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A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector

Autor: T J Gonda, J R Rayner

Publikováno v: Molecular and Cellular Biology. 14:880-887

cDNA expression cloning is a powerful method for the rescue and identification of genes that are able to confer a readily identifiable phenotype on specific cell types. Retroviral vectors provide several advantages over DNA-mediated gene transfer for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173963d9ace5fc79312b81462dddef61
https://doi.org/10.1128/mcb.14.2.880

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Differentiation state and responses to hematopoietic growth factors of murine myeloid cells transformed by myb

Autor: T J, Gonda, E M, Macmillan, P V, Townsend, A J, Hapel

Publikováno v: Blood. 82:2813-2822

Murine hematopoietic cells can be transformed in vitro by recombinant retroviruses that express the myb oncogene, and hematopoietic growth factor (HGF)-dependent myeloid cell lines can be derived from these transformed primary cells. In this study, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4848185494ba0d2732f85deda64e3904
https://doi.org/10.1182/blood.v82.9.2813.bloodjournal8292813

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Interaction of the Myb protein with specific DNA binding sites

Autor: Robert G. Ramsay, Shunsuke Ishii, T J Gonda

Publikováno v: Scopus-Elsevier

c-myb is expressed predominantly in proliferating immature hemopoietic cells and, like v-myb, functions as a transcriptional activator that displays sequence-specific DNA binding. Oncogenic activation of the c-myb protein (Myb) is associated with car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ca547e7c0bb102c51ec0372167c60e
https://doi.org/10.1016/s0021-9258(18)42816-5

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Na+/H+ exchange involvement in colony-stimulating factor-1-stimulated macrophage proliferation. Evidence for a requirement during late G1 of the cell cycle but not for early growth factor responses

Autor: John A. Hamilton, T J Gonda, Gino Vairo, E J Cragoe, A M Bordun, S Argyriou

Publikováno v: Scopus-Elsevier

Na+/H+ exchange activation by growth factors is proposed to be an important early signal for mitogenesis; however, little is known of its duration and requirement during later stages of the cell cycle. Macrophage-specific colony factor (CSF-1) rapidl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3553024c43ffcfaed7526f646ccf9
https://doi.org/10.1016/s0021-9258(17)44850-2

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Mutation screening of the c-MYB negative regulatory domain in acute and chronic myeloid leukaemia

Autor: J K, Lutwyche, R A, Keough, T P, Hughes, T J, Gonda

Publikováno v: British journal of haematology. 114(3)

Over-expression of the c-myb gene and expression of activated forms of myb are known to transform haemopoietic cells, particularly cells of the myeloid lineage. Truncations or mutations that disrupt the negative regulatory domain (NRD) of the Myb pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c4293e1445968aef11607e483dacc64
https://pubmed.ncbi.nlm.nih.gov/11552989

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A model for assembly and activation of the GM-CSF, IL-3 and IL-5 receptors: insights from activated mutants of the common beta subunit

Autor: R J, D'Andrea, T J, Gonda

Publikováno v: Experimental hematology. 28(3)

Granulocyte-macrophage colony stimulating factor (GM-CSF), Interleukin-3 (IL-3) and Interleukin-5 (IL-5) have overlapping, pleiotropic effects on hematopoietic cells, including neutrophils, eosinophils, monocytes and early progenitor cells. The high-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04d9eecdf1f0106372bce20274cac9a8
https://pubmed.ncbi.nlm.nih.gov/10720688

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Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor beta subunit

Autor: M P, McCormack, T J, Gonda

Publikováno v: Blood. 95(1)

Several activating mutations have recently been described in the common beta subunit for the human interleukin(IL)-3, IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors (hbetac). Two of these, FIDelta and I374N, result, res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7cd1b51602b957962907821116dcfb6
https://pubmed.ncbi.nlm.nih.gov/10607694

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Saturation mutagenesis of the beta subunit of the human granulocyte-macrophage colony-stimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential beta subunit tyrosine phosphorylation

Autor: B J, Jenkins, T J, Blake, T J, Gonda

Publikováno v: Blood. 92(6)

The high-affinity receptors for human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 are heterodimeric complexes consisting of cytokine-specific alpha subunits and a common signal-transducing beta subunit (h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e11b11fd880154c64cca506525624020
https://pubmed.ncbi.nlm.nih.gov/9731057

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Expression of constitutively activated human c-Kit in Myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity

Autor: P, Ferrao, T J, Gonda, L K, Ashman

Publikováno v: Blood. 90(11)

The cDNAs encoding wild type (WT) human receptor tyrosine kinase c-Kit and a constitutively activated mutant, V816Kit, were introduced into granulocyte-macrophage colony-stimulating factor (GM-CSF )-dependent early murine hemopoietic cells, which had

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ffd35440480a83ae737cafdf129a5ae
https://pubmed.ncbi.nlm.nih.gov/9373265

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Expression of activated mutants of the human interleukin-3/interleukin-5/granulocyte-macrophage colony-stimulating factor receptor common beta subunit in primary hematopoietic cells induces factor-independent proliferation and differentiation

Autor: M P, McCormack, T J, Gonda

Publikováno v: Blood. 90(4)

To date, several activating mutations have been discovered in the common signal-transducing subunit (h(beta)c) of the receptors for human granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Two of these, FIdelta and I3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7564960b9a8f3a81cb67f42b0776b9a
https://pubmed.ncbi.nlm.nih.gov/9269764

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