2513f2c3273483993a92f7a
https://doi.org/10.1111/j.1749-6632.1986.tb54414.x

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Rapid increases in inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate and cytosolic free Ca2+ in agonist-stimulated pancreatic acini of the rat. Effect of carbachol, caerulein and secretin

Autor: R Bruzzone, T J Biden, C J Meehan, E R Trimble

Publikováno v: ResearcherID

We compared the time course of increases in isomers of inositol trisphosphate [Ins(1,4,5)P3] and Ins(1,3,4)P3] and the tetrakisphosphate [Ins(1,3,4,5)P4] with changes in cytosolic free Ca2+ [(Ca2+]i) in dispersed pancreatic acini of the rat. There we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb575c14e6f649fa0deb9319a201d57
https://doi.org/10.1042/bj2420289

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Active transport of myo-inositol in rat pancreatic islets

Autor: Claes B. Wollheim, T J Biden

Publikováno v: Biochemical Journal. 236:889-893

myo-Inositol transport by isolated pancreatic islets was measured with a dual isotope technique. Uptake was saturable with a half-maximal response at approx. 75 microM. With 50 microM-inositol, uptake was linear for at least 2 h during which time the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce3a2bb915fdab78aab9aa566359e2a
https://doi.org/10.1042/bj2360889

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