Výsledky vyhledávání - "T J, Franklin"

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Biochemistry and Molecular Biology of Antimicrobial Drug Action

Autor: T. J. Franklin, G. A. Snow

The rapid advances made in the study of the synthesis, structure and function of biological macromole cules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of

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Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analog N-oxaloglycine and its derivatives

Autor: N. J. Hales, T. J. Franklin, C. J. Cunliffe, G. B. Hill

Publikováno v: Journal of Medicinal Chemistry. 35:2652-2658

N-Oxaloglycine (3) is an alpha-ketoglutarate (1) analogue that is a competitive inhibitor of prolyl 4-hydroxylase (EC 1.14.11.2). A study of the structure-activity relationships of some other oxalo derivatives shows that substitution on the glycine m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917c4aae631c48946cb15da38dc16978
https://doi.org/10.1021/jm00092a016

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A novel series of non-nucleoside inhibitors of inosine 5'-monophosphate dehydrogenase with immunosuppressive activity

Autor: T J, Franklin, W P, Morris, V N, Jacobs, E J, Culbert, C A, Heys, W H, Ward, P N, Cook, F, Jung, P, Plé

Publikováno v: Biochemical pharmacology. 58(5)

Inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) are effective immunosuppressive drugs that may also have additional potential applications as antitumour and antimicrobial agents. The clinical value of the most potent and sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8168368f7052fe92db61adcbd9480500
https://pubmed.ncbi.nlm.nih.gov/10449198

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Biochemical mechanisms of resistance to antimicrobial drugs

Autor: G. A. Snow, T. J. Franklin

Publikováno v: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9780412821905
Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9781475746013

Although the individual modes of resistance to antimicrobial drugs are very diverse, they can be grouped into a limited set of general mechanisms that account for most types of resistance encountered in medical practice. These include: 1. conversion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58759d58beeaed275aa28103d0bc68dd
https://doi.org/10.1007/978-94-010-9127-5_9

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The genetic basis of resistance to antimicrobial drugs

Autor: T. J. Franklin, G. A. Snow

Publikováno v: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9781475746013
Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9780412821905

The development of safe, effective antimicrobial drugs has revolutionized medicine in the past 60 years. Morbidity and mortality from microbial disease have been drastically reduced by modern chemotherapy. Unfortunately, micro-organisms are nothing i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee546b298932fa345e3f6b4080d9a9b
https://doi.org/10.1007/978-1-4757-4599-3_8

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Antimicrobial drugs with other modes of action

Autor: G. A. Snow, T. J. Franklin

Publikováno v: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9780412821905
Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9781475746013

The antimicrobial agents described so far have been arranged together according to their primary effects on cellular metabolism and biosynthesis. This approach accounts for many of the most important drugs in current antimicrobial therapy. There are,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d280e0c583f3f27e9d724bce45f28a8
https://doi.org/10.1007/978-94-010-9127-5_6

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Vulnerable shields — the cell walls of bacteria and fungi

Autor: T. J. Franklin, G. A. Snow

Publikováno v: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9780412821905
Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9781475746013

In the search for differences between microbial pathogens and animal cells that could provide the basis for selective antimicrobial attack, one evident distinction lies in their general structure. The animal cell is relatively large and has a complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02cf7355c296d82e44f2699422b4173
https://doi.org/10.1007/978-94-010-9127-5_2

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The development of antimicrobial agents past, present and future

Autor: T. J. Franklin, G. A. Snow

Publikováno v: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9781475746013
Biochemistry of Antimicrobial Action ISBN: 9789401068574
Biochemistry of Antimicrobial Action ISBN: 9780412129100
Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9780412821905

Few developments in the history of medicine have had such a profound effect upon human life and society as the development of the power to control infections due to micro-organisms. The impact has been felt in many ways. The developed countries have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902458f4777df398f6bbf28077c762b
https://doi.org/10.1007/978-1-4757-4599-3_1

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Inhibitors of protein biosynthesis

Autor: G. A. Snow, T. J. Franklin

Publikováno v: Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9780412821905
Biochemistry and Molecular Biology of Antimicrobial Drug Action ISBN: 9781475746013

The process of protein synthesis, in which the information encoded by the four-letter alphabet of nucleic acid bases is translated into defined sequences of amino acids linked by peptide bonds, is an exquisitely complex process involving more than 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a518f95efcede7fb72ebff0759c8438e
https://doi.org/10.1007/978-94-010-9127-5_5

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Human colorectal carcinoma cells in vitro as a means to assess the metabolism of analogs of mycophenolic acid

Autor: T J, Franklin, V N, Jacobs, G, Jones, P, Ple

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(3)

Cultures of the human colorectal carcinoma line, HT29, were used to assess the susceptibility to glucuronidation of the cytostatic, immunosuppressive drug mycophenolic acid (MPA) and 19 of its analogs. Removal of the metabolically vulnerable 7-hydrox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d7fa3a168f608a6544357bac6615d4d
https://pubmed.ncbi.nlm.nih.gov/9172956

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