Zobrazeno 1 - 10
of 884
pro vyhledávání: '"T Hennessy"'
Autor:
Neil T Conlon, Sandra Roche, Amira F Mahdi, Alacoque Browne, Laura Breen, Johanna Gaubatz, Justine Meiller, Fiona O'Neill, Lorraine O'Driscoll, Mattia Cremona, Bryan T Hennessy, Lisa D Eli, John Crown, Denis M Collins
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102073- (2024)
Background: HER2-targeted therapies have revolutionised the treatment of HER2-positive breast cancer. However, de novo resistance or the emergence of acquired resistance is a persistent clinical problem. Here we report that neratinib, an irreversible
Externí odkaz:
https://doaj.org/article/80c2e8e9bf2e4172bafb263c57f5769f
Autor:
Gavin P. Dowling, Sinead Toomey, Philip Bredin, Imelda Parker, Eibhlin Mulroe, Jacinta Marron, Olivia McLoughlin, Ausra Teiserskiene, Colm Power, Anne Marie O’Shea, Megan Greally, Patrick G. Morris, Deirdre Duke, Arnold D. K. Hill, Bryan T. Hennessy
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background The current standard of care in the neoadjuvant setting for high-risk HER2-positive (HER2 +) breast cancer is to combine systemic chemotherapy with dual HER2 blockade, trastuzumab and pertuzumab. Targeted therapies have significan
Externí odkaz:
https://doaj.org/article/525da2fab1674ea289c10763a6526868
Autor:
Nicola Cosgrove, Alex J. Eustace, Peter O’Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blümel, Darren O’Connor, Sudipto Das, Małgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to better identify patients with early stage disease who may benefit from tailored treatments i
Externí odkaz:
https://doaj.org/article/2aa94f4a6ce8446ea48464a6049912d0
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 9, Pp 6249-6262 (2023)
ABSTRACT: Grass management technologies (grass measuring devices and grassland management decision support tools) have been identified as important tools to improve the performance of pasture-based dairy farms. They have the potential to significantl
Externí odkaz:
https://doaj.org/article/87c20ee75d1b4bdf9a61ffd4e10b4897
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 4, Pp 2498-2509 (2023)
ABSTRACT: Precision livestock farming (PLF) technologies have been widely promoted as important tools to improve the sustainability of dairy systems due to perceived economic, social, and environmental benefits. However, there is still limited inform
Externí odkaz:
https://doaj.org/article/89d528ad0fcb4ce193f7f8070f16013c
Autor:
Cha Len Lee, Mattia Cremona, Angela Farrelly, Julie A. Workman, Sean Kennedy, Razia Aslam, Aoife Carr, Stephen Madden, Brian O’Neill, Bryan T. Hennessy, Sinead Toomey
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Background Studies have demonstrated the efficacy of Palbociclib (CDK 4/6 inhibitor), Gedatolisib (PI3K/mTOR dual inhibitor) and PD0325901 (MEK1/2 inhibitor) in colorectal cancer (CRC), however single agent therapeutics are often limited by the devel
Externí odkaz:
https://doaj.org/article/d6504dd8615048a28a9b44cb8dd1ecfd
Autor:
Ahmed Rashed, Orla M Fitzpatrick, David J Easty, Zac Coyne, Dearbhaile Collins, Victoria Mallet, Maciej Milewski, Keith Egan, Oscar S Breathnach, Liam Grogan, Bryan T Hennessy, Patrick G Morris
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Purpose Breast cancer is one of the most prevalent malignant diseases in women. The development of dose dense chemotherapy regimens has improved clinical outcomes but has been associated with increased hematological toxicity. Currently there
Externí odkaz:
https://doaj.org/article/4387ad9c450c447893806b3be04b7468
Autor:
Gavin P. Dowling, Stephen Keelan, Sinead Toomey, Gordon R. Daly, Bryan T. Hennessy, Arnold D. K. Hill
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
PurposeThe development of human epidermal growth factor receptor 2 (HER2)-directed therapies has revolutionized the treatment of HER2-positive breast cancer. The aim of this article is to review the continually evolving treatment strategies in the ne
Externí odkaz:
https://doaj.org/article/6a03b95135c141528bd2fbe1e3202046
Publikováno v:
Irish Journal of Agricultural and Food Research, Vol 60, Iss 1, Pp 129-141 (2021)
In line with growing consumer interest in sustainable food production, a number of farm-level sustainability indicator studies have been published in recent years. Despite the importance of animal welfare, many such frameworks fail to adequately take
Externí odkaz:
https://doaj.org/article/9c80541eef9042249b21039af0d6988c
Publikováno v:
Journal of Pathology and Translational Medicine, Vol 55, Iss 6, Pp 415-418 (2021)
Externí odkaz:
https://doaj.org/article/6c3d34f4b47b45eeb2de4b6069c0b8da