Zobrazeno 1 - 10
of 963
pro vyhledávání: '"T Heise"'
Autor:
Xiang Liu, Wern Hann Ng, Eva Zusinaite, Joseph Freitas, Adam Taylor, Venugopal Yerragunta, Shukra Madhaha Aavula, Sambaiah Gorriparthi, Santhakumar Ponsekaran, Rama Lakshmi Bonda, Priyanka Mani, Sridevi V. Nimmagadda, Sainan Wang, Laura Sandra Lello, Ali Zaid, Ujjwal Dua, Sharon A. Taft-Benz, Elizabeth Anderson, Victoria K. Baxter, Sanjay Sarkar, Zheng L. Ling, Thomas M. Ashhurst, Samuel M. S. Cheng, Priyabrata Pattnaik, Anand Kumar Kanakasapapathy, Ralph S. Baric, Felicity J. Burt, Malik Peiris, Mark T. Heise, Nicholas J. C. King, Andres Merits, Rajendra Lingala, Suresh Mahalingam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) continues its significant health and economic impact globally. Despite the success of spike-protein vaccines in preventing severe disease, long-lasting protection against
Externí odkaz:
https://doaj.org/article/1d058aac3c414955a9f8d09ea4a167c5
Autor:
Jacob A. Dillard, Sharon A. Taft-Benz, Audrey C. Knight, Elizabeth J. Anderson, Katia D. Pressey, Breantié Parotti, Sabian A. Martinez, Jennifer L. Diaz, Sanjay Sarkar, Emily A. Madden, Gabriela De la Cruz, Lily E. Adams, Kenneth H. Dinnon, Sarah R. Leist, David R. Martinez, Alexandra Schäfer, John M. Powers, Boyd L. Yount, Izabella N. Castillo, Noah L. Morales, Jane Burdick, Mia Katrina D. Evangelista, Lauren M. Ralph, Nicholas C. Pankow, Colton L. Linnertz, Premkumar Lakshmanane, Stephanie A. Montgomery, Martin T. Ferris, Ralph S. Baric, Victoria K. Baxter, Mark T. Heise
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Whole virus-based inactivated SARS-CoV-2 vaccines adjuvanted with aluminum hydroxide have been critical to the COVID-19 pandemic response. Although these vaccines are protective against homologous coronavirus infection, the emergence of nove
Externí odkaz:
https://doaj.org/article/cb3e0acd8ad14cc99cbe0b46766b9c48
Autor:
Alexandra Schäfer, Lisa E. Gralinski, Sarah R. Leist, Brea K. Hampton, Michael A. Mooney, Kara L. Jensen, Rachel L. Graham, Sudhakar Agnihothram, Sophia Jeng, Steven Chamberlin, Timothy A. Bell, D. Trevor Scobey, Colton L. Linnertz, Laura A. VanBlargan, Larissa B. Thackray, Pablo Hock, Darla R. Miller, Ginger D. Shaw, Michael S. Diamond, Fernando Pardo Manuel de Villena, Shannon K. McWeeney, Mark T. Heise, Vineet D. Menachery, Martin T. Ferris, Ralph S. Baric
Publikováno v:
Virus Research, Vol 344, Iss , Pp 199357- (2024)
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Althou
Externí odkaz:
https://doaj.org/article/b0e04c6b05a3457095b5a1d8a67680f6
Autor:
Conor M. Lewis, Charles T. Heise, Natalia Harasimiuk, Jennifer Tovey, Jian R. Lu, Thomas A. Waigh
Publikováno v:
APL Bioengineering, Vol 8, Iss 2, Pp 026105-026105-8 (2024)
The viscoelasticity of monoclonal antibodies (mAbs) is important during their production, formulation, and drug delivery. High concentration mAbs can provide higher efficacy therapeutics (e.g., during immunotherapy) and improved efficiency during the
Externí odkaz:
https://doaj.org/article/3f9f7e7dde6947139450411208214f3a
Autor:
Laura I. Levi, Emily A. Madden, Jeremy Boussier, Diana Erazo, Wes Sanders, Thomas Vallet, Veronika Bernhauerova, Nathaniel J. Moorman, Mark T. Heise, Marco Vignuzzi
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1794 (2024)
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that poses an emerging threat to humans. In a manner similar to other RNA viruses, CHIKV encodes an error-prone RNA polymerase which, in addition to producing full-length genomes, gives rise to
Externí odkaz:
https://doaj.org/article/00b34d58734a413eb02922eff3e1bfa2
Autor:
Sunil K. Ahuja, Muthu Saravanan Manoharan, Grace C. Lee, Lyle R. McKinnon, Justin A. Meunier, Maristella Steri, Nathan Harper, Edoardo Fiorillo, Alisha M. Smith, Marcos I. Restrepo, Anne P. Branum, Matthew J. Bottomley, Valeria Orrù, Fabio Jimenez, Andrew Carrillo, Lavanya Pandranki, Caitlyn A. Winter, Lauryn A. Winter, Alvaro A. Gaitan, Alvaro G. Moreira, Elizabeth A. Walter, Guido Silvestri, Christopher L. King, Yong-Tang Zheng, Hong-Yi Zheng, Joshua Kimani, T. Blake Ball, Francis A. Plummer, Keith R. Fowke, Paul N. Harden, Kathryn J. Wood, Martin T. Ferris, Jennifer M. Lund, Mark T. Heise, Nigel Garrett, Kristen R. Canady, Salim S. Abdool Karim, Susan J. Little, Sara Gianella, Davey M. Smith, Scott Letendre, Douglas D. Richman, Francesco Cucca, Hanh Trinh, Sandra Sanchez-Reilly, Joan M. Hecht, Jose A. Cadena Zuluaga, Antonio Anzueto, Jacqueline A. Pugh, South Texas Veterans Health Care System COVID-19 team, Brian K. Agan, Robert Root-Bernstein, Robert A. Clark, Jason F. Okulicz, Weijing He
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-31 (2023)
Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as the capacity to preserve and/
Externí odkaz:
https://doaj.org/article/2d05c47c46834fc38503fbfb37c7eb1f
Autor:
Stephanie E. Ander, Kathryn S. Carpentier, Wes Sanders, Cormac J. Lucas, Austin J. Jolly, Cydney N. Johnson, David W. Hawman, Mark T. Heise, Nathaniel J. Moorman, Thomas E. Morrison
Publikováno v:
Viruses, Vol 16, Iss 6, p 861 (2024)
We previously reported that deletion of a 44-nucleotide element in the 3′ untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here, we find that while this 44-nucleotide deletion enha
Externí odkaz:
https://doaj.org/article/de9d1c236b594b4e9eb72f3e4301308c
Autor:
Jennifer Diaz, John Sears, Che-Kang Chang, Jane Burdick, Isabella Law, Wes Sanders, Colton Linnertz, Paul Sylvester, Nathaniel Moorman, Martin T. Ferris, Mark T. Heise
Publikováno v:
Viruses, Vol 16, Iss 4, p 636 (2024)
RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand the evolutionary fitness of novel viral variants re
Externí odkaz:
https://doaj.org/article/afcc2e359b2944a89cbb7635dfd9a8a0
Autor:
Marta C. Cruz Cisneros, Elizabeth J. Anderson, Brea K. Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A. Bell, Matthew Blanchard, Jacob A. Dillard, Kenneth H. Dinnon, Pablo Hock, Sarah R. Leist, Emily A. Madden, Ginger D. Shaw, Ande West, Ralph S. Baric, Victoria K. Baxter, Fernando Pardo-Manuel de Villena, Mark T. Heise, Martin T. Ferris
Publikováno v:
Vaccines, Vol 12, Iss 1, p 103 (2024)
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants, host age,
Externí odkaz:
https://doaj.org/article/43d9495ddc00404dbe9f7ec34a4f0cf8
Autor:
Lily E. Adams, Sarah R. Leist, Kenneth H. Dinnon, III, Ande West, Kendra L. Gully, Elizabeth J. Anderson, Jennifer F. Loome, Emily A. Madden, John M. Powers, Alexandra Schäfer, Sanjay Sarkar, Izabella N. Castillo, Jenny S. Maron, Ryan P. McNamara, Harry L. Bertera, Mark R. Zweigert, Jaclyn S. Higgins, Brea K. Hampton, Lakshmanane Premkumar, Galit Alter, Stephanie A. Montgomery, Victoria K. Baxter, Mark T. Heise, Ralph S. Baric
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112326- (2023)
Summary: Group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective immunity, currently less clear yet important for pan-sarbecovirus vacci
Externí odkaz:
https://doaj.org/article/7da7f2fa9eee4314bfa59cc3b0f22f10