Výsledky vyhledávání - "T J, Deerinck"

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

Autor: Jacob M. Wozniak, Duran González, John C. Guatelli, Andrea Thor, T. J. Deerinck, John D. Lapek, Charlotte A. Stoneham, Lars Pache, P. De Jesus, Sumit K. Chanda, Simon Langer, Mark H. Ellisman

Publikováno v: PLoS pathogens, vol 17, iss 11
PLoS Pathogens, Vol 17, Iss 11, p e1009409 (2021)
PLoS Pathogens

The HIV-1 accessory protein Vpu modulates membrane protein trafficking and degradation to provide evasion of immune surveillance. Targets of Vpu include CD4, HLAs, and BST-2. Several cellular pathways co-opted by Vpu have been identified, but the pic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051e14dc327c720f9172583cb6a5bc56
https://doi.org/10.1371/journal.ppat.1009409

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CDeep3M - Plug-and-Play cloud based deep learning for image segmentation of light, electron and X-ray microscopy

Autor: Daniela Boassa, S. Peltier, Akay R, Sebastien Phan, Eric A. Bushong, Christopher Churas, Lucas Tindall, Matthew Madany, Matthias G. Haberl, Mark H. Ellisman, T. J. Deerinck

As biological imaging datasets increase in size, deep neural networks are considered vital tools for efficient image segmentation. While a number of different network architectures have been developed for segmenting even the most challenging biologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d62b014b9f063a5a0f2549260b17e0

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High-performance serial block-face SEM of nonconductive biological samples enabled by focal gas injection-based charge compensation

Autor: T J, Deerinck, T M, Shone, E A, Bushong, R, Ramachandra, S T, Peltier, M H, Ellisman

Publikováno v: Journal of microscopy. 270(2)

A longstanding limitation of imaging with serial block-face scanning electron microscopy is specimen surface charging. This charging is largely due to the difficulties in making biological specimens and the resins in which they are embedded sufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26640474e34aaf7acb33aa4baa0f3eae
https://pubmed.ncbi.nlm.nih.gov/29194648

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Advances in molecular probe-based labeling tools and their application to multiscale multimodal correlated microscopies

Autor: Eric A. Bushong, T. J. Deerinck, Mark H. Ellisman, Daniela Boassa, Alice Y. Ting, Keunyoung Kim, Sebastien Phan

Publikováno v: Springer Berlin Heidelberg

The need to determine the precise subcellular distribution of specific proteins and macromolecular complexes in cells and tissues has been the major driving force behind the development of new molecular-genetic and chemical-labeling approaches applic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913bb818f2075532e0704f4b34ac7a92
http://hdl.handle.net/1721.1/105352

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Automated microscopy system for mosaic acquisition and processing

Autor: James C. Bouwer, Diana L. Price, Maryann E. Martone, Hiroyuki Hakozaki, Mark H. Ellisman, T. J. Deerinck, Steven T. Peltier, Sunny K. Chow, Natalie A. B. MacLean

Publikováno v: Journal of Microscopy. 222:76-84

An automatic mosaic acquisition and processing system for a multiphoton microscope is described for imaging large expanses of biological specimens at or near the resolution limit of light microscopy. In a mosaic, a larger image is created from a seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585b0517f8f435f286c0eb6dbb79700e
https://doi.org/10.1111/j.1365-2818.2006.01577.x

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Automated most-probable loss tomography of thick selectively stained biological specimens with quantitative measurement of resolution improvement

Autor: Maryann E. Martone, James C. Bouwer, Albert F. Lawrence, Mark H. Ellisman, Mason R. Mackey, Steven T. Peltier, Ying Jones, T. J. Deerinck, Masako Terada

Publikováno v: Journal of Structural Biology. 148:297-306

We describe the technique and application of energy filtering, automated most-probable loss (MPL) tomography to intermediate voltage electron microscopy (IVEM). We show that for thick, selectively stained biological specimens, this method produces a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7531bbaf7b7e5bf47abd4e827bce4070
https://doi.org/10.1016/j.jsb.2004.08.005

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NF-M is an essential target for the myelin-directed 'outside-in' signaling cascade that mediates radial axonal growth

Autor: Yasuo Uchiyama, Darren Young, Mark H. Ellisman, Don W. Cleveland, John Crum, Sameer B. Shah, Michael L. Garcia, Takahiro Gotow, T. J. Deerinck, Nigel A. Calcutt, Thomas O. Crawford, Christopher M. Ward, Christian S. Lobsiger

Publikováno v: The Journal of Cell Biology
The Journal of cell biology, vol 163, iss 5

Neurofilaments are essential for acquisition of normal axonal calibers. Several lines of evidence have suggested that neurofilament-dependent structuring of axoplasm arises through an “outside-in” signaling cascade originating from myelinating ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef604ae836a8cb87d7004d44723ea135
https://doi.org/10.1083/jcb.200308159

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Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways

Autor: Rosa M. Calvo, Shanaka Stanislaus, Hitoshi Osaka, Palmer Taylor, Tony L. Yaksh, T. J. Deerinck, Imran M. Khan

Publikováno v: The Journal of Comparative Neurology. 467:44-59

Neuronal nicotinic receptors (nAChR) are pentameric assemblies of subunits of a gene family where specified combinations of alpha and beta subunits form functional receptors. To extend our understanding of the role of spinal nAChR in the processing o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a4ac005a785ea6de3505bdf1fd04ce
https://doi.org/10.1002/cne.10913

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Overexpression of the CT GalNAc Transferase in Skeletal Muscle Alters Myofiber Growth, Neuromuscular Structure, and Laminin Expression

Autor: Paul T. Martin, T. J. Deerinck, Bing Xia, Anja Kammesheidt, Kwame Hoyte, Mark H. Ellisman

Publikováno v: Developmental Biology. 242:58-73

Carbohydrates have been shown to mediate or modulate a number of important events in the development of the nervous system; however, there is little evidence that they participate directly in the development of synapses. One carbohydrate structure th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3bef25a4df2027803f7a1a8572b1a4f
https://doi.org/10.1006/dbio.2001.0530

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Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

Autor: Hugo B. Sanchez, Jacqueline K. Morris, T. J. Deerinck, Mark H. Ellisman, Kuo-Fen Lee, Weichun Lin

Publikováno v: Proceedings of the National Academy of Sciences. 97:1299-1304

Receptor tyrosine kinase erbB2, which is activated by neuregulin, is expressed in Schwann and muscle cells in the developing neuromuscular junction (NMJ). In vitro studies have shown that neuregulin promotes the survival and migration of Schwann cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca36b6db70c9d822bd2bc3b2a0f21ae
https://doi.org/10.1073/pnas.97.3.1299

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