Zobrazeno 1 - 10 of 64 pro vyhledávání: '"T J, Bardos"'
2
The activation of murine macrophages and natural killer cells by the partially thiolated double stranded RNA poly(I)-mercapto poly(C)
Autor: P F, Cavanaugh, Y K, Ho, T J, Bardos
Publikováno v: Research communications in molecular pathology and pharmacology. 91(2)
Partially thiolated analogs of the biological response modifier poly I.poly C (pI.pC) were synthesized. Each of these analogs (pI.MPC) contained a partially thiolated polycytidylate (MPC) strand containing either 1.2%, 4.6%, or 17% 5-mercaptocytosine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::826adfd20e846fc90f19370d7fa0626d
https://pubmed.ncbi.nlm.nih.gov/8832906
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3
Structure-activity relationships and mode of action of 5-mercapto-substituted oligo- and polynucleotides as antitemplates inhibiting replication of human immunodeficiency virus type 1
Autor: T. J. Bardos, A. R. Heider, Kah-Hiing John Ling, R. F. Schinazi
Introduction of a reactive 5-mercapto group into some of the cytosine and/or uracil bases of various oligo- and polynucleotides by partial thiolation resulted in several potent inhibitors of the replication of human immunodeficiency virus type 1 (HIV
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb35eb62bdf1c3c0a9994c5bae402ae
https://europepmc.org/articles/PMC189236/
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4
Inhibition of human cancer cell lines in vitro with mono- and polynucleotides containing 5-mercaptocytosine bases
Autor: B Q, Geng, Y K, Ho, R G, Hughes, T J, Bardos
Publikováno v: Zhongguo yao li xue bao = Acta pharmacologica Sinica. 12(2)
Partially thiolated polycytidylic acid (5-mercaptopolycytidylic, MPC) and its double-stranded complex with polyinosinic acid [poly (I)].poly(I).MPC, were assayed in both antiproliferative and cytotoxicity tests against human cell lines: lung carcinom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c191e09cbccbfa84fa9616786222326
https://pubmed.ncbi.nlm.nih.gov/1776473
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5
Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate
Autor: T. J. Bardos, T. I. Kalman, Seyuen Choi
Publikováno v: Journal of Medicinal Chemistry. 22:618-621
5-Selenium-substituted derivatives (diselenides) or uracil, 2'-deoxyuridine, and 2'-deoxyuridylic acid were synthesized via the addition of methyl hypobromite to the 5,6 double bond, followed by reaction of the adducts with sodium diselenide. The phy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6abc504f46ee55129069697b978e08
https://doi.org/10.1021/jm00192a004
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6
Pyrimido[5,4-b]quinolines. III. Synthesis of 10-alkyl-substituted 10-deazaalloxazines
Autor: T. J. Bardos, C. K. Chu
Publikováno v: Journal of Heterocyclic Chemistry. 14:1053-1057
A general method for the synthesis of 10-alkyl-substituted 10-deazaalloxazines (VIII) and the related chemistry are described. 4-Alkyl-substituted 3-aminoquinolines (IV) were reacted with benzoyl chloride and potassium cyanide in methylene chloride-w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bfec459dadfed576410e9e3cad21dd0
https://doi.org/10.1002/jhet.5570140621
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8
ChemInform Abstract: SYNTHESIS AND INHIBITION ANALYSIS OF 2(4)-IMINO-4(2)-AMINO-2,4-DIDEOXYRIBOFLAVIN, A DUAL ANTAGONIST OF RIBOFLAVIN AND FOLINIC ACID
Autor: T. J. Bardos, C. K. Chu
Publikováno v: Chemischer Informationsdienst. 8
The synthesis of the 2,4-diamino analogue of riboflavin is described. Inhibition analysis in a microbial assay system indicated that this compound has a weak antifolate activity that could be overcome with a minimal amount of folinic acid, but at hig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::600e2a6669b8f5b45aeaaa7970c468a1
https://doi.org/10.1002/chin.197727237
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10
Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides
Autor: T. J. Bardos, G. A. Lewandowski, Michael H. Fisher, Yung-Chi Cheng, S. M. N. Efange, Ginger E. Dutschman, Susan P. Grill
Publikováno v: Antimicrobial agents and chemotherapy. 33(3)
Several 5-substituted 2-pyrimidinone 2'-deoxyribonucleoside (PdR) analogs were examined for their anti-herpes simplex virus (HSV) activity in cell culture. The order of potency of their antiviral activities against HSV type 1 (HSV-1) and HSV-2 was io
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fe5fc664d0bcf41ccfe431d135525d
https://pubmed.ncbi.nlm.nih.gov/2543279
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