Zobrazeno 1 - 10 of 41 pro vyhledávání: '"T J, Monks"'
3
Quinol-glutathione conjugate-induced mutation spectra in the supF gene replicated in human AD293 cells and bacterial MBL50 cells
Autor: J K, Jeong, G N, Wogan, S S, Lau, T J, Monks
Publikováno v: Cancer research. 59(15)
Hydroquinone is a nephrocarcinogen in rats but generally tests negative in standard mutagenicity assays. However, 2,3,5-tris-(glutathion-S-yl)hydroquinone, a potent nephrotoxic metabolite of hydroquinone, and 2-bromo-bis-(glutathion-S-yl)hydroquinone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38b3ccd915a4df39a2fd3e1a80806ebe
https://pubmed.ncbi.nlm.nih.gov/10446975
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4
Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells
Autor: J K, Jeong, J L, Stevens, S S, Lau, T J, Monks
Publikováno v: Molecular pharmacology. 50(3)
Although the conjugation of quinones with glutathione is associated with the process of detoxication, the reaction frequently facilitates quinone-induced toxicity. Thiol conjugates of quinones retain the ability to redox cycle and generate reactive o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8cff6f411b9085808f0ef664f93e5733
https://pubmed.ncbi.nlm.nih.gov/8794898
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5
17 beta-Estradiol metabolism by hamster hepatic microsomes. Implications for the catechol-O-methyl transferase-mediated detoxication of catechol estrogens
Autor: M, Butterworth, S S, Lau, T J, Monks
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(5)
We have shown that the metabolism of 17 beta-estradiol in hamster liver microsomes is concentration-dependent. At low (25 microM) concentrations of 17 beta-estriol, 16 alpha-hydroxylase activity predominated, and estriol was the major metabolite. At
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95d2fe6bc407db513b2378c4e4d9bcae
https://pubmed.ncbi.nlm.nih.gov/8723741
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6
Glutathione conjugates of tert-butyl-hydroquinone, a metabolite of the urinary tract tumor promoter 3-tert-butyl-hydroxyanisole, are toxic to kidney and bladder
Autor: M M, Peters, M I, Rivera, T W, Jones, T J, Monks, S S, Lau
Publikováno v: Cancer research. 56(5)
3-tert-Butyl-4-hydroxyanisole and tert-butyl-hydroquinone (TBHQ) are antioxidants known to promote renal and bladder carcinogenesis in the rat, although the mechanisms of these effects are unclear. Because glutathione (GSH) conjugates of a variety of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19280e17b7f35871d07c35dbd9cb8625
https://pubmed.ncbi.nlm.nih.gov/8640754
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9
Metabolism as a determinant of species susceptibility to 2,3,5-(triglutathion-S-yl)hydroquinone-mediated nephrotoxicity. The role of N-acetylation and N-deacetylation
Autor: S S, Lau, H E, Kleiner, T J, Monks
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(10)
2,3,5-(Triglutathion-S-yl)hydroquinone [2,3,5-(triGSyl)HQ] is a potent nephrotoxicant when administered to male rats. We now report that significant species differences exist in susceptibility to 2,3,5-(triGSyl)HQ-mediated nephrotoxicity. Metabolism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3af13090067a1fdebb4e0d8b0fa70de
https://pubmed.ncbi.nlm.nih.gov/8654203
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10
Metabolism and toxicity of 2-bromo-(diglutathion-S-yl)-hydroquinone and 2-bromo-3-(glutathion-S-yl)hydroquinone in the in situ perfused rat kidney
Autor: M I, Rivera, L M, Hinojosa, B A, Hill, S S, Lau, T J, Monks
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 22(4)
2-Br-(diglutathion-S-yl)hydroquinone (2-Br-(diGSyl)HQ) is a potent nephrotoxicant, causing glucosuria, enzymuria, proteinuria, elevations in blood urea nitrogen, and severe histological alterations to renal proximal tubules at doses of 10-15 mumol/kg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20e2e3cf51754e7d8b782135f8f7a670
https://pubmed.ncbi.nlm.nih.gov/7956722
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