Zobrazeno 1 - 10 of 45 pro vyhledávání: '"T J, Tewson"'
1
Studies with [11C]alprazolam: an agonist for the benzodiazepine receptor
Autor: Joseph C. Fleishaker, William R. Banks, Alan D. Valentine, George A. Digenis, T. J. Tewson, Frank R. Dobbs, Mark P. Franceschini, Berma M. Kinsey
Publikováno v: Nuclear Medicine and Biology. 22:459-466
We have built a system for the synthesis of high specific activity carbon-11 alprazolam (Xanax), a high affinity agonist for the benzodiazepine receptor. The system produces 30-40 mCi of the compound with a specific activity of > 12,000 Ci per millim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dd9a416c8c20f006a6d8a87ca7e94f
https://doi.org/10.1016/0969-8051(94)00131-3
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2
Temporal analysis of myocardial glucose metabolism by 2-[18F]fluoro-2-deoxy-D-glucose
Autor: W. H. Wong, R. W. Rowe, V. T.B. Nguyen, G. M. Coleman, K. A. Mossberg, T. J. Tewson, Heinrich Taegtmeyer
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 259:H1022-H1031
To assess kinetic changes of myocardial glucose metabolism after physiological interventions, we perfused isolated working rat hearts with glucose and 2-[18F]fluoro-2-deoxy-D-glucose (2-FDG). Tissue uptake of 2-FDG and the input function were measure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc078420a736d63988b7e0c63db6a45a
https://doi.org/10.1152/ajpheart.1990.259.4.h1022
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3
[18F]fluoroestradiol radiation dosimetry in human PET studies
Autor: D A, Mankoff, L M, Peterson, T J, Tewson, J M, Link, J R, Gralow, M M, Graham, K A, Krohn
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 42(4)
[18F]16alpha-fluoroestradiol (FES) is a PET imaging agent useful for the study of estrogen receptors in breast cancer. We estimated the radiation dosimetry for this tracer using data obtained in patient studies.Time-dependent tissue concentrations of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b38cb80076f4e74e9f1623ae6a48f512
https://pubmed.ncbi.nlm.nih.gov/11337559
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5
Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia
Autor: J S, Rasey, P D, Hofstrand, L K, Chin, T J, Tewson
Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(6)
Fluorinated derivatives of etanidazole are being explored as probes for tumor hypoxia. Our research group has synthesized [18F]fluoroetanidazole (FETA) and now reports the oxygen dependency of binding to cells in vitro, the biodistribution of the tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f9d3f0d8504f4d567f8b8d3a766c07d1
https://pubmed.ncbi.nlm.nih.gov/10452326
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6
The synthesis of fluorine-18 lomefloxacin and its preliminary use in human studies
Autor: Robert J. Nickles, Michael R. Taylor, S.B. Perlman, David J. Yang, O.J. DeJesus, P. Frank, D. Macy, G. Wong, T. J. Tewson
Publikováno v: Nuclear medicine and biology. 23(6)
Lomefloxacin is a new fluorine-containing antibiotic that has recently been approved for general use. Fluorine-18 lomefloxacin has been prepared by fluoride exchange between fluorine-18 fluoride and lomefloxacin in DMSO. Both time and temperature of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53216b77b2dd901de91342dd35b4bd8
https://pubmed.ncbi.nlm.nih.gov/8940719
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9
Halogenated analogues of tamoxifen: synthesis, receptor assay, and inhibition of MCF7 cells
Autor: Kevin Chu, Li-Ren Kuang, Wayne Tansey, Roy S. Tilbury, Kenneth C. Wright, Gregg Reger, T. J. Tewson, Abdallah Cherif, David J. Yang, E. Edmund Kim, Sidney Wallace, R. Gene Moult
Publikováno v: Journal of pharmaceutical sciences. 81(7)
This study was conducted to develop a ligand for imaging estrogen-receptor-positive breast tumors by positron emission tomography or single photon emission computed tomography. We synthesized fluoro and iodo analogues of tamoxifen, and these halogena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc829bd361e66dd4528c38c1f2e93eb
https://pubmed.ncbi.nlm.nih.gov/1403692
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10
Fluorine-18 Ligands for the in Vivo Study of the Beta Adrenergic Receptor in the Heart and Lung
Autor: T. J. Tewson, R. Barber, B. M. Kinsey
Publikováno v: New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control ISBN: 9781489906281
In the last 10 years there has been considerable interest in development of receptor ligands labeled with externally detectable radionuclides for the study of receptors in vivo. Most of the interest has been directed towards compounds labeled with po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b93fc1e562fc3fe5f985647552194aa
https://doi.org/10.1007/978-1-4899-0626-7_11
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