Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma

Autor: Liam G Heaney, T. J. Warke, Peter Bradding, Richard Carter, Grzegorz Skibinski, Cliff Taggart, Stephen McQuaid, Sinéad Weldon, David F. Choy, Joe Arron, Lorcan McGarvey, Claire A. Butler

Publikováno v: Thorax. 67:392-398

Rationale Upregulation of glucocorticoid receptor β (GRβ) has been implicated in steroid resistance in severe asthma, although previous studies are conflicting. GRβ has been proposed as a dominant negative isoform of glucocorticoid receptor α (GR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574fef45230fb6736c1097aacf84387d
https://doi.org/10.1136/thoraxjnl-2011-200760

Non-bronchoscopic sampling and culture of bronchial epithelial cells in children

Autor: Liam G Heaney, Michael D. Shields, Sarah M. Puddicombe, F. De Courcey, Madeleine Ennis, Grzegorz Skibinski, Gary M. Doherty, T. J. Warke, A. L. Cross, Jeremy Lyons, S. N. Christie

Publikováno v: Clinical & Experimental Allergy. 33:1221-1225

Background The bronchial epithelium is likely to play a vital role in airway diseases in children, such as asthma and viral-associated wheeze. In adults, studies with primary bronchial epithelial cells cultured from samples obtained by fibre-optic br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::598088ba10d1cf13545115bef0defe20
https://doi.org/10.1046/j.1365-2222.2003.01752.x

Exhaled nitric oxide correlates with airway eosinophils in childhood asthma

Autor: Jeremy Lyons, Madeleine Ennis, P.S. Fitch, T. J. Warke, Vanessa Brown, Michael D. Shields, R. Taylor

Publikováno v: Warke, T, Fitch, P S, Brown, V, Taylor, R, Lyons, J D, Ennis, M & Shields, M 2002, ' Exhaled nitric oxide correlates with airway eosinophils in childhood asthma ' Thorax, vol. 57, no. 5, pp. 383-387 . DOI: 10.1136/thorax.57.5.383

Background: Exhaled nitric oxide has been proposed as a marker for airway inflammation in asthma. The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d7d72a67b3da9133e7472130da9f06
https://doi.org/10.1136/thorax.57.5.383

Psychogenic cough in a schoolboy: Evaluation using an ambulatory cough recorder

Autor: T. J. Warke, Lorcan McGarvey, Cathal McNiff, Liam G Heaney, Joseph MacMahon

Publikováno v: Pediatric Pulmonology. 36:73-75

Psychogenic cough occurs most commonly in patients under 18 years of age. Making the diagnosis on clinical features alone is problematic, and it is usually a diagnosis of exclusion after several negative clinical investigations. We report on the case

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2ad51de802decbdbfcb50bed3972af
https://doi.org/10.1002/ppul.10291

The Sensory Receptor TRPV1 Is Expressed In Human Bronchial Epithelium And Upregulated In Refractory (Steroid Resistant) Asthma

Autor: Liam G Heaney, T. J. Warke, Stephen McQuaid, Michael Stevenson, Lorcan McGarvey, Claire A. Butler

Publikováno v: B13. MECHANISMS OF EPITHELIAL CELL DYSFUNCTION IN AIRWAY DISEASE.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd4698cd12917e0a99d52c42545efea7
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2490