Zobrazeno 1 - 10
of 32
pro vyhledávání: '"T J, Ley"'
Autor:
J W, Heusel, E M, Scarpati, N A, Jenkins, D J, Gilbert, N G, Copeland, S D, Shapiro, T J, Ley
Publikováno v:
Blood. 81:1614-1623
We previously have characterized a cluster of genes encoding cathepsin G (CG) and two other CG-like hematopoietic serine proteases, CGL-1 and CGL-2, on human chromosome 14. In this report, we clone and characterize a novel, related murine hematopoiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc74f286231756e6e49ffb0e1363924
https://doi.org/10.1182/blood.v81.6.1614.bloodjournal8161614
https://doi.org/10.1182/blood.v81.6.1614.bloodjournal8161614
Autor:
R D, Hanson, T J, Ley
Publikováno v:
Blood. 79:610-618
We have analyzed approximately 70 kb of the chromosome 14q11.2 hematopoietic serine protease gene cluster for the presence of nuclear scaffold attachment regions (SARs). At least 12 potential attachment sites were identified. SARs are present on both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeafc5a2b3a8dc45eb4722b03e00dbf8
https://doi.org/10.1182/blood.v79.3.610.bloodjournal793610
https://doi.org/10.1182/blood.v79.3.610.bloodjournal793610
Publikováno v:
Blood. 77:2272-2284
In this report, we compare the function of the human beta-globin locus control region (LCR) in three K562 erythroleukemia cell assays, including (1) a transient transfection assay for “classical' enhancer activity, (2) a colony assay that detects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac56277ac31bb555da7f110bd020c140
https://doi.org/10.1182/blood.v77.10.2272.bloodjournal77102272
https://doi.org/10.1182/blood.v77.10.2272.bloodjournal77102272
A Novel c-fgr Exon Utilized in Epstein-Barr Virus-Infected B Lymphocytes but Not in Normal Monocytes
Publikováno v:
Molecular and Cellular Biology. 11:1500-1507
The fgr proto-oncogene encodes a nonreceptor protein-tyrosine kinase, designated p55c-fgr. In this study, we have isolated human fgr cDNA molecules from normal monocyte mRNA templates. Nucleotide sequence analysis of the longest fgr cDNA revealed a 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a101b63073f4ece08b3a3ec691e0f911
https://doi.org/10.1128/mcb.11.3.1500-1507.1991
https://doi.org/10.1128/mcb.11.3.1500-1507.1991
Publikováno v:
Blood. 95(11)
Mammalian beta-globin loci are composed of multiple orthologous genes whose expression is erythroid specific and developmentally regulated. The expression of these genes both from the endogenous locus and from transgenes is strongly influenced by a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2676dbb25cee5d985add4fddbb6ccc4e
https://pubmed.ncbi.nlm.nih.gov/10828050
https://pubmed.ncbi.nlm.nih.gov/10828050
Publikováno v:
Blood. 94(12)
Cathepsin G is a neutral serine protease that is highly expressed at the promyelocyte stage of myeloid development. We have developed a homologous recombination strategy to create a loss-of-function mutation for murine cathepsin G. Bone marrow derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::377d2b0bb5c6d02547d234aff518597b
https://pubmed.ncbi.nlm.nih.gov/10590073
https://pubmed.ncbi.nlm.nih.gov/10590073
Publikováno v:
Blood. 94(9)
To date, the normal transcriptional regulation of the human beta-globin gene cluster has been recapitulated most accurately in transgenic mice that carry large yeast artificial chromosome (YAC) or ligated cosmid constructs. However, these large trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9f5dfa7e0d9fa3d0cdce373806c581b
https://pubmed.ncbi.nlm.nih.gov/10556205
https://pubmed.ncbi.nlm.nih.gov/10556205
Publikováno v:
Blood. 93(3)
Human granzyme H is a neutral serine protease that is expressed predominantly in the lymphokine-activated killer (LAK)/natural killer (NK) compartment of the immune system. The gene that encodes this granzyme is located between the granzyme B and cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17c282e6166d619dc5725bc89c86f772
https://pubmed.ncbi.nlm.nih.gov/9920846
https://pubmed.ncbi.nlm.nih.gov/9920846
Publikováno v:
Blood. 89(11)
Using granzyme B-deficient mice obtained by gene targeting, we previously demonstrated that granzyme B is required for the rapid induction of apoptotic target cell death by cytotoxic T lymphocytes (CTLs); however, CTLs are also equipped with addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c333f2772b974b5fff422b848fd9e7a7
https://pubmed.ncbi.nlm.nih.gov/9166849
https://pubmed.ncbi.nlm.nih.gov/9166849
Publikováno v:
Blood. 89(2)
Acute promyelocytic leukemia (APML) is characterized by abnormal myeloid development, resulting an accumulation of leukemic promyelocytes that are often highly sensitive to retinoic acid. A balanced t(15;17) (q22;q21) reciprocal chromosomal transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71f89de42d5611de6abbf86399997be7
https://pubmed.ncbi.nlm.nih.gov/9002938
https://pubmed.ncbi.nlm.nih.gov/9002938